213. Rose Ferguson: Q&A on MTHFR Gene Mutation, Autoimmune Disease, Cognitive Decline, & More!

28 Oct 2025 · 1 h 5 min · 25 chapters

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In short

Live Q&A on nutrition for longevity and health, covering protein targets, rosacea, gut health/leaky gut, autoimmune disease, vegan/gluten concerns, ADHD and methylation, MTHFR gene mutation, hair loss/alopecia, exercise fueling, and preventing cognitive decline/Alzheimer’s.

Guests

Rose Ferguson is a nutritionist and functional medicine clinician with a master’s in advanced nutrition and research/practice; she founded “Our Health Club” and the “Five Day Plan.” Gary Brecka is a human biologist/researcher and biohacker; he previously worked as a mortality expert for 22 years.

Key claims

Supplement for deficiencies, not “for the sake of supplementing.” Protein can be supplemented with essential amino acids (Perfect Amino) to meet ~150g/day without caloric impact. Rosacea is driven by low-grade inflammation and gut/microbiome issues; supports include hydration, hydrogen water, minerals, and microbiome work. Autoimmune disease is largely gut-leaky-gut related (Rose cites leaky gut as a first domino; Gary emphasizes immune dysfunction from gut disruption). MTHFR mutation impairs methylation of folic acid; methylfolate/folinic acid can “neutralize” it. Avoid fortified/enriched foods; gluten issues are framed as processing/fortification rather than gluten protein itself. Cognitive decline is framed as “type 3 diabetes” (brain insulin resistance); control glycemic profile and insulin.

Notable examples

Lucky Charms vs grass-fed steak pyramid; peanuts/peanut butter linked to mold/mycotoxins and lectins; Russia allegedly restricts GMO crops; alopecia linked to maternal inheritance and DHT; exosomes/red light therapy suggested; endurance athletes need carbs, while most people should balance intake/utilization.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Audience Interaction Begins

0:45 to 1:10

Rose Ferguson engages with the audience and opens the floor for questions.

“In terms of supplementation, you know, I'm not a big fan of supplementing for the sake of supplementing.”

Rose's Background and Approach to Nutrition

1:10 to 1:52

Rose shares her background, experience, and approach to nutrition and health.

“Welcome back to the Ultimate Human podcast.”

First Audience Question: Nutrition for Teens

1:52 to 2:55

Discussion about how to manage a teenager's nutrition when control is limited.

“And then my favorite thing is we'll open it up for questions.”

Nutritional Advice for Children and Processed Foods

2:55 to 6:03

Rose discusses the impact of processed foods and offers practical nutritional advice for children.

“I'd love to open it up for some questions about nutrition.”

Protein Intake and Supplementation Strategies

6:03 to 9:07

Advice on meeting protein requirements and the use of supplements like Perfect Amino.

“I'd be really looking after keeping it positive, I suppose.”

Understanding Food Types: Peanuts and Mycotoxins

9:07 to 11:22

Discussion about the risks associated with peanuts and their classification as legumes.

“you're intermittent fasting, you can supplement with perfect aminos outside of that fasted window because it doesn't break a fast.”

Gut Health and Autoimmune Diseases

11:22 to 13:50

Exploration of gut health's influence on autoimmune diseases and overall wellness.

“But, you know, peanuts are just one of those things.”

The Connection Between Gut and Overall Health

13:50 to 14:00

Final thoughts on the importance of gut health and its connections to other health conditions.

“that really, if you never have, you should start, you know, do a bit of work on your gut.”

Understanding Autoimmune Diseases and Gut Health

14:00 to 16:28

Learn about the connection between gut health and autoimmune diseases, including potential origins and impacts.

“But But, you know, what's fascinating is years ago I read a book by Dr.”

Nutrition's Role in Skin Conditions

16:31 to 19:24

Explore how nutrition might reverse skin issues like rosacea and its relation to gut bacteria.

“So my question, I spoke to Rose yesterday about this, But I'd love to know your take on nutrition and how it could perhaps reverse issues like rosacea.”
Show all 25 chapters

The Importance of Vascular Health

19:24 to 23:15

Discuss the significance of vasomotor circulation and its effects on skin conditions.

“Cardiac is only in the cardiac muscle, it's only in the heart.”

Challenges of a Plant-Based Diet

23:15 to 24:48

Understand the potential pitfalls and preparations needed for a healthy plant-based diet.

“And veganism, vegetarianism, I don't have any problem with either one.”

Gluten Sensitivity and ADHD

24:48 to 28:00

Examine the rising gluten sensitivities and their implications on ADHD and nutrition.

“I've been seeing quite a lot of research around gluten in general and how regardless of whether you have an intolerance or not, it's bad for you and bad for your digestion.”

Understanding Gluten Sensitivity

28:00 to 30:29

Explore the complexities of gluten sensitivity and its effects on health.

“And so the actual disease of not being able to process gluten is rare, but the sensitivity of gluten is profound.”

MTHFR Gene Mutation Explained

30:30 to 34:25

Learn about the MTHFR gene mutation and its implications for health.

“They feel they don't have digestive issues so much.”

Nutritional Insights and Hair Loss

35:26 to 42:00

Discuss the impact of nutrition on hair loss and treatment options.

“So we created a synthetic form of B12 called cyanocobalamin, which by the way, is also a nutrient you should never put in your body.”

Balancing Longevity and Performance

42:00 to 44:27

Discover the trade-offs between short-term performance gains and long-term health implications.

“They take exogenous anabolic steroids, and they perform incredibly well.”

Nutrition for Endurance Athletes

44:27 to 46:29

Learn about the nutritional needs of endurance athletes and the importance of carbohydrate balance.

“It's more about how do you get the correct amount of carbohydrates to perform at a high level in endurance sports, but also do it in a way that's healthy?”

Understanding Alzheimer's and Cognitive Decline

46:29 to 50:21

Explore genetic predispositions to cognitive decline and how diet can influence brain health.

“Okay, we've got a couple more minutes left.”

The Impact of Insulin on Brain Health

51:34 to 54:38

Understand the relationship between insulin sensitivity and cognitive function, especially in Alzheimer's.

“Now let's get back to the Ultimate Human podcast.”

The Controversy of Statins and Cognitive Health

54:38 to 56:00

Delve into the debate over statin use and its potential links to cognitive decline.

“leading causes of the parabolic rise in Alzheimer's.”

Understanding Thyroid Autoimmunity

56:00 to 58:01

Learn about the potential causes of autoimmune responses in the thyroid.

“And she has done a recent blood test and her TPO and trap are high.”

Exploring the Ketogenic Diet

58:02 to 1:01:02

Discover the benefits and challenges of maintaining a ketogenic diet.

“That being said, it doesn't mean that we shouldn't eat carbohydrates.”

Managing Keto Flu and Sodium Intake

1:01:03 to 1:04:19

Find out how to alleviate the keto flu by managing sodium levels.

“but they're really, really important for the gut and for our microbes.”

Detox Protocols for Heavy Metals

1:04:20 to 1:05:19

Learn about effective protocols for heavy metal detoxification.

“So one more question, then we'll wrap up.”
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Transcript

Automatic transcript. May contain errors.

0:00Gary Brecka:Welcome to the nutritional Q &A. I'd love for you to introduce yourself, I'll introduce myself. My name is Rose Ferguson, I am a nutritionist and a functional medicine practitioner, but at heart I'm a clinician. My absolute favourite thing to do is interact with the audience. I'd love to open it up for some questions. You need to get 150 grams of protein, which I have trouble with. Is it alright to supplement that with protein shakes? If you are going to use protein powder, make sure it's a really good one. I'd love to know your take on nutrition and how it reverses issues like rosacea. You find the driver, what's driving it.

0:33Is it stress?

0:34Gary Brecka:Is it gut health? Hydrogen water, proper hydration, 91 essential minerals, and having good microbiome. My son is at boarding school. I don't have as much control over his nutrition as I'd like to. What are the things you would suggest? In terms of supplementation, you know, I'm not a big fan of supplementing for the sake of supplementing. I'm a huge fan of supplementing for deficiency. I also think a multi-mineral is really useful because if they are dodging the veg...

1:10Gary Brecka:Welcome back to the Ultimate Human podcast. This one is special recorded live from the health experience in London, UK with nutrition expert Rose Ferguson. We sat down for an incredible live Q &A session with the audience to talk about the truth behind modern diets, nutrition myths, and what it actually means to eat for health and longevity. Rose brings a wealth of experience from working with everyone from everyday people to elite performers, and she has a refreshingly simple approach to food that cuts through all the noise. If you've ever felt overwhelmed by what you eat or how to start, this conversation will help you find clarity and confidence in your nutrition journey.

1:47Gary Brecka:Let's get into it with the amazing Rose Ferguson. Wow, I almost feel like I just should just stay in the seat. I see a lot of familiar faces. Guys, welcome to the nutritional Q &A. I'd love for you to introduce yourself. I'll introduce myself. And then my favorite thing is we'll open it up for questions. Okay. Hi, everyone. My name is Rose Ferguson. I am a nutritionist and a functional medicine practitioner. I have a master's in advanced nutrition and research and practice. I'm the founder of our health club and the five day plan, but at heart, I'm a clinician. That's what I do. It's the cornerstone of my work.

2:29I've been in this for a long time, so I've seen lots of changes and it's a real pleasure to be here.

2:36Gary Brecka:Yeah. Thank you so much. My name is Gary Brecka. I'm a human biologist, a researcher, a biohacker. I was a mortality expert for 22 years, which is a very, very dark part of my career. I see a lot of familiar faces, and my absolute favorite thing to do is to interact with the audience. So why don't we open? It's a nutritional Q &A. I'd love to open it up for some questions about nutrition. Yes, ma 'am, in the back. Do we have a microphone? Or you can just scream, and I'll repeat it. Hi, I've got a son. Hi, my son is at boarding school. He's a teenager, and I don't have as much control over his nutrition as I'd like to.

3:16Gary Brecka:So what are the top five things you would suggest I should be giving him to supplement with? So in terms of supplementation, I'm not a big fan of supplementing for the sake of supplementing. I'm a huge fan of supplementing for deficiency. You can do a genetic methylation test on him, and that will tell you exactly what his body is deficient in. what his body can and cannot methylate, what his body can and cannot break down. And then you can use what's called a methylated multivitamin. I'd really suggest you use mine, but you don't have to. But that is a game changer. And in terms of just basic nutrition, obviously, the secret to longevity, and I absolutely want to hear your opinion on this, is eating whole foods.

4:06Gary Brecka:so teaching them the difference between what is a highly processed food and what is a whole food what's really interesting about processed foods especially in young children prepubescent teens and young children is eating highly processed foods not only changes your palate it changes your desires um it you know processed foods are meant to drive the addiction to processed foods I mean, they are designed to be addictive. In the United States, 74 % of our nutritional research is funded by big food and big pharma. We're in the process of getting that corruption out of our nutritional research. I chair Bobby Kennedy's Maha Action Committee, and our big focus is to actually stop that.

4:49Gary Brecka:But this is why we have a food pyramid that says that Lucky Charms is more nutritious than grass-fed steak. Does anybody believe that Lucky Charms is more nutritious than grass-fed steak? um well that's oh you do good one honest person back there just i just had a bowl of lucky charms on the way here um but go ahead yeah i was gonna say it's really difficult um i think also the other thing that i would say around children is relationship with food you know if you're looking at the long-term health of a child's relationship and the way that they eat their relationship with food which is absolutely skewed by upfs it's also making them comfortable to feed because i see so much restriction going on.

5:29So that's what I'll be thinking long term. I also think a multi-mineral is really useful because if they are dodging the veg in the canteen, then their mineral, I mean, vegetables are already reduced to mineral content. So I would definitely, I would think about that perhaps. And I would do, I wouldn't stress, I wouldn't for you, I wouldn't be stressing about it. They'll be fine. They're really resilient. And I would hope that the school are feeding them, I hope that they're taking time to feed them the best that they possibly can. And then when you have your child back, then you can do what you can do.

6:02But I wouldn't stress that you only have so much control, and I wouldn't make it. I'd be really looking after keeping it positive, I suppose.

6:12Gary Brecka:Canteen is such an English word. Canteen. You know, when you say canteen, you just imagine fish and chips. I've drank from a canteen. and just for the record in the states a canteen is a little tin thing that you keep watering canteen in this country it just sums up ideas of plastic trays going along along with sort of gray peas some cold soggy chips fries we would call that a cafeteria yeah well exactly cafeteria to everyone who's not British sure are there any other questions yes sir With my age and the amount of training that I do... You look really fit, by the way. Thank you very much. If you guys can't see him, he's very fit.

6:58I've looked in, researched in that I need to get 150 grams of protein per day, which I have trouble with. Yes. So I'm wondering, is it all right to supplement that with protein shakes? And if so, how much would you suggest?

7:17Gary Brecka:I mean, not to sound entirely self-serving, but I would supplement that protein equivalent with Perfect Amino. So, for example, you can take a scoop of Perfect Amino or five Perfect Amino tablets. It is the equivalent of 29 grams of whey protein. So you'd have to consume 29 grams of whey protein to get a single serving of the amino acid equivalent you would get in a single serving of Perfect Amino. This won't break a fast, so it won't add to your caloric intake. and it's 99 % bioavailable. And you're highlighting a problem that a lot of people have. I spoke about this in my last talk, especially women.

7:52Gary Brecka:Women have a very difficult time meeting their protein equivalent without going over their macros, the total amount of calories that they should consume in a day. Also, a lot of women have a hard time just eating that bulk of protein. So if I were you, I would take your protein deficiency, equate that to 29 grams of whey, and use that as a measure of how many servings of Perfect Amino you should take every single day. It will be a game changer for you. I believe that if you're exercising in a fasted state, that you have to take something like a Perfect Amino before you exercise. Again, it won't add to your chloroquine, will not break your fast, but it will give you the amino acids that you need to keep from metabolizing lean muscle tissue.

8:34It doesn't matter how many times you

8:39Gary Brecka:It doesn't matter how many times you take it during the day. You can take two or three servings in a day. It would be the equivalent of close to 90 grams of whey protein. So if you took three servings in a day, even though you're getting no caloric impact, it would be the equivalent of taking in almost 90 grams of whey protein. So if you're trying to avoid the bulk or you're eating in a narrow feeding window or you have a difficult time meeting your protein equivalent, it's an excellent way to augment that. because even if you're eating in a narrow feeding window, you're intermittent fasting, you can supplement with perfect aminos outside of that fasted window because it doesn't break a fast.

9:13Gary Brecka:Most of the time we define breaking or not breaking a fast as whether or not the liver is involved in metabolizing compounds. So as soon as the liver is engaged, your fast is broken. And the reason why the liver's not engaged is because you're using all nine of the essential amino acids. If you don't have the essential amino acids, your liver can't make them. We can make all of the rest of the amino acids, the 22. The liver can actually take one amino acid and it can actually reformulate it into the non-essential amino acids. So your protein equivalent is really driving your need for essential amino acids, the ones that you need to get by food or supplementation.

9:52Of course.

9:53Gary Brecka:Did you want to also answer that? Well, no. I mean, I think people are always surprised that I think protein shakes or protein powders or essential aminos are a really good thing to include. Most people are too busy. You know, let's be realistic. Who actually sits down and has eggs every morning, has time to make a steak at lunch, and then do some chicken for dinner? I don't have time to do that. And I think if you are going to use protein powder of any sort, make sure it's a really good one. But I do also think when it comes to protein, so I think getting a variety of proteins. So using plant proteins, while they're not as bioavailable, they also come with fiber, and fiber is also really key.

10:29So just adding things in wherever you can, whether it's a few nuts here or, you know, you can just keep adding in. And that does nudge the numbers up. But as Gary said, if you're looking at your caloric intake, then that might nudge you over. But I would also argue that calorie intake, when it comes to nuts, a lot of it is not digestible. So, you know, people who get stressed looking at the caloric number on, you know, of nuts, the benefits from the fat and the protein and the fiber are absolutely outweigh the calorie count you know it's not like eating a snickers it's just not that it's snickers do you have peanuts the old

11:11Gary Brecka:peanut butter peanuts are not nuts no peanuts are legumes they're seeds um it's it's it's sad that they're called peanuts because it sounds like they should be a nut um but they're not they're actually a legume they're seeds um peanuts also are one of the highest foods in mold and mycotoxins um so you know if you can i would actually just cut peanuts and peanut butter out of the diet nut butters are a much better way to go um you know if you've ever actually cracked open a peanut shell um you know and taken the peanuts out and you feel that nice soft velvety surface on the inside okay that's a mycotoxin um and so you know um ochrotoxin a aflatoxin a aflatoxin b some some of the most aggressive mycotoxins that get into the human body enter through peanuts um you know we eat a lot of nuts in in my house and i made the mistake of actually storing them in these big tall glass containers i would buy them in bulk and um and you know it take days or sometimes even weeks to eat my way down to the bottom of those um and i did a test called a vibrant wellness test which is a urine test for mold mycotoxins and other things and i was shocked at how diligent i am with my diet um that nearly the whole family had this very specific type of um ochratoxin ochratoxin a and aflatoxin and um i traced it to the to the peanuts this or to the stored nuts um and uh so now i buy them still in bulk but just not such a volume at a time um and i dry store them and it's fine.

12:42Gary Brecka:But, you know, peanuts are just one of those things. They're legumes, they're seeds. They have very, very high lectins, which some people don't do very well with. They can destroy your gut. Lectins are things that actually have, they're almost like bacteria with little spines on them. And they cause microfissures in the gut. Remember, there's only a single cell layer protecting your inside environment from your outside environment. One cell. One cell layer on the inside lining of your gut it's very easy to disrupt that single cell layer and develop something called leaky gut um and peanuts are a large cause of that i mean i have so much leaky gut in my clinic i'd say that you know because it is it's unbelievable it's this single cell and you know you think how fragile that is and it's like alcohol stress low sleep uh antibiotics um and then also yeah like mycotoxins they all disrupt and then the symptoms i think most people if you haven't done any work on your gut by the time you get into your 30s, 40s, you probably will be suffering with some sort of IBS, digestive symptoms, aching joints, fatigue, headache, skin issues.

13:47Autoimmune. Autoimmune, exactly. So, you know, I think it's something that really, if you never have, you should start, you know, do a bit of work on your gut. Give your gut some love.

13:56Gary Brecka:Oh my gosh. I mean, we can go all down the gut microbiome and the gut pathway. But But, you know, what's fascinating is years ago I read a book by Dr. Perlmutter. It was called Grain Brain. He wrote another one called Gut-Brain Connection. And it really, really opened my eyes to the science between the connectivity between the gut and the brain, the gut and the skin, the gut and autoimmune conditions. I talked extensively about this in another one of my lectures. But, you know, 85 % of all autoimmune disease, all, the entire category of autoimmune, whether it's multiple sclerosis, rheumatoid arthritis, Hashimoto's, chagrins, all of these autoimmune diseases that we believe are life sentences, right?

14:38Gary Brecka:Once you have the autoimmune, you have to subscribe to a lifetime of medication because there's nothing you can do about it. 85 % of these are idiopathic. They are of unknown origin. and I don't believe that anything is idiopathic in the human body. We may not know the origin, but they're not idiopathic. And the vast majority of these, if you trace back to the first domino that fell, it had a gut-related issue, mainly related to leaky gut. You know, the things that are inside of the intestinal tract, inside the luminal area of your intestine, are external to your body. They're meant to be outside of the body.

15:17Gary Brecka:Yes, that tract runs through your body, but it's meant to keep things external from your internal environment. And so when that gets disrupted and it leaks, 70 % of our immune system is sitting right here. Why is 70 % of our immune system surrounding our gut? Because that's where all the action is. And when your immune system is in a low-grade fight for a prolonged period of time, it perverts. It perverts its function. it loses focus and it leads to the genesis of so many autoimmune diseases so it's hard to even describe yes ma 'am if you want protein to build lean muscle but without the caloric impact or need to cut you need perfect amino it's pure essential amino acids the building blocks of proteins in a precise form and ratio that allows for near 100 utilization in building lean muscle and no caloric impact.

16:13Gary Brecka:So we build protein six times as much as whey, but without the excess body fat we normally get during bulking. This is the new era of protein supplementation, and it's real. If you want to build lean muscle without having to cut, you need Perfect Amino. Now let's get back to the Ultimate Human podcast. Thank you so much. So my question, I spoke to Rose yesterday about this, But I'd love to know your take on nutrition and how it could perhaps reverse issues like rosacea. Great question. Do you want to take it first? Well, we spoke about it yesterday. I was talking about low-grade inflammation and just that, you know, and I said to you, find the driver.

16:54What's driving it? Is it stress? Is it gut health? So, yeah, I think we talked about it yesterday. You want Gary's idea, don't you?

17:02Gary Brecka:I think rosacea, like so many other skin conditions, eczema, psoriasis, it's interesting when you start to look at the research on a lot of these conditions, you find very specific strains of gut bacteria are absent. So, for example, in more than 80 % of the autistic population, there are two specific strains of gut bacteria that are absent in their gut. It's not 100 % of the time, but it's very, very consistent. Very high correlation between gut bacteria and autism, the actual makeup of the flora. And this is also true in eczema and psoriasis because the skin is not just a barrier. It's also a gateway.

17:46Gary Brecka:You know, a really good rule of thumb is don't put it on your skin if you wouldn't eat it. It's hard to stick to that rule, but it's a good way for us to think about the kinds of things that we're applying to our skin. Rosacea in particular, which is microvascular circulation, a subdermal layer of the skin, it has to do with something called vasomotor circulation. It has to do with the venules and the capillary. It's usually related to a lack of drainage, which means that it's not draining because it's inflamed. if you think that the vast majority of the vasculature in the human body is as small or smaller than a human hair we've talked about this too 70 of your circulation is not done by your heart the the the entirety of the circulation from the subdermal layer of your skin to the dermal layers that go all the way up and feed the the the dermal layer of the skin which is right below the seven layers of of dead skin none of that has any pressure in it so it is actually not done by our heart.

18:44Gary Brecka:It's done by this activity called vasomotor. So things like hydrogen water, proper hydration, all 91 of the essential minerals, and having a really, really good microbiome are excellent ways to address rosacea. And for that matter, eczema and psoriasis. These are internal issues manifesting in the skin. Do you think hot and cold contrast therapy would be good for that? I think hot and cold contrast therapy is amazing, right? Because hot and cold contrast therapy, you know, vasodilates and vasoconstricts. You know, we don't think about exercising our vascular system, but the vast majority of our vascular system is muscular.

19:21Gary Brecka:So there's three types of muscle in the body, right? We have smooth muscle, we have skeletal muscle, we have cardiac muscle. Cardiac is only in the cardiac muscle, it's only in the heart. But smooth muscle is what lines 63 ,000 miles of blood vessel in your body. and this is a three-layered tier of muscles that are crisscrossed over each other they vasodilate and they vasoconstrict if they couldn't vasodilate or vasoconstrict you couldn't move blood around 70 of your body i always liken this to a snake swallowing a mouse and so anything that helps vasomotor circulation is going to be really really good for your skin including including rosacea so what are the things that help vasomotor circulation red light therapy contrast therapy hot and cold therapy, hydrogen gas, minerals, hydration.

20:07Gary Brecka:You know, so many of us are so chronically dehydrated that we have actually lost the sensation of thirst. So the body has a really interesting way sometimes of signaling when it's in trouble. And one of the ways that it signals that it's in trouble is it stops signaling, right? So if you've ever known somebody who's about to have a heat stroke, they actually get cold to the touch and they stop sweating. If you've actually ever gone to a restaurant and you've gotten to the restaurant and you're voraciously hungry when you get there. So you order everything on the menu. And by the time the food comes out, you're not even hungry anymore.

20:40Gary Brecka:Like, how did that happen? Because when your blood sugar is falling, you get very hungry. Once your blood sugar has fallen, you are no longer hungry. So the body has ways of protecting yourself. When we used to forage for food, if you couldn't find food, it would shut off the sensation for hunger. The same thing happens in chronic dehydration. You know, if you can go an entire day without your body reminding you to drink. That is a sign of chronic dehydration. I know so many people that can go a whole day. She's pointing at her girlfriend. She's like, right here. There is so many people. I was just telling her.

21:11They don't drink at all. And they're like, and do you know why lots of them stop drinking? It's because they don't want to go to the loo.

21:18Gary Brecka:The loo? The loo, the toilet, the restroom. Is the loo near the canteen or is it like on the opposite side of the canteen? I'm giving you like the whole, like this is the English colloquialism. The bathroom. Yeah, the bathroom. The bathroom. By the way, when you guys do business deals here, it's called a scheme. We put people in prison for schemes in the United States. So I'm just getting used to the whole English way of talking. New canteen scheme. I would take that as a scheme. Yes, ma 'am. Thank you. Hi. For people on a vegan diet, there's the obvious ones that are things to think about that people always talk about.

21:56Gary Brecka:Is there anything that both of you have that you would love to kind of put out there as things that we could be thinking about? Absolutely. I think if you are doing plant-based, also in my experience, I've very rarely seen someone doing it well. If you're going to be plant-based, you need to know what you're doing. And it is all about preparation. Because if you, yeah, just to maintain those levels, it's particularly protein is particularly tricky. Sourcing it, when we're talking about the provenance of where you're getting your nuts from, your legumes. your soy, you know, what are you eating to get that protein in?

22:30So I would just be really well read in how to do plant-based diet properly. And the other thing, I would be really, really, really still well clear if there's any of those processed plant foods with a green thing that look healthy. They are, I honestly feel like they're evil because they say they're really healthy and they are really, at least when you buy Haribos, you know you're buying sweets or candy. See, I'm getting there. Yeah. But when you buy the plant-based world of processed ready meals is evil. You know, I honestly think that because it is pretending to be healthy. And see, I start ranting about it.

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23:08But I think if you're going to be vegan, you really need to be very well prepared.

23:13Gary Brecka:I would agree with that. I think that the notion that just because it's not meat that it's healthy is a really misconceived notion. And veganism, vegetarianism, I don't have any problem with either one. one of those. But if you're vegan, it's super important to include things like shelled hemp seeds, for example. It's one of the highest protein concentration vegan foods that you can eat. 10 grams of protein for every single gram of carbohydrate, really high on omega-3 fatty acids, or the right ratio of omega-3 to omega-6 fatty acids, which is also difficult for vegans. And also, when you talk about veganism, beer is vegan.

23:48Gary Brecka:So is wheat, hops, barley, rye vegan? So a lot of the most highly modified, genetically modified crops in the world and the most highly sprayed crops in the world, glyphosate, paraquat, insecticides, are sprayed on, I would say, vegan-friendly foods. So just to be cautious about the amount of grains, cereals, wheat, hops, barley, rye, flour that you eat that is processed. if I was a vegan and I would never be vegan but if I was I would be really really cautious about my source of grains I would make sure that the grains are non-fortified non-enriched and that they're also non GMO you know we we modified these crops to make them resistant to glyphosate all right we didn't modify them to increase their nutritional density or to increase the yield of crops we modified them so that the poison wouldn't kill the plant and when we modified these plants we genetically modified them in a way that makes them very very difficult to digest so to pull nutrients out of genetically modified crops is sometimes very very difficult and so there it's a very highly genetically modified and highly processed area of food production so that would that would be another you know caution of mine and actually it's true because people who are plant-based solely are very carbohydrate very carbohydrate heavy and i'm not anti-carbs at all but if you're having like pasta every night which is the classic isn't it i have what do you eat yeah they're having pasta and this is what i mean you have to really make sure you're getting the variety and not relying on grains because as gary just said they are heavily processed they are not as nutritionally dense as they should be um so it's all about sourcing yes ma 'am Thank you.

25:42Gary Brecka:I've been seeing quite a lot of research around gluten in general and how regardless of whether you have an intolerance or not, it's bad for you and bad for your digestion. So I just wanted to hear your thoughts on that. And I'll just do a two-in-one. Also, any thoughts about people with ADHD, kind of nutrition and the impact that can have? Oh, you just hit a sweet spot for me right there. You want to take that first with the gluten? You go for it.

26:12Gary Brecka:So, you know, first on the gluten thing, you know, what's really interesting about gluten is gluten's been around for centuries. Gluten allergies are relatively recent. You know, gluten sensitivity, gluten allergies are relatively recent. The incidence of celiac disease has skyrocketed parabolically. And you have to ask yourself, do we suddenly become allergic to a protein? Gluten's a protein. Do we suddenly become allergic to a certain protein in our diet just out of nowhere? Did just this mass of population become allergic to gluten? And I think the answer is no. I think what we've become allergic to are what is in gluten-laden foods.

26:49Gary Brecka:And so very often gluten-laden foods are treated and sprayed with folic acid. They're fortified or enriched. Fortified or enriched foods are foods that are actually sprayed with a chemical folic acid. You hear me talk about this all the time. folic acid is not a natural nutrient. It does not occur naturally in nature. You cannot find folic acid anywhere in nature or anywhere on the surface of the earth. We make it in a laboratory. And then we spray it on our food supply and we call that enriched or fortified. With attention deficit disorder especially, enriched and fortified foods can be like cocaine for a six-year-old.

27:26Gary Brecka:It will make their mind race, right? Because the vast majority, not the vast majority, about 46 % of the population can't process folic acid at all. Folic acid is in nearly all gluten-based foods. So the curiosity to me is, are we having a parabolic rise in gluten allergies? Or actually, are we having a parabolic rise in gluten-containing foods that are highly processed? And my impetus would be the latter. And the reason why I say that is true gluten allergies, true celiac allergies are relatively rare. Gluten allergies are massive. And so the actual disease of not being able to process gluten is rare, but the sensitivity of gluten is profound.

28:11Gary Brecka:And so the idea that we just became sensitive to this protein, which has been around for centuries, all of a sudden in modern day society, the big data would say it's something that modern day society is doing to the food that the gluten's not. And so this has to do with how it's processed. So I would avoid fortified or enriched foods. With regard to attention deficit disorder, I'm just going to plug my gene test. You should do a genetic methylation test. Or whoever's suffering from ADHD should do a genetic methylation test. Because this is not an attention deficit disorder. It's an attention overload disorder.

28:46Gary Brecka:It has too many windows open at the same time. It's an inability to successively break down thought at the same pace that we create thought. which creates a very clouded mind um yeah i mean on the gluten front as well because of the way it's even farmed like you know dwarf wheat it can it has it's not the same gluten that we were eating and also the the nutrients in those grains it's like it doesn't even have the nutritional value that it used to have and on top of that when i see people and they say yeah but i feel better because i've cut out gluten i'm like yeah but what have you actually cut out you've cut out cake sausages crappy bread crackers you know burgers crackers the food stuffs that you've cut out are also not particularly positive and so when you cut out the gluten you remove that food those sort of foods from your your world you're going to feel better um but i do think i definitely think the gluten just because of the grains we're eating now that as you say so processed that's what causes the issue not so much the gluten which is why some people who absolutely swear that they cannot eat gluten, well, you'll see them having a bit of sourdough with butter and they're okay because the way that sourdough is fermented so the bacteria do a bit of the work for you before it gets cooked.

30:04And so, yeah. And the other thing is that actually, in theory, everybody should be able to tolerate gluten. It's a protein. We should be able to break it down. So if it's something that's come, is new, what's changed and do you need to come, going back to things like leaky gut, do you need to do a bit of work on your gut? and then try reintroducing it. But, I mean, to be honest, I don't cut it out. I don't like cutting food groups out, but it is a good one to remove. And people suddenly feel clear-headed. They feel they don't have digestive issues so much. So it's worth experimenting on your, you know, you can remove it and see how you feel.

30:38Gary Brecka:It's interesting if you look at broad epidemiological studies, like countries like Russia, where it's an actual felony to grow genetically modified foods. So if you grow genetically modified crops in Russia, you'll go to prison. in the United States we genetically genetically modified the vast majority of our crops again so they can be resistant to glyphosate paraquat and other insecticide and pesticides and so you know I think a lot of this has to do with the chemical laden nature of these foods and not necessarily with the protein itself you know so it's like we we spend a lot of time blaming the butter for what the bread did.

31:14Yeah.

31:16Gary Brecka:Did you have a question right here in the middle? Yes, sir.

31:22Gary Brecka:Malia's getting her exercise today. She's doing really well. Thank you. I've done your 10X gene test actually just last week. No, a couple of weeks ago. And thanks to Dana White for promoting you, actually. So the first gene came out compromised. and I would like to hear from you what exactly is going on yeah so um you're talking about the MTHFR does the one yes affectionately called the motherfucker gene we've said canteen Lou and so we can say mother it stands for methylene tetrahydrofolate reductase just so you know the the MTHFR gene mutation is one of the most common gene mutations in the world.

32:09Gary Brecka:About 46 % of the population, men and women, have this gene mutation. It is an inability to methylate, to break down, to process folic acid, and to a lesser extent, folate. And while that doesn't sound like a big deal, folic acid is the most prevalent nutrient in the human diet now because of fortification and enrichment. And if you have an inability to break down the most prevalent nutrient in the human diet, not only does this accumulate in the blood, you have a deficiency in what your body needs, which is called methylfolate. The fascinating thing about this gene mutation is it is the worst gene mutation to have, but the easiest gene mutation to fix.

32:50Gary Brecka:Supplementation with methylfolate or folinic acid can completely return this gene impact to zero. It can neutralize the MTHFR gene mutation. Three days ago, well, four days ago now, the US FDA actually just approved a prescription strength of folinic acid for the first time for autism and for postpartum depression. I find it really interesting that we are prescribing the methylated form of folate to treat postpartum depression, which is caused by the folic acid that we give to pregnant women. So 90 % of OBGYNs, when a woman gets pregnant, will tell you, you need to take high doses of folic acid because that prevents a neural tube defect.

33:36Gary Brecka:That's patently false. If your body cannot convert folic acid into methylfolate, it will not only not prevent the neural tube defect, it will exacerbate anxiety, depression, anxiousness, postpartum depression. My sincere belief is that the vast majority of postpartum depression is directly linked to the prenatal vitamin because the onset of, by the way, postpartum depression onsets during pregnancy, not after pregnancy, even though it's called postpartum depression. And if you look at the incidence of, if you look at the research, for example, since everybody loves research, there are virtually zero studies, peer-reviewed clinical trials, linking elevated pregnancy hormones to postpartum depression.

34:17Gary Brecka:So why do so many pregnant women get postpartum depression? The vast majority of them had the MTHFR gene mutation and took high doses of folic acid. So the long and short of it is folic acid is your enemy. you want to cut out fortified or enriched foods eat the organic version of those foods and supplement with something called methylfolate to neutralize that gene hey guys let me tell you about one of my favorite new hydration drinks now this is for distance athletes hits cardio exercisers people that sweat a lot or exercise intensely an a game is a hydration drink it has eight essential vitamins it has all of the electrolytes the entire suite of b vitamins before you freak out and read that it has 21 grams of sugar, which it does, the sugar is coming from natural cane sugar and honey, my preferred mechanisms for getting glucose into the blood during intense exercise.

35:06Gary Brecka:It also has natural flavors, but these natural flavors don't come from bacterial fermentation. They actually come from real citrus fruits, and the color is from vegetable juice, not artificial dyes. So next time you're looking for a great hydration drink and you're exercising intensely, A-game is your choice. Now let's get back to the Ultimate Human podcast. I mean I think if anyone I think that's good I mean you know without even testing I would say you should always take a methylated oh yeah yeah I think you should always take methylated if anybody is taking B complex or a B9 or B12 I would always take a methylated version just so you'd just in case you don't know as Gary said it's really how many what's the percentage of people 46 % yeah so you you know it's a lot of times you know things start with good intentions we wanted to you know people had a folate deficiency so we created a synthetic version called folic acid.

35:57Gary Brecka:A lot of people have B12 deficiencies. So we created a synthetic form of B12 called cyanocobalamin, which by the way, is also a nutrient you should never put in your body. If you spin your supplements or your protein powders, your energy drinks around, and they says cyanocobalamin, throw that in the trash, right? Cyanocobalamin is It's a cyanide-based form of B12. Yes, we take hydrogen cyanide, hydrogen cyanide. We bind it to the cobalt metal, which is B12. When you put that in the body, it's called cobalamin. Cyanocobalamin is cyanide and cobalt metal combined to make B12, cyanocobalamin. If you actually looked at the patents that protect manufacturers, that manufacture cyanocobalamin, their patent is on extracting the hydrogen cyanide from human sewage i used to show these patents on on previous um uh uh talks that i would do stage talks i would do i would actually just show the cyanocobalamin patent because if if you want to make something really inexpensively you take waste from another industry and you use that as your raw material so somebody is discarding something and you have a zero cost of product that's that's that's the panacea for profitability and so cyanocobalamin is virtually it costs nothing to produce and we mine the hydrogen cyanide from human sewage it's called sludge it's actually the discarded waste product from human sewage treatment plants and then we take that hydrogen cyanide bind it to the cobalt metal call it cyanocobalamin the body can't use cyanocobalamin the first thing your body will do is cleave the hydrogen cyanide molecule off break off the metal the cobalt metal and it will take that cobalt metal and it will put it into a physiologic transaction very necessary b12 is a metal by the way like zinc and magnesium it's not a it's not a vitamin it's a light metal um and then you're left with a floating cyanide molecule so how does that exit the body how does cyanide get out of the body well it takes zinc and magnesium and carries it out of the body so just imagine like inviting somebody over for dinner and you have a nice dinner and then before you leave they go in your closet they take your purses they take your watches take the cash out the safe and they leave that's what we do we invite these thieves into our body and they steal on the way out that's a great it's such a good way of explaining it's a really nasty analogy but at least you won't eat cyanocobalamin anymore yes sir all the way in the back

38:29hi my question is a hair lost a lot of lately my clients complain about that and also alopecia and benefits of exosomes and red light therapy. For hair loss, for alopecia. I suppose, again, the question is what's driving it. Is it for you? My clients. Your clients. Oh, okay. Because I was going to say, there are things, thyroid's a really common one that I see in my clinic. Stress is a really common one. And then I would say red light is quite useful for it. Alopecia's difficult. I find alopecia, if I'm being honest, I find alopecia complicated. So I work with the whole body, but I don't treat alopecia directly because I honestly find it difficult, so I'm glad to hear what you say.

39:20But hair loss, I look at thyroid usually.

39:22Gary Brecka:Yes, so alopecia, which is commonly called diffuse alopecia, is actually a maternally inherited gene predisposition. So you inherit it from your maternal side, not your paternal side. So if your mom's brothers are bald, watch out. so you can actually blame your mother for this one because it's carried on the maternal gene so that's diffuse alopecia but in the absence of the genetic inheritance the predisposition for alopecia so my mom's brothers are bald so I have a natural hair thinning the worst thing that you can do is propicia finasteride right because a second leading cause of alopecia in men is something called DHT, dihydrotestosterone.

40:06Gary Brecka:So DHT is what binds to the hair follicle, eventually chokes it out, makes it thinner, thinner, and thinner, and it eventually causes the hair follicle to die. What's interesting about the hair follicles is they take about 10 years to die, to become necrotic, meaning they can't be brought back, but they're dormant for over a decade. So very often, exosome treatments applied to the scalp can actually restore the hair that you had 10 years prior going back more than 10 years is virtually impossible because now those follicles have become necrotic but also the idea of suppressing a normal hormone in the human body dihydrate testosterone for the exchange of getting hair because the byproduct of that is impotence and erectile dysfunction so most of us want healthy hair so we can get a nice chick and then we get the chick and then the plumbing's not working right so it's good it sort of like defeats the whole purpose it's like you know I want to meet a nice lady at the bar so I need a nice thick head of hair and I got a thick head of hair and nothing's going on south of the border right so so instead of using Propecia or finasteride which will crush your level of DHT to stop it from binding to the hair follicle you can do things like exosome treatment or you can apply these topically they make liquid faster ride which can be applied topically is very effective for alopecia in men and in women i would also encourage women not to take finasteride especially orally there's all kinds of hormonal dysregulation that occurs when you take these these pharmaceuticals but applying it to the scalp allows a high concentration to get to the follicle stop the dht from binding and very little of it enters the serum of the blood so you don't have the hormonal consequences.

41:47You're welcome. Yes, sir.

41:54Gary Brecka:What's the difference in your recommendations for someone who wants longevity versus someone who's sports performance? So you've got like an endurance athlete and the carbohydrate intake they might need would differ from someone who's just purely got a longevity goal. So I think the performance versus longevity equation is an interesting one right I mean because there are many things that we can do to borrow from our future and if you borrow from your future you get present day return but you have a future consequence so I see this all the time but you know as I said in the previous talk I'm the health services director for the NFL Alumni Association so we have 22 ,000 athletes in our organization I know exactly what happens when athletes that desperately need to perform borrow from their future.

42:37Gary Brecka:They take exogenous growth hormone. They take exogenous anabolic steroids, and they perform incredibly well. You know, sorry to bust anybody's bubble, but you're not 265 pounds and running a 4-4-40 unless you are supplementing with exogenous, you know, support. And so lots of things borrow from our future. We do this to our skin in the forms of chemical peels, retinol, and other kind of chemical compounds that give us a short-term benefit but for a long-term consequence. So if your focus is on longevity, then I think that you should be exercising for longevity, lifting heavy weights but not doing compound movements.

43:19Gary Brecka:Like, for example, I used to love CrossFit and I actually owned a CrossFit gym. I have no problem with heavy weight and I have no problem with speed. I have a problem with speed and heavy weight. Deadlifting for time with a 400-meter sprint in between. those are just recipes for for disaster so a longevity protocol would follow the big data right whole food diet focused on sleep really focused on your community your relationships the depth of your relationships looking at things like the harvard study the longest longevity study ever done on the planet which said that the actual depth of the relationships that you have determine your life expectancy i'm a deep believer in that the whole front row is filled with my family I take my family everywhere just a deep meaningful relationship with my family and then so I like to keep them in close proximity um but uh I actually forgot your question I'm just rambling so sorry sorry why don't you just answer it you're just loving your family what did he say longevity and then I started thinking about my wife and now I'm like I'm all lost I think obviously um And if you've got an endurance athlete, you need a lot of carbohydrates.

44:27Yes. Like blood-produced storage. Yes.

44:29Gary Brecka:But your program is more about fasting. It's more about how do you get the correct amount of carbohydrates to perform at a high level in endurance sports, but also do it in a way that's healthy? That's a great question. So, you know, when you talk about endurance athletes, there's a difference, right? Because it's all about intake and utilization, right? So when intake meets utilization, you have homeostasis. When intake exceeds utilization, you have imbalance. And so I'm not a fan of very high-carbohydrate diets because I actually don't live a high-carbohydrate lifestyle. I do do intense exercise, but in very short periods of time.

45:10Gary Brecka:Hits cardio exercise for me is 20 minutes. And so your utilization matches your intake. Most people eat excessive carbohydrates, but they actually don't have the energy expenditure to burn those carbohydrates. It is absolutely necessary for performance athletes to take in high doses of carbohydrates. It's very, very hard to be a ketogenically powered endurance athlete. It's virtually impossible. Lance Armstrong tried it for a while and it was a disaster. So in performance athletes, using high glycemic carbohydrates right prior to enduring performance is almost a must. Um, but for the average, for most of us that are not endurance athletes, you know, if our intake exceeds our utilization, um, we have issues.

45:56Gary Brecka:You know, we talked about this before, you know, people that live at altitude, for example, have a tendency to have longer life expectancies. Why would living in less oxygen give you a longer life expectancy? Because your oxygen intake meets your oxygen utilization. So you have less oxidative stress. Yeah. I mean, it's, it's really true when you're doing endurance, you know, you have to refuel and, you know, you have to feel correctly for your muscles to work you need the glycogen in the muscles for it to work so it's exactly that it's what you said it's input and output um and they should balance um so and i think and i also think actually there are periods in people's lives when endurance is good it sort of pushes the body and i think then but i think like anything if you do it to the max for a long time then it starts to blunt that long you know that health span potentially um but i I think for some people and at different periods of life, you know, endurance is easier to do.

46:51Oh, sorry, we're getting... Okay, we've got a couple more minutes left.

46:55Gary Brecka:Let's get... Yes, ma 'am, right here in the front. Thank you. My question was about Alzheimer's and dementia. So my mum's got PICS disease, and she's had it towards the end of her life. But going forward, I'd like to know your thoughts about inheriting this and how you can potentially prevent it or avoid it through diet? There are some genetic predispositions to early onset cognitive decline, specifically Alzheimer's, and some predispositions for dementia and even Parkinson's. But your genes are not your destiny. And we know now that Alzheimer's is type 3 diabetes. It's insulin resistance in the brain.

47:41Gary Brecka:In fact, if you Google type 3 diabetes, you'll see that that is Alzheimer's. And, you know, the brain is crack addicted to insulin, right? And so most people, I mean, sorry, it's crack addicted to sugar. Most people don't realize this, but it's not just the pancreas that makes insulin. The brain also makes its own insulin. And it is such a voracious utilizer of insulin. I forget the percentage, but it's a vast percentage of the carbohydrate in your body is actually utilized by the brain. when you have a high glycemic profile high blood sugar and high insulin over a prolonged period of time what this leads to is something called neurofibrillary tangles neurofibrillary tangles eventually lead to something called amyloid plaques which are plaques that build up in the neurosynaptic junction they impede the communication between nerves it's a complete fallacy that people that have alzheimer's or dementia are losing their memory they're not losing their memory They are losing access to their memory.

48:39Gary Brecka:And access can be restored. At no time is the hippocampus actually losing its memory. It's losing access. It's losing the communication to prefrontal cortex and the rest of the brain. And so we call this memory loss. But it's actually not memory loss. If you've actually known somebody that has Alzheimer's, if you've had that misfortune, in all stages of Alzheimer's, even the most advanced stage of Alzheimer's, there's times where they do things called sputtering. so you've walked into their room 15 or 20 times you're their only child they didn't even recognize you they don't remember anything they have flat affect they have a blank stare and then all of a sudden they talk to you and they say something so cognizant they'll say do you remember that day that we took the boat out and we caught that fish and aunt betty was with us and you know and we went back and we had a drink at this place and we went back to the house and you're just your mind is blown because for that moment there's such clarity and such cognizance it shows you that the memory is still there, the pathway to the memory is what we need to regain access.

49:38Gary Brecka:So if I had a predisposition to Alzheimer's, dementia, or any early form of cognitive decline, which is eventually a neuroinflammatory disorder, I would actually highly focus on keeping my glycemic profile as low as possible. I would really focus on being insulin sensitive, not being insulin resistant. I would try to keep my hemoglobin A1C, the three-month average of my blood sugar, below 5.2. And I would really focus on keeping my insulin in the single digits. So you can do that through a myriad of ways, controlling your carbohydrate intake, intermittent fasting, because that is what is going to extend brain health and keep your cognitive function as long as possible.

50:21Gary Brecka:Listen, there's what I share on this podcast. And then there's what I share with my inner circle. If you've been following me for a while, you know how I hold nothing back here. But my VIP community, that's where the real magic happens. Picture this. You're struggling with energy crashes, brain fog, or just feeling like you're not operating at your peak, and you don't know where to get real answers. But here's what really sets this apart. You're not just getting my insights. When I have incredible guests on the podcast, VIP members get to submit questions for a private podcast segment. So that world-renowned expert we just interviewed, you get exclusive access to their knowledge, tailored to your specific situation.

50:58Gary Brecka:This section is under the private podcast section in the Ultimate Human Community. And speaking of exclusive, you're getting my personal protocols, the exact tools I use for water fasting, gut optimization, and morning routines that have taken me decades to perfect. This isn't theory. This is what works in the real world. The community launches challenges throughout the year where you get direct access to me and my network of experts. It's like having a personal health advisory board for less than$100 a month. Your health is your wealth, and this investment pays dividends for life. Join the VIP community at theultimatehuman.com forward slash VIP and step into your ultimate potential.

51:34Gary Brecka:Now let's get back to the Ultimate Human podcast. I mean, I think fasting is really key here and making sure you take breaks in between food. Because if you're eating, grazing, snacking is such a, it's an epidemic. It's crazy. And what that does is it keeps your blood glucose up. That keeps your insulin up and it never comes back to baseline. So in order to get that insulin sensitivity, keep your eating window tight. whether that's 10 hours, 8 hours, 12 hours, but then in between the meals really don't graze. It's a mind over matter thing. You don't need to graze if you're having complete meals.

52:08You won't need to graze. And the other thing that I would say is sleep, getting that glymphatic reset. So if sleep is really poor, because that's where the plaques can build up if you're not getting proper sleep. So really trying to clear those plaques out when you're having a good glymphatic reset. So prioritize sleep.

52:24Gary Brecka:Very high correlation between sleep deprivation and early onset Alzheimer's. You know, Ronald Reagan used to brag about only getting five and a half hours of sleep a night. And we know what happened to Ronald Reagan. Margaret Thatcher used to brag about only getting five hours of sleep a night. And we know what happened to Margaret Thatcher. So I'll end by saying something that's very, very controversial. But this is, it's gonna be very controversial. But I will tell you this, I am as resolute and certain of this from the big data in the mortality research that we did for 22 years. And we developed something called the variable basic table, which is the table that's used to predict all life expectancy now.

53:03Gary Brecka:So all annuities, all life insurance, reverse mortgages is based on this mortality table. In this mortality table, we used no randomized clinical trials. We used no clinical data from big pharma. We didn't study chemicals, synthetics, or pharmaceuticals. We actually studied big data on death and disease process. and there is an enormous correlation between the use of statins and early onset cognitive decline, Alzheimer's, and dementia. I'm not a physician. I am not licensed to practice medicine, so I can't give medical advice. But if someone I knew or loved had a predisposition to Alzheimer's, I would not allow them to be on a statin drug.

53:47Gary Brecka:Very often what you will see within the immediacy of a few weeks of stopping statin medication is a return of the cognitive function, like a light switch went on. And it's very controversial because we have not studied purposefully, in my opinion, very corruptly, we have not studied the long-term impact of statin use on cognitive function. But you see an increase in amyloid plaques, an increase in neurofibrillary tangles, an increase in neurodegenerative disorders, a decrease in memory, a decrease in focus and concentration. The vast majority of the brain is made up of cholesterol. Cholesterol is manufactured by the liver.

54:24Gary Brecka:It is not a toxic compound in the human body. In order for cholesterol to be toxic, something has to cause it to be toxic. It has to be oxidized. Cholesterol on its own is not dangerous. Driving it down into the low double digits is what we found in big data, one of the leading causes of the parabolic rise in Alzheimer's. A lot of people I know are going to find that very controversial. I've had many, many, many an argument with a physician about that. But I will tell you that is patently true. And in another 10 years, the clinical research through artificial intelligence will prove that. Okay, so one more question.

55:00Gary Brecka:Yes, ma 'am.

55:04Gary Brecka:First of all, I love this audience, because I say really controversial stuff, and nobody gets up and walks out. I literally I literally have doctors like get up and walk out of my... The thing with the statins thing too is that the data does show that when you look at who it actually works for when it's been prescribed, when you take out all the things, you get down to N1 in 25 ,000 or something. You know, it actually is, if you go and look, even for treating high cholesterol, it doesn't, it's a very peculiar one. And I can, if that's not, you know, that's what the data shows. And I'm not a physician either, but you go and have a look.

55:36And it's really interesting that it's the most prescribed pharmaceutical.

55:39Gary Brecka:It might have something to do with the fact that it's a trillion dollar industry. Yeah, maybe. I'm just throwing that out there. Yeah, it's possible. Yeah. So you've mentioned yesterday that you don't prepare a long time keto diet. Would you explain why? And my second question that my friend is pregnant now, but she has graves before. And she has done a recent blood test and her TPO and trap are high. So, and all the prenatal supplements are containing iodine. So my question, is it safe to take it? Or what do you think about it? So she has thyroid peroxase antibodies. She has the TPO antibodies.

56:24Gary Brecka:So the first question I would be asking is, what called the immune system to the thyroid? Remember, the immune system doesn't just show up for no reason and kick down the door of a cell, right? It's like if this building never caught fire, the firemen would never show up. If it did catch fire, the firemen would show up. So the question is, what called the immune system to that location? Very often in the case of thyroid, thyroid has a special affinity for heavy metals, especially mercury, but also palladium, cadium, nickel, boron, I mean cadium, nickel, and lead. And so these metals, which, by the way, are usually low detection in the blood, Heavy metals don't just hang out in the blood and wait for you to urinate them out.

57:09Gary Brecka:They gravitate out of the blood and they enter the tissue. The thyroid has a special affinity for heavy metals. When heavy metals embed themselves in the tissue, it calls the immune system to that site. And when the immune system arrives on that site, because it's hypervigilant, very often the consequence of heavy metals embedded in the thyroid is that it lights up the immune system and it causes an autoimmune response. And then what we say is the immune system would hire for no reason at all. It just manufactured antibodies to your thyroid one day for absolutely no reason. You went to bed, you woke up, the immune system went haywire, and now you have this disease, Graves' disease or Hashimoto's disease, because your immune system doesn't know the difference between friendly tissue and foreign tissue.

57:52Gary Brecka:I would argue that if you don't know the reason for that, that we should be doing the testing for the big four. And I call these mold mycotoxin, parasite, virus, and heavy metal. in nearly every case that we have done a search for those four things you find the cause of what called the immune system to that location so that's where i would um begin yeah i agree that's what we see oh in the keto diet long term so um ketosis is very very safe everybody in this room came into this world on a keto diet the first 48 hours of uh you know colostrum mother's milk is entirely ketogenic the vast majority of our brain is ketogenic we can survive on fats indefinitely remember there are two essential fatty acids they are essential for life there are nine essential amino acids they are essential for life there is no such thing as an essential carbohydrate so again if you just marinate on that thing that for a second there is no such thing as an essential carbohydrate so carbohydrates are not essential for life there is no carbohydrate that we need to live or to survive.

58:57Gary Brecka:That being said, it doesn't mean that we shouldn't eat carbohydrates. It's just that we should be the most judicious with our carbohydrate choices. So ketosis is when your body switches from burning sugar as a source of fuel to burning mainly something called beta hydroxybutyrate as a fuel source. And beta hydroxybutyrate is a very clean fuel source. When it burns, your body makes a type of water intracellularly called deuterium depleted water. If you really want to have some fun, just Google deuterium depleted water when you get home and you'll be fascinated at the implications. You know about deuterium-deplated water?

59:31Gary Brecka:You'd be fascinated at the implications of this light water in cellular biology. Because our cellular biology, specifically our mitochondria, makes 100 gallons of intracellular water every single day. It's hard to conceive because you only drink maybe a half a gallon of water a day. So how do you make 100 gallons of water a day? You make water in the mitochondria the same way we make it in space. You take two hydrogen, one hydrogen, or two hydrogens, one oxygen. you bind them together you have a water molecule so you create it out of the gases it passes through the mitochondrial wall and then it gets used in something called the krebs cycle which is what generates the energy source that human beings are powered from called atp and so um in short term it's it's an excellent way to reset the system type 2 diabetics people with hypertriglyceridemia very high triglycerides they do extraordinarily well on ketogenic diets The challenge with a ketogenic diet, it is virtually impossible to maintain over prolonged periods of time.

1:00:28Gary Brecka:A keto diet is not a diet that you can date. You have to marry it. You cannot cheat on it. You have to be in a committed relationship. This is my favorite one. People are, I'm doing keto all day, and then they get to the evening and they eat a tub of ice cream. And so then they're high fat, high protein, high carbohydrate, high sugars. And because it's hard to maintain, you have to know what you're doing. But it is really effective. so I will use it a lot with cognitive issues actually, you know, because it's really good. It really helps if someone's got cognitive. I mean, it's very good for ADHD and things like that, but it's hard to maintain it.

1:01:01And also I would say, you know, I know that fibro and carbohydrate are essential for, but they're really, really important for the gut and for our microbes. They're essential for the microbes. So, you know, I think I do know, and it comes back to really basic stuff of how do you want to live your life and do you want to be measuring and counting? And I think it's an amazing tool to have in the toolbox if you need it. I think so, too. It is, isn't it? Yeah. You know, rather than a lifestyle, I think.

1:01:29Gary Brecka:I mean, that's what saved Dana White's life, right? He had fasting triglycerides of 800. My daughter's sitting right there. I'll never forget the day. She's also a nurse. I called her out twice now. But I'll never forget the day that, you know, she was with me three years ago when we drew Dana White's blood. She was the nurse that took his blood. And I'll never forget, you know, when you draw somebody's blood, You set the tubes on the counter for half an hour, then you put them in a centrifuge and you spin them down. And I was sitting, Dana White was sitting in front of me, and she was around the corner.

1:01:58Gary Brecka:And she goes, oh, my God, Dad, Dad. And she was pointing at the vial of blood, and she turned it upside down and had already coagulated. So his blood was solid at room temperature. Fasting triglycerides of 800 is almost a medical emergency. So you should have been a fly on the wall when I had the conversation with Dana, where I said, you have so much fat in your blood that I'm going to put you on a high-fat diet to lower the fat in your blood. He was like, you know, like, what are you talking about? It makes no sense. You're going to eat 75 % of your calories from fat, and then all the fat is going to go out of your blood.

1:02:34Gary Brecka:He's like, that makes no sense. I go, I know, but it'll work. And that 10-week ketogenic reset, I truly believe was life-saving for him. So it can be an amazing way to restore cognitive function and reduce inflammation. to lower triglycerides, but you do want to start reintroducing carbohydrates, especially things like fermented vegetables and things which are really, really good for your gut. I also think it's quite good to try these things to get your metabolic flexibility, to see what works for you. I think it's really, you know, I mean, I love trying different. I think it's interesting to learn from your body and also to get into a ketogenic state takes time.

1:03:10So people who do it for, you know, to get into a true ketosis takes time and you can feel absolutely awful for a few days. They call it keto flu. So if you're going to go through all that and only do it for 10 days, I'd suggest you do it for a bit longer and sit with it, feel it, see how it feels, try it on, see if it works for you, and then perhaps bring it back just so you have mild ketosis.

1:03:32Gary Brecka:And can I just give one more tip on the keto diet? So because you brought up the keto flu, the keto flu comes from the fact that in ketosis, your kidneys use four times the amount of sodium to process fatty acids, beta-hydroxybutyrate. than when you have carbohydrate as a fuel source. So your sodium need quadruples is critical to supplement with a mineral salt, like a Baja Gold mineral salt. By the way, if you guys haven't gotten a free shaker of Baja Gold, please, on your way out, there's 600 of them back there. Grab them and take them home. They're free. But it's absolutely critical to significantly increase your sodium intake on a ketogenic diet.

1:04:10Gary Brecka:If not, you will get the keto flu. Okay, so would that stop it then, doing that? I didn't know that. It helps it deaden its drugs. Oh, that's so interesting. You won't get the keto flu if you take it. See? We learned something new today. Awesome. Thanks, Gary. So one more question, then we'll wrap up. Yes, ma 'am.

1:04:28Gary Brecka:That's okay. What would be a good protocol to get rid of heavy metals and how long we should follow that for? So did you do my genetic test? I bought it. Okay. So if you bought my genetic test, That's the only reason why I'm asking is you bought my genetic test. I also gave you a month free of my VIP community. In my VIP community, I wrote an eight-week guide to mold detox and a 12-week guide to heavy metal detox. It's very specific. I tell you what gut binders to use, how to test for the metals, because the vast majority of testing for heavy metals does not give you the correct metals in the blood.

1:05:05Gary Brecka:There's something called an oligo scan that scans for metals in the tissue, and there's something called a provoked urine, which is the best way to test for heavy metals. So all of that is in there. And if you follow that, you can detoxify from all of the heavy metals. And it's free since you bought the test. Guys, thank you so much for your time. Thank you so much.

From the publisher

Think gluten is your enemy? The real culprit behind your sensitivity might shock you, and it’s hiding in almost every processed food labeled as “enriched” or “fortified.” In this unfiltered nutritional Q&A, Rose Ferguson and I answered questions on chronic disease, cognitive decline, metabolic dysfunction, gut-skin-brain connection, metal toxicity, and more!

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Timestamps

00:00 Intro of Show

03:11 What supplements are best for my teen at boarding school?

06:58 If I need 150g of protein, how much can come from shakes?

16:33 Can nutrition help reverse conditions like rosacea?

21:51 For vegans, what lesser-known things should we consider?

25:42 What nutrition supports people with ADHD best?

31:31 What does the MTHFR gene mutation mean for health and how does it affect folate processing?

38:31 Is hair loss or alopecia normal, and can exosomes or red light therapy help?

41:52 How can endurance athletes balance carbs, fasting, and health?

47:00 How can we affordably prevent or manage Alzheimer's?

55:49 Why avoid keto at night, and is iron safe if ferritin drops?

01:04:30 Can heavy metals be fully removed, and how long does it take?

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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213. Rose Ferguson: Q&A on MTHFR Gene Mutation, Autoimmune Disease, Cognitive Decline, & More!The Ultimate Human with Gary Brecka · 1 h 5 min
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