294. Dr. Deep Sea: Hyperbaric Chamber Benefits Nobody Explains Correctly

11 Aug 2026 · 1 h 26 min · 31 chapters

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In short

Hyperbaric chamber use as a “hormetic stress” for longevity/brain health, emphasizing pressure/oxygen protocols, safety, and mechanisms (mitochondria efficiency, mitogenesis). The episode also covers Dr. Duturi’s self-experiment outcomes and his role in large randomized TBI trials, plus the XPRIZE healthspan competition.

Guests

Dr. Duturi (aka “Dr. Deep Sea”), a Navy diver turned biomedical engineer/PhD researcher. He reports a 2023 world record: 100 days at ~22 feet underwater near the Florida Keys, with extensive self-measured physiology (blood/urine/saliva, EEGs, etc.). Host is Gary Brecka (“Ultimate Human Podcast”).

Key claims

Hyperbaric oxygen “doesn’t cure anything,” but helps the body “help itself.” Benefits come from intermittent hormetic stress, not “more is better.” Different pressures target different mechanisms (anti-inflammatory at lower pressures; oxidative killing at higher). He argues air-only chambers around ~1.3 ATA can still increase stem cell circulation.

Notable examples

1) Self-reported telomere length increase (~17%) and stem cell increase (~1,000%) after the 100-day dive (N-of-1). 2) A cited air-only study at 1.27 ATA: five 1-hour sessions doubled circulating CD34+ stem cells. 3) Ongoing USF TBI trial: placebo-controlled, randomized, double-blind; ~40 treatments over ~2 months. 4) XPRIZE: Team Healthspan (ASU) finalist; aims to extend healthy lifespan by 20 years.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Understanding Hormetic Stress and Hyperbarics

0:00 to 1:24

Learn how hormetic stressors like hyperbaric therapy can enhance mitochondrial efficiency.

“The simple truth here is that your life is supposed to be hard.”

Exploring Dr. Duturi's Journey

2:20 to 4:00

Discover Dr. Duturi's unique background and his quest in hyperbaric medicine.

“A lot of people was when Joe Rogan was talking about you on a podcast.”

The Mechanisms of Hyperbaric Therapy

4:00 to 7:00

Delve into the mechanisms of action and applications of hyperbaric oxygen.

“Is that what sparked your interest in hyperbarics?”

Hyperbaric Protocols and Their Effects

7:00 to 11:00

Examine the effects of varying hyperbaric protocols on body mechanisms.

“I was one of the members when I was the assistant vice president of the University of South Florida.”

The X Prize and Longevity Research

11:00 to 14:03

Learn about the X Prize challenge aiming to extend healthy lifespan and its implications.

“And nobody really knows the real answer.”

Introduction to Hyperbaric Chambers

14:03 to 17:12

Learn about the unique design and function of hyperoxic hypoxic chambers.

“I'm putting these in all my ultimate longevity centers.”

Benefits and Science of Hyperbarics

17:21 to 26:10

Explore the physiological benefits of hyperbaric therapy and its scientific backing.

“So hyperbarics are providing a hormetic stress.”

Safety and Efficacy of Hyperbarics

26:10 to 28:00

Understand the safety measures and potential risks associated with hyperbaric treatments.

“So I want to resist that, especially when it comes to hyperbarics.”

Metabolism and Underwater Experience

28:00 to 28:50

Discussion on the effects of hyperbarics on metabolism and weight loss during underwater stay.

“When I stayed underwater, first of all, in the first 25 days, I lost 22 pounds.”

Sleep Quality Underwater

28:50 to 30:24

Exploration of deep and REM sleep phases while staying underwater and their health implications.

“but we talked about, you talk about deep and REM sleep.”
Show all 31 chapters

Scientific Measurements and Results

30:24 to 31:56

Insights into various scientific measurements and notable health improvements during the underwater study.

“Now, if you've not set up your own EEG, your new EEG, beautiful, brilliant.”

Effects of Oxygen Saturation on the Body

31:56 to 34:06

Discussion on adaptation to increased oxygen levels and effects on hemoglobin and energy levels after returning to sea level.

“I'm not saying that I did, but, you know, boss, don't yell at me.”

Hyperbarics and Hormetic Stress

34:06 to 35:35

Exploration of the benefits of hyperbarics, including hormetic stress and its role in health.

“Probably not, but can it be good for you?”

Research on TBI and Intermittent Hypoxia

35:45 to 39:00

Discussion on ongoing research related to TBI and the effects of oxygen deprivation on VO2 max and longevity.

“Now let's get back to the Ultimate Human podcast.”

Personal Anecdotes on Health Practices

39:00 to 41:22

Sharing personal experiences and observations on the effects of various health practices on family members.

“But what you're saying is there is probably increased mitochondrial efficiency.”

Advanced Hyperbaric Techniques

41:22 to 42:00

Discussion on new hyperbaric techniques, including varying pressure and its implications for health.

“But my mother goes to the gym every morning.”

Exploring Hypoxia and Hyperbaric Therapy

42:00 to 44:11

Learn about the protocols and benefits of using hypoxia and hyperbaric therapy for health and performance enhancement.

“And I've used it, clients of mine, for post-surgical recovery, for athletic performance.”

Mitochondrial Efficiency and Performance

44:11 to 49:47

Discover how hypoxia affects mitochondrial function and the implications for performance and longevity.

“so then you definitely run out of two atmospheres when you deprive them of oxygen.”

Safety and Efficacy of Hyperbaric Treatments

49:47 to 52:26

Understand the safety measures and efficacy of hyperbaric therapy, including research findings and personal experiences.

“So when you do that, you can make the mitochondria more efficient.”

Future of Hyperbaric Therapy and Cognitive Enhancement

52:26 to 56:00

Discuss the future applications of hyperbaric therapy for cognitive enhancement and the challenges in funding research.

“And so that's why I'm so excited about this podcast is like set the record straight, put some guardrails in so people can safely use these hyperbarics at scale.”

Understanding Traumatic Brain Injury

56:00 to 1:01:50

Learn about the complexities and historical context of traumatic brain injury and its treatment.

“And when we talk about traumatic brain injury, is this at the time of a concussive injury or is this traumatic brain injury from past traumatic brain injury and you're trying to recover function.”

The Role of Perfect Amino Pre-Workout

1:01:50 to 1:02:20

Discover the benefits of Perfect Amino pre-workout and its effects on performance.

“It was the best thing that ever happened to me.”

Benefits of Hyperbaric Oxygen Therapy

1:02:23 to 1:06:54

Explore the various health benefits of hyperbaric oxygen therapy, including skin health and collagen production.

“A lot of people are touting healthier skin, youthful appearance to the skin, the oxygen being provided to these dermal, subdermal layers of the skin, actually improving the appearance of fine lines and wrinkles.”

Future of Hyperbaric Therapy

1:06:54 to 1:10:01

Discuss the potential future of hyperbaric therapy as a commonplace health solution.

“Don't go in the chamber to go in the chamber to have your alone time and keep that and cradle it and make it yours and be like, nobody's touching my hyperbaric oxygen time because it makes me feel better.”

The Role of Hyperbarics in Oncology Treatment

1:10:01 to 1:11:59

Learn how hyperbaric oxygen therapy can be integrated into cancer treatment protocols.

“Does that mean it's gonna work for a bad arm wound?”

Metabolic Shifts and Cancer Cell Dynamics

1:12:00 to 1:16:38

Discover how cancer represents a metabolic shift and the implications for treatment.

“All cancer was at one time a healthy cell.”

Enhancing Immunity and Stress Management

1:16:39 to 1:19:58

Understand the relationship between immune function, stress, and overall health.

“And, you know, nothing can go wrong, in my opinion, by having a healthier, more efficient immune system.”

Integrating Various Health Therapies

1:19:59 to 1:24:00

Explore the benefits of combining therapies such as sauna, cold exposure, and hyperbarics.

“You have a worse speaking schedule than me.”

Maximizing Potential as an Ultimate Human

1:24:00 to 1:25:14

Explore what it means to be an ultimate human and living up to one's potential.

“She's like, yeah, don't anybody talk to me and I'll just go in here by myself.”

The Role of Hard Work in Longevity

1:25:14 to 1:25:41

Discuss the importance of hard work over quick fixes for longevity and health.

“I mean, if your research comes out the way that it looks like it is, you take the XPRIZE, 110s in your mirror.”

Clarifying Hyperbarics and Biohacking

1:25:41 to 1:26:16

Gain insights into hyperbaric chambers and their significance in biohacking.

“And I really appreciate you coming on and clarifying.”
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Transcript

Automatic transcript. May contain errors.

0:00The simple truth here is that your life is supposed to be hard. Hormetic stressors are there for a reason. All these hormetic stressors put together when you go to the gym, when you go to the ice bath, when you go to the red light, all that stuff is actually good for you. So when you do that, you can make the mitochondria more efficient.

0:16Gary Brecka:So hyperbarics are providing a hormetic stress. This hormetic stress applied intermittently seems to be having a very positive effect on the mitochondria, which to me would be the hallmark of age reversal. Hyper means more than, baric means pressure. That's it. You just increase the pressure, you get that benefit. Using gas, pressure, hormetic stress, these are all things that we have a lot of data on in terms of strengthening the body and improving performance and function. And I think most people are after that cognitive benefit as much as they are physical benefit. Hyperbaric oxygen doesn't cure anything, but it helps your body help itself.

0:55And that's what we want. We want an organism that will fix itself better.

0:59Gary Brecka:Where do you see the future of biohacking slash recreational hyperbarics going? The interesting thing that we just found out and we've come through, and the science isn't done yet on it, but...

1:23Gary Brecka:hey guys welcome back to the ultimate human podcast i'm your host human biologist gary brecca where we go down the road of everything anti-aging biohacking longevity and everything in between. This is an anti-aging longevity and biohacking and in between podcast. I've probably said this before, but I mean it today. I don't recall being so excited about a guest coming on my podcast because it happens to be an area where of the biohacking community that I think is just in its infancy. I think the implications of this biohack, if you want to call it that, are profound. He is leading the way in research, conducting some of the largest TBI studies ever conducted in the world.

2:08Gary Brecka:He's done experiments on himself, experiments on other people. He has a background in this biohack, and I am so excited to sit down with Dr. Duturi, aka Dr. Deepsea. How are you, my brother? I'm well. I'm well. Thank you. Glorious introduction. Most people heard about you. A lot of people was when Joe Rogan was talking about you on a podcast. He's like, you ever see this guy? This dude like lived under the ocean for like a hundred days. Hyperbaric chamber. Pulls up your story. And I've gotten to be good friends with Joe. I've been on this podcast a couple of times, but I saw that started going down the rabbit hole.

2:49Gary Brecka:Met your co-author, Dr. Sauners. Dr. Sauners. Yeah, this is the Bible of hyperbaric medicine. I'm so excited for this podcast. And your background is a Navy diver, left the Navy, went to school for biomedical engineering, suffered a TBI, I wanna say in 2023. 21. 2021. 2023 was when you set the world record. Yep. 100 days, 22 feet underwater, just south of me right here in the Keys. And if I recall, I remember reading some of the outcomes. This is what really zoned me in on hyperbaric therapy. You had a 71 % reduction in your cholesterol. You had like 1 ,000 % increase in stem cells. You had telomere lengthening.

3:43Gary Brecka:Yep, 17%. 17 % telomere lengthening. Albeit, this is an N of one. I get you science nerds out there, calm down. We're not making a medical claim. And then you lost like a quarter of an inch or half an inch, right? I don't know how you got shorter, but you did. So everybody's like, screw hyperbarics. I don't want to get smaller. Yeah, yeah. Is that what sparked your interest in hyperbarics? How did you get down the road of hyperbaric medicine? In hyperbaric medicine. Oh, wow. That's actually a great question. All right. So I was a Navy diver. We used recompression chambers. And then, you know, I got to mobile diving salvage unit.

4:24And when we're at one of these mobile diving salvage units, the doctor was like, hey, by the way, we're going to treat this old guy who's got a little bit of cancer in his jaw. I said, we're going to treat him. And I said, wait, wait, wait, you can treat these guys. I was young, right? It was like, you can treat other people in high, not just decompression sickness. And it's like, we're going back a million years too, right? So I was like, really? I'm interested. Let me tell me more, tell me more. So she starts telling me more, more, more, more, more. All of a sudden I'm like, oh, at that time there were 12 approved indications.

4:56Now there's 15, right? On label FDA cleared sort of indications. And now it's like, oh, wow, we can use this for other things. This is a very powerful drug. So I stepped back and I go, what are the mechanisms of action? And everybody's looking at me like I got 10 heads. And I'm like, no, that's how we prescribe every drug in the world is by its mechanism of action. And they're like, oh, so that's kind of - We don't know. We just know that it works. We know that it works. I'm like, well, science wins over bullshit. Let's fix that.

5:23Gary Brecka:Yeah. Okay. So that's, because you didn't get your PhD until you got out of the Navy. Oh, yeah. Right? And so something must have led you in your later adult time to say, I want to go into biomedical engineering and get this PhD, which most people don't wake up midlife and decide that they want to do that. So what had happened was - What had happened was... I'm retiring and we're talking with Admiral Bill McRaven and another friend of mine, Admiral Ed Winters. And they're like, hey, what are you going to be when you grow up, Aquanaut? And I'm like, well, I don't know, but I don't want to come work for you.

5:57He's like, no, no, no, help me because can you sit on the preservation of the Forsen family? And I said, okay, that sounds good. So we dealt with people with TBIs and this is a great thing, right? Here we are, we're helping our guys, right? I'm retired, I'm the old gray beard sort of at this point. And they're like, yeah, yeah, yeah, we can push you down.

6:14Gary Brecka:Veterans with TBIs, yeah. Veterans with TBIs and even active duty guys with TBIs and how do we fix that, right? So Admiral McRaven was terrific because he wanted to look at the preservation of the force and family, right? So he was looking at this whole setup trying to make everybody better. Okay, great. So I go back to after six months and I talk to him and I go, look, this is just not working. And I says, and he looks me dead in the eye and he goes, permission granted, Aquanaut, fix the problem. And I'm like, oh shit, now I gotta go back to school because I'm not smart enough for this. So I go back to school, I get a PhD in biomedical engineering and then I start doing clinical research in traumatic brain injury.

6:52And it's like, okay, that worked.

6:54Gary Brecka:Wow, and now you're running the largest TBI study ever conducted at USF, right? I'm not running it. I was one of the members when I was the assistant vice president of the University of South Florida. I stepped away from that in December only because it's now moving, right? Now it's moving. it's time to let i'm a i'm a doer not a not a talk about doing so right academia moves a little slow yeah yeah i want to go fast yeah i did i i feel you but this may be a very profound study when it's when it's published it will change things that's for sure and it was done with a placebo randomized double blind it's it's done the right way yeah it's all the bells and whistles so and as I understand, it's 73, 75 minutes, five days a week.

7:40Yeah. 100 % or two. Exactly. 100 % or two or placebo. Or placebo, yeah. Yep. Air at zero feet. And, you know, we're doing it the right way. It's 40 treatments long. So it's basically a two-month-long protocol, if you will. And, you know, we'll see is the answer. And can you tell us what, let's talk about mechanisms of action.

8:02Gary Brecka:Sure. because I'm a fan of hyperbarics. I would say I'm a recreational hyperbaric user and I would like to become more than a recreational user. I've got hyperbarics in every home and I'm invested a lot in hyperbarics. Personally, I'd rather have a hyperbaric chamber than a Ferrari because I don't have a car problem or a watch problem. I have like a biohacking problem. That's why I keep telling my wife. I have a little biohacking addiction. If you see my garage downstairs, It's like a biohacking hoarder. You know, it's like one of those, like, you know, docuseries, you know, on hoarding. But, you know, I understand mechanistically we're increasing atmospheric pressure, which decreases the size of oxygen and other gases.

8:50Gary Brecka:And therefore they should be able to profuse tissues more thoroughly and probably in areas where they otherwise wouldn't get good saturation. So let's say connective tissues, ligaments, tendons, areas of the brain that are not served by healthy vascular flow, compromised blood flow, and people with vasomotor circulation compromise. I think the literature is super clear on post-surgical recovery, wound. There's a lot of information out there on diabetic ulcer, those types of things. Yeah, the common ones, right? The common ones. The osteonecrosis, the gaseous gangrene. They're like, oh, they're horrible.

9:32but they're really well looked after and they work.

9:35Gary Brecka:Yeah, especially if you have like an anaerobic infection, right? Yeah, that makes perfect sense, right? I mean, so logically you can put the mechanism of action with the treatment. So we have 13 known mechanisms of action. Let me step back and say that again. This is like a super drug. It's not like a super drug. It is a super drug. It's classified as a drug by the USP, right? US Pharmacopoeia says it's a drug. Okay, hyperbaric oxygen is a drug. But, you know, aspirin, what does that got? Three, four, five mechanisms of action. Gabapentin, three, you know. There's a couple of these that GLP-1s, there's three or four of those, increased cerebral blood flow, you know, it does the weight thing.

10:13But that's all great. Hyperbaric oxygen, 13. It is the super drug of super drugs.

10:20Gary Brecka:I don't even know what to say. Wow. And, you know, I was talking to Dr. Saunders about this too. Is it dose dependent, pressure dependent, do different things happen at different pressures? Is there an ideal pressure? Is there an ideal oxygen saturation? Because, you know, like I have a soft chamber in my bedroom. It goes to about 1.3-ish. I've got a hard shell in the gym that'll go to two atmospheres. I think it'll go higher. I think it's governed to two atmospheres. And I know that certain benefits occur at certain pressures, but one of the things that Saunders was telling me is like, it's not always more pressure is more results.

10:58Gary Brecka:it's different hormetic stress providing a different outcome. And I'd love to unpack that with you. Yeah, it's huge. And nobody really knows the real answer. So I'll be speaking in tongue on this, kind of just trying to figure it out. But realistically, we know that certain pressures do certain things. And what mechanism of action do you want to work? The more powerful anti-inflammatory natures, that seems to be in the lower pressures, the 1.345, something like that. The brain seems to tolerate 1.567 better than 2.0, 2.5, 3.0, right? But if you want hyperoxygenation as a mechanism of accident or leukocyte oxidative killing, you need to be in the 2.5 to 3.0 range, right?

11:42You want to crush the bubble, you need the more pressure, that kind of stuff. So there's a lot of different things. You just got to play with it, right? Here's the interesting thing that we just found out and we've come through, the science isn't done yet on it, but varying the hyperbaric oxygen protocol does different things and it stimulates that hormetic response.

12:04Gary Brecka:Well, now you're jumping to your X prize, right? I mean, so let's jump there. And then I want to go back to some of what you saw when you were 22 feet underwater, because that's not even quite two atmospheres, right? So that's like what, one five-ish? One six, one seven, something like that. One six, one seven. Because I want to talk about that because the outcomes were pretty profound. We'll go where you want. You're in charge. So let's jump to the X Prize. For those of you that don't know what this is, it's a$101 million winner-take-all prize. I believe this year's was to extend healthy lifespan by 20 years.

12:40Gary Brecka:Yep. That was sort of the framework. About 765 potential contestants. That's down under 100 now, right? Yeah, it got to 100. We were one of the hundred finalists that team Arizona State University health span, team health span. Okay. Yeah. And has that hundred narrowed or you'll know as - Not yet, we'll know in July. So fingers crossed we'll be the final 10. Yeah. If you split the hundred million with me, I'll grease some people behind the scenes for you. Do you know Pete? Do you know Pete? I do. Peter Diamantis, dude, come on, buddy. Give it to this guy. Come on, Elon Musk. So$101 million winner take all.

13:16Gary Brecka:and to add 20 years to healthy lifespan. And I love how they define that as not just lifespan, but healthy lifespan. So you're actually pushing the lifespan out with the health span, which I think is the hallmark of success in anti-aging. None of us just want to live another 30, 40 years. Yeah, who cares if you're a persistent vegetated state? I don't care. Yeah, exactly. I want to live shorter, not longer. And we want to be independent. We don't want to be assisted with the activities of daily living. We want independent living. It's like, how many healthy, independent years can I have? And then God call me back, you know?

13:53Gary Brecka:Exactly. So in this realm, you know, what I find fascinating is you, with HBO Tech, which I'm a huge fan. I have an HBO Tech hyperbaric chamber. I'm putting these in all my ultimate longevity centers. I think they're a fantastic manufacturer. Oh, yeah. You created and designed a one-of-a-kind, at least today it's one-of-a-kind, hyperoxic hypoxic chamber. And that means that you take a hyperbaric chamber and you provide the subject with oxygen deprivation and then oxygen excess. Yeah. Right? So, you know, for those folks that are watching, sea level is what, 21 % oxygen. So hyperoxia is gonna be above 21%.

14:40Gary Brecka:Hypoxia is gonna be below that or simulating altitude, right? I mean, the higher you go, the thinner the air. And you're seeing some pretty incredible results. Really great. Really great. I was reading your report, like 8.2 years, 8.6 years that you guys are at right now. Yeah, did they share that results with you? I don't know. Somebody told me it's just - You may or may not have seen it because I may or may not have been allowed to share it with you. Okay, so you didn't share it with me. But that is profound. hound, you're not far into this study yet. This is not a years long study. No, this is, and the cool thing is you give me 20 days, I can give you between eight to almost 20 years if you give me 20 days.

15:19Gary Brecka:20 consecutive or five on two off? 25 days on two days off, five days on two. So give me 30 days technically, 28 days, right? So 20 days of hyperbaric. 20 days of hyper hyperbarics, but it's not just that, right? The simple truth here is that your life is supposed to be hard. Everybody's trying to have the easy life. Everybody wants the grease streets. No, it's supposed to be hard. Hormetic stressors are there for a reason, right? To strengthen us. To strengthen us, exactly. We go to the gym, right? And we work out, right? Look at the guns, the gun show. So we go to the gym and work out, and we get that we accept failure in the gym because we need failure, right?

15:56But we don't do that in the rest of the areas of our life. So hypoxia, hyperoxia, you know, red light therapy is a hormetic stress. You know, we have cold plunge. We have the saunas, right? We have several of these things. The hormetic stress from eating the right kind of food that is stressed, right? Like what's the best tasting strawberry? The one that's been through the hard winter that really got stressed. That's the best tasting. And it's also the best for you. So that kind of hormetic stress from eating that kind of stuff. These are great things, but your body needs to go through this. We all spend one-third of our lives sleeping.

16:34Gary Brecka:One-third. That's 25 years of your life on a mattress, breathing it in, absorbing it through your skin. The U.S. mattress industry is the most chemical heavy in the entire world. 96 % of mattresses contain petroleum foams. 92 % use chemical flame retardants. You wouldn't eat that, so why would you sleep on it? The ultimate snooze is different. No petroleum, no fiberglass, no boric acid, just GOTS certified organic cotton and wool. 100 % natural Talalay latex and made in America. It's the only mattress that I back, Gary Brecca, because it meets my standards for human optimization. Sleep chemical free.

17:12Gary Brecka:Visit theultimatesnooze.com and use code ULTIMATE for 10 % off. Now let's get to sleep. Now let's get back to the Ultimate Human podcast. So hyperbarics are providing a hormetic stress. So let's just start with taking ambient air, compressing it, and then the atmospheric pressure is the multiples that you're providing this pressure. Just that alone, let's say not adding oxygen, not 100 % O2, getting in a hyperbaric chamber, soft chamber, let's say, that goes to 1.3 atmospheres. What are some of the benefits of that? I mean, more and more people are putting these in their house. They're getting these certified chambers, doing an hour and 90 minutes a day.

17:56Gary Brecka:What can they expect from it? What does the science say about regular use of hyperbarics? So PhD researcher went in, did five treatments in an air-only chamber at 1.27 ATA, which is basically like 10 feet. It's 10 feet under the water, right? You got one that can go that deep too, right? Just using air. Five days, one hour at a pop, he doubled the number of circulating stem cells. Wow. Five days. And this is, did the flow cytometry. This is real science. And you know me, science wins over bullshit, right? These are stem cells migrating from your bone marrow into circulation. CD 34 plus progenitor stem cells.

18:36Like this is the good, this is the gold card, right? This is the wild card, right? This is what you need. So, you know, now what does that mean? I don't know what that means. but doubling stem cells is not a horrible thing.

18:47Gary Brecka:Yes, yeah, absolutely. And so, and that was at 1.27. And then, you know, a lot of these chambers, 1.5, two atmospheres. So as you increase the pressure in a hyperbaric chamber, what's happening physiologically to the body, aside from the gas getting smaller? So look, you cannot squish the human body, right? I mean, basically you're made mostly of water and water is pretty much incompressible, right? At thousands of feet, it gets compressible, but that's not important, right? So, but you're incompressible, if you will. So as long as your gas spaces are full, you can, I mean, the deepest recorded dive is 2 ,265 feet or something.

19:26For a human? For a human. Oh yeah. My deepest dive is 1 ,947 feet.

19:31Gary Brecka:Your deepest dive? Yeah. That's like the, what was it? The Titanic thing that just crumpled like a can. No, that was 5 ,000 feet. That was 5 ,000. Okay, 5 ,000. No, that was crazy. You dove almost 2 ,000 feet? Yeah, I mean, so the deepest, dives that we do are, you know, we can go to 2000 feet. We can go to 20. I think the French just went a little deeper than that, to be honest with you. So it might be like 2300 feet now, but humans can go deep. That's not the problem. The problem is the gas mixture that you're breathing, right? Because when you go to twice the atmosphere, you're effectively breathing twice the oxygen concentration.

20:04Then the fire risk goes up. Then the, right? You know, you have the nitrogen narcotics, the narcotic potential. You know, we were talking about hydrogen gases. Everybody's like, oh, let's stack modalities. I'm like, please don't do it inside a hyperbaric chamber. Yeah, not in a chamber, no. Let's put hydrogen and red light in a hyperbaric chamber. I'm like, no, no, don't do that.

20:23Gary Brecka:Yeah, yeah, definitely. I do them separately or in sequence. Yeah. I love that. So as you increase the pressure, because, you know, what I do is I get my hyperbaric chamber four or five days a week, two atmospheres of pressure, I am going to stop using a nasal cannulas and either use a sealed rebreather like the HBO tech, because now you've made a case that makes perfect sense to me where oxygen is coming in, CO2 is going out, but it's not entering the chamber. It's just entering my lungs and then going out of the chamber. So you don't have this excess. Because, you know, I've always been under the auspice, incorrectly, that 100 % oxygen is combustible and flammable.

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21:09Gary Brecka:That's how it's medical gas. Interestingly enough, oxygen says right on it, if you read on the side of it, on the side of the bottle, colorless, odorless, non-flammable gas. Yeah. Oxygen's not flammable. It's an accelerant. It'll accelerate the flammability of anything that it gets in touch with, but it is non-flammable. So the oxygen itself won't burn. Okay. That's just an interesting tidbit of information. It's just providing the resources for something that is burning. It's the third part of the fire triangle, right? Right. So it's like heat, fuel, oxygen. If you don't have any of those three, you're not going to burn anything.

21:45When you have more oxygen, you're going to burn it more better. And higher and hotter.

21:49Gary Brecka:Yeah. Yeah, exactly. So if you're going to increase the oxygen saturation, other than using ambient compressed air, right? Ambient compressed air, probably the safest. Just fine. Just in a chamber that's not a dead chamber, that's circulating air, your two atmospheres, you're getting enough of a benefit if you're a longevity, not like I am, and you want to be doing hyperbarics for longevity, safe in up to two atmospheres, just using regular compressed gases. Yeah, regular compressed air. It's called scuba diving. Yeah, am I missing anything? Like, I feel like I'm cheating myself by not adding the oxygen.

22:28Gary Brecka:Am I gonna? No, it's what mechanism of action do you want at play? Hyper oxygenation is one of them. Add the oxygen in the safe way, right? You gotta do it safely. A sealed rebreather. Yeah, some sort of a rebreather, recirculator. We call it a bibs mask in a hyperbaric chamber, built-in breathing system. I just ate that bibs mask, man. You gotta have that kind of a thing. Yeah. for 90 minutes, I'm like, get this thing off my face. Yeah. You know? I don't know. I love that feeling because it gives me that. So when I breathe in, what do I want? I really want all the oxygen, right? I don't want the 15 % increase with the nasal cannula, right?

23:03I don't want the non-rebreather mask with this silly little bag doing this. And then where does all that exhaled oxygen go? Right into the hyperbaric chamber, which is only designed for air, not oxygen. So just, you know. Ah. Yeah. So you don't want your exhaled oxygen-filled gas touching any of the stuff in the chamber. I mean, it could be really dangerous, right? Right.

23:26Gary Brecka:So now, so you can use a chamber that's just circulating in the air, 1.5, two atmospheres, safe. Or use a rebreather if you want to increase the oxygen concentration. The ones that I, until this recent accident, heard that really exploded were the ones that had 100 % O2. there was a terrible story of the young kid i think he wasn't grounded and he wasn't grounded or something horrible and uh unfortunately when you're in this business and you see these things you can't unsee that video yeah that is a horrible nightmare right of we knew the answer right and most of these rules they're really written in blood right because oh why do we ground people because stupid things like that happen right when you don't ground people so it's like i didn't know oh you knew come on everybody knew so right yeah it's unfortunate but yeah so where do you see the future of uh biohacking slash recreational hyperbarics going um if you know this this adoption of hyperbarics seems to be going parabolic i think that there is a paucity of information out there.

24:40I would consider myself, you know, very much among the know.

24:46Gary Brecka:And I'm not even aware of some of these safety risks. This is why I'm excited to do this podcast, because just laying it out there hopefully will help a lot of people use these in the proper way. They're not toys. And you should be lauded for that. Trust me, because the people that are out there that are just kind of faking it till you make it, this is not the thing. So thank you, thank you, thank Thank you for going, hey, listen, I wanna learn a little bit on this. Yeah. Please and thank you. I really do. I mean, I wanna do it right. I mean, obviously I'd love to be in there with my red light mask and my - Right.

25:16Gary Brecka:My hydrogen running an NADIV, you know, on my PMF mask. Just kidding. But now we know that, listen, they're phenomenal tools. They are about to have some incredible science around longevity and aging, which I think is phenomenal. And not just around even the 13 indications. And if people use them safely, they can get long-term use and long-term benefit out of them. And I mean, that's the objective, right? It's the same with like red light therapy, with cold plunging, with all of these things. More is not better. Colder and longer is not better. Longer in a red light bed, higher milliwatts of irradiance.

26:00Gary Brecka:You know, there's therapeutic ranges that the body responds to and just get that dose and move on. You know, get your benefit and move on. And I, you know, I have that sort of inclination to that if some is good, more is better. Yeah. Right. So I want to resist that, especially when it comes to hyperbarics. You say more is better. And it's just a funny, funny joke. Cause I treat a bunch of military guys, right? And these guys come in and they're like, I can do five minutes. I can do seven minutes. I can do 12 minutes. I can do 50. These kids were up to 18 minutes in the ice bath. And I'm like, and we do 32 degrees, right?

26:35And I'm like, that's it. You're done. Nobody can go over five minutes.

26:39Gary Brecka:You're done. By the way, after that, the hormetic stress is over. Exactly. Right. And they're out, they're like. Yeah. And that's not good. You know, I mean, I saw a video on someone on Instagram a few months ago. I actually, I won't say who it was, but I messaged him privately and said, hey, you should take that down. but what he did was he took a snorkel went underwater in 35 degree water for 12 minutes and was just breathing through a snorkel and and then put it on social media I'm like man your brain is this far inside the surface of your skull yeah it's not good to bake it it's not good to fry it not good to bake it why do you think they wear hats inside the sauna for crying out loud come on I do the same thing so again the more is not not better so soft chamber is great hard chambers.

27:26It works. I mean, is it great? Is it going to cure your, you know, your aseptic bone necrosis? Nope. Soft chamber will not do that. But can it help you double your stem cells? Yes, we have the science behind that. Can it help you fix, heal better? Yeah, it can, you know, but we don't have a lot of detail in there. But yeah, you know, we got to get more science.

27:45Gary Brecka:One of the interesting things that I seem to be swaying towards too is how it, it's almost like a sleep mimetic because like during the deep phases of sleep when the glymphatic system is draining and you're getting you're eliminating waste from the brain cytokines histamines through these glymphatic channels that are that are opening during deep sleep similar physiology is going on with hyperbarics right with oxygen perfusion into tissues um i'm not saying it's a replacement yeah i know we're we're increasing the metabolism in the human body right so we're up upping the metabolism which makes you more tired which you know so like you wanted to go to the I don't know if it's this time, but, you know, talking about the underwater stay, right?

28:26When I stayed underwater, first of all, in the first 25 days, I lost 22 pounds. You lost 22 pounds. 22 pounds. So my medical team said - Metabolism was just - Because my metabolism was through the roof. My medical team said, that's it, you're done. Now you're up to, you know, 1.75 milligrams per kilogram body weight of protein. We got to double it. You cannot waste a weight of nothing. That's not going to work here, right? So, you know, that kind of stuff. but we talked about, you talk about deep and REM sleep. Normally a human sleeps between 30 and 33 % in deep and REM. Underwater, 60 to 66 % in deep and REM.

29:01Gary Brecka:Wow. Every single person that came down with an Apple Watch or an Aura Ring or a Fitbit or whatever the heck they had, they all correlated almost exactly, 50 to 60. So people would come stay with you. Yeah, I had a couple of people come and stay. How big was this thing? It wasn't as big as your studio. No way. No, no. Were you just going out of your mind after 100 days? No. It's like a bedroom. I will tell you. So it was maybe this wide and maybe 17 feet long worth of usable space. And then there was another side to it, exactly the same. And then a wet pod in between that you had to duck down in.

29:39I can get you pictures of it.

29:41Gary Brecka:Where people could come and duck and come in. Yeah, you come in and you're getting – it's your wet room, if you will. Okay. Where you shower, where you go to the bathroom. Yeah. That kind of stuff. Okay, so deep and REM phases of sleep, because obviously you're sleeping there. Double. Wow. So 70 million Americans alone have sleep issues, right? Hmm. And I doubled my deep and REM. So then what else happened, right? So this is how we don't know where the results, what happened and how the results got so good, right? Was it the sleep that healed me better, faster? was it the sleep that made me cognitively 13%, you know, 13 % better connectivity and a 5 % reduction in phase lag.

30:23Gary Brecka:I mean, holy mackerel. And were you doing like QEEGs? Yeah, I was doing EEGs every other day. Now, if you've not set up your own EEG, your new EEG, beautiful, brilliant. Thank you. Mine, it was like four hours of your life that you'll never get back. Sticking them on the head kind of thing. Yeah, yeah. Trying to get the thing to work, you know, I'm trying to push, it's crazy. Yeah. So, but you know, we did those and the quantifiable data is there. Now, EEGs are, they're okay, they're good, but you know, they're not perfect, right? You know, we're looking for the perfect telltale how to read inside the brain, but you know, it's the one thing that we don't even open up, you know?

31:03Gary Brecka:Yeah, but you had an increase in telomere length. You also had a 71 % decrease in cholesterol. Yeah, I had a pretty substantial decrease in cholesterol. So I don't remember if it was 71. If that was the solution for lipo little a, that would be great, right? So the cholesterol drop, everybody's like, well, it's because you weren't drinking alcohol and you drink alcohol and stuff. And I says, no, that's not true. They're like, what? I'm like, well, I'm a scientist, right? So like, you have to treat yourself how you do before, how you do during and how you do afterwards. So, you know, I had a drop.

31:34I'm just saying, I'm not saying alcohol.

31:35Gary Brecka:I wonder what the hell you do with all your time down. I'd be drinking Joe and I don't even drink. No, so it wasn't like that. We were really doing science. I mean, literally, while I was underwater, I'd wake up every morning at 5 o 'clock, and I used to drink coffee. Like I told you, I don't drink coffee anymore, but two, three cups of coffee would be my staple. And then, you know, protein in the morning, protein in the afternoon with salad, and then protein at dinner with something green vegetable of some sort, right? That's just the way I eat, right? So that's the way I eat on the surface. That's the way I eat underwater, right?

32:03Same stuff. Occasionally, I have a drink. Occasionally, I have a drink. I'm not saying that I did, but, you know, boss, don't yell at me.

32:11Gary Brecka:But you make it into the study design, but that's okay. Right. So, you know, but I would work then, you know, those are just the meals. I would work probably about six or eight hours, you know, doing my science, you know, blood, urine, saliva, electrocardiograms, electroencephalograms, pulmonary function tests. I mean, we did all this great science while we were down there and pretty much every day. And then, you know, I do three hours worth of interviews a day. And then, you know, towards the end, I was doing like CNN, ABC, CBS, Fox, right? So it was, oh my God. Once you had broken the Guinness Book of World Records record and you were still down there and then it became big news.

32:47I mean, Neil Cavuto came on board and told everybody in the world that my mother is a certain age. I was like, whoa, whoa, whoa. You said my mother's age. She's 49 as far as I'm concerned.

32:59Gary Brecka:That's great. And so when you got out and analyzed the data, what are you attributing this to? This prolonged hormetic stress? Because part of me says that when you provide too much oxygen or too little oxygen, the body becomes adaptive. Yep. Right? So did you adapt to the increased oxygen saturation? and then when you got back to sea level, feel like a tree slug? Absolutely, right? So I adapted. You know, I go in, I run really hot on the hemoglobin, right? So I'm like in the 15, 16 range, right? Okay, you're doing regular. When I came out of the water, oh yeah. Therapeutic phlebotomy. Yeah, okay.

33:44So when I came out of the water, I was in the 13s. Why? Because you're in an increased partial pressure of oxygen, thereby decreasing the need for hemoglobin so your body stops making it. So after a hundred days, I was a little sluggish. It was, but then when I came out, you know, a couple of weeks later, I checked blood and I was like, oh, right back up.

34:03Gary Brecka:Body came right back. Yeah, you know, you gotta be able to bounce. So can we live underwater long-term? Probably not, but can it be good for you? Can it be helpful? Look, hyper means more than, baric means pressure. That's it. You just increase the pressure, you get that benefit. How much or how little, that's what you gotta figure out, right? And it's not more is better, right? Like you said. And thank you for saying that because too many people just believe, oh, more is better. I'll just go to three. But these go to 11. I'm like, no. Right, right, right, right. Listen, there's what I share on this podcast and then there's what I share with my inner circle.

34:37Gary Brecka:If you've been following me for a while, you know how I hold nothing back here. But my VIP community, that's where the real magic happens. Picture this. You're struggling with energy crashes, brain fog, or just feeling like you're not operating at your peak and you don't know where to get real answers. But here's what really sets this apart. You're not just getting my insights. When I have incredible guests on the podcast, VIP members get to submit questions for a private podcast segment. So that world-renowned expert we just interviewed, you get exclusive access to their knowledge tailored to your specific situation.

35:09Gary Brecka:This section is under the private podcast section in the Ultimate Human Community. And speaking of exclusive, you're getting my personal protocols, the exact tools I use for water fasting, gut optimization, and morning routines that have taken me decades to perfect. This isn't theory. This is what works in the real world. The community launches challenges throughout the year where you get direct access to me and my network of experts. It's like having a personal health advisory board for less than$100 a month. Your health is your wealth, and this investment pays dividends for life. Join the VIP community at theultimatehuman.com forward slash VIP and step into your ultimate potential.

35:45Now let's get back to the Ultimate Human podcast.

35:47Gary Brecka:You know, when we talk about the research you're doing on TBI, which I want to come back to and touch in for a second, I want to go back to the XPRIZE because there are these machines now that create intermittent hypoxia. Yeah. So oxygen excess followed by oxygen deprivation. And there seems to be some real benefits. I've seen clinical outcomes where it's increasing VO2 max. And a lot of these are increasing VO2 max at rest. which I find really fascinating because VO2 max training is usually, you know, zone two, four by fours, all of the traditional mechanisms of increasing VO2 max. So this hormetic stress applied, you know, intermittently, oxygen excess, oxygen deprivation, seems to be having a very positive effect on the mitochondria.

36:42Gary Brecka:Maybe even increasing mitochondrial density or mitochondrial proliferation which to me would be the hallmark of age reversal. Right. Because that's what's happening. So if there was a really great way, I'm working with a company right now trying to figure out a good way to test mitochondrial stress and mitochondrial density right now, right? But this group is kind of coming through this at this point, but that stuff's in its infancy at this point, right? Yeah. So, but yeah, mitogenesis is one of the known mechanisms of action of hyperbaric oxygen, right? So, oh. New mitochondria. Yeah, I mean, I'm making it more better, right?

37:19This isn't rocket science. We just know the mechanism of action and we try and apply it, right? So, you know, when you're looking in the hypoxic state, oxygen deprivation, what we're doing is an altitude chamber. So you made the comment earlier about, you know, people in the long living zones being in the higher altitudes. Why? Better mitochondria. The mitochondria are working harder.

37:40Gary Brecka:I didn't even think about it. You know, this is going back a long time. You know, I was in the mortality. science space for years when I didn't really understand what mitochondria was. We just saw these observations. And, you know, increased life expectancy as you approximated the equator. Obviously relates to sunlight. Decreased life expectancy as you approximated the poles. And these are broad, you know, big data terms. but also that altitude correlated to extended lifespan. Yeah. And at the time, I just surmised that the oxygen intake was similar or matched more with the oxygen expiration, you know, so that the use of the gas was more even because we knew that an oxygen singlet, an oxidative stress can be oxygen and a single oxygen molecule trapped in this phospholipid bilayer can cause oxidative stress.

38:49Gary Brecka:So if you were somehow to match the intake of oxygen with the outflow of oxygen, seems like that would correlate to longevity. That was a very basic view. So just so you know. No, that's great. I mean, it's a decent first spot, right? Yeah, it was a first stab. But what you're saying is there is probably increased mitochondrial efficiency. Like these people are using oxygen more effectively. There's less of it. The body adapts probably by mitogenesis. Well, you know, when you increase your VO2, you are effectively, not effectively, you are using oxygen better, right? You're using it better. And that's why, so this is the thing I liked about Arizona State University and Team Healthspan and with the rules for the XPRIZE.

39:29The rules for the XPRIZE were not telomere length, right? Cause it's like, oh yeah, you're living longer. No, that's not it, right? Telomeres, yes, they will help you to live longer. You need those. However, comma, grip strength, right? VO2 max, right? We're gonna test all this data and that is required by the XPRIZE. So when they say health span, they really mean it, right? Because people go to the gym, when they're older, they're better. Muscle's gonna help you with everything. I don't care what your problem is. What you come across, you need more muscle. I don't know what it is, but you need muscle.

40:00So balance, walking, you fall and you break a hip, that's the curse, right? You need that balance.

40:07Gary Brecka:Yeah, I'm seeing in my parents right now. I've been very vocal about that. In fact, you just walked by my mom getting her QEEG. She's adorable. Transcranial red light. She's great. You know, I'm throwing the book at it. You know, I've got, you know, one of my parents' mind is great and body is failing and the other one body is great and mind is failing. And I think people find themselves in one of those two places. But, you know, I want to fight it incessantly because of what I do for a living, and I feel like I still have some control over this. And I'm a big believer in the trans-cranial red light and getting these cute EEGs to see where the active areas of the brain are.

40:47Gary Brecka:I will tell you lithium orotate, keto diet, controlling her glycemic profile, getting her moving, hyperbarics, have had a profound impact on this journey. Mood, stability, even the frailty aspect has improved in the last few months, being less frail, more robust, more conversational, easier to engage, better short-term recall. This is all anecdotal. Just an N of one with my mom. But hyperbarics has been a part of that journey. Huge, right? So my mother's 49, right? Been 49 for a minute or two, right? But my mother goes to the gym every morning. My mother drinks a gallon of water a day. My mother, you know, works out hard, you know, works hard, gets out there, does brain games, does hyperbarics, right?

41:42She's like, oh, my son's a hyperbaric guy, so I got to do hyperbarics, right? Wherever she goes, she just goes and does hyperbarics because she's a true believer. You know, even when she had some surgery, she had some desurgery and they were like, oh, wow, you're healing really well. Well, that's because I'm in hyperbarics. The guy's like, what?

41:57Gary Brecka:Yeah. Yeah. Yeah, so a pain threshold for them now too. And I've used it, clients of mine, for post-surgical recovery, for athletic performance. And in short bursts, it doesn't seem like you're creating kind of dependency, not 100 days underwater, but once a day, five days a week, two days off. But again, back to the XPRIZE, when you're now doing intermittent hypoxia in combination with pressure, you're not varying the pressure, you're only varying the oxygen, right? No, I'm actually pulling you to, I can go up to 29 ,000 feet in my hyperbaric, my hypobaric chamber, right? Okay. So when I evacuate the air, I'm giving you that true hormetic stress, just like if you were at altitude.

42:44Gary Brecka:Ah, so you're not just simulating oxygen saturation. Yeah, yeah, yeah. You're simulating barometric pressure, like - I'm changing the barometric pressure for sure. Like, so what we did is we, so look, you fly in airplanes, and this is the problem. You got to get things through institutional review boards and they move at a speed faster than glacial, right? And I'm just like trying to convince them that it's okay to go to 10 ,000 feet, to go to 8 ,000 feet. And they're like, you're going to kill all the old people because everybody has to be over 55 and less than 75, right? Okay, great. But everybody flies on an airplane and nobody checks your age before you fly on an airplane.

43:20And every cabin is pressurized to about 8 ,000 feet. Everybody goes to Colorado to go skiing once a year. but you know, 10 ,000 feet, 12 ,000 feet, nothing. And you hike, right? Like when I ski, I go out of bounds. I hike up to the top and then it's, right? Cause why? Cause it's fun, right? Yeah. But that's what we needed. And that's what we wanted to do. When we simulated those altitudes and then pushed that hormetic stressor and then dropped you into hyperbarics.

43:48Gary Brecka:This is, bam. And then we did ice bath and red light therapy and, you know, beamer mat. So we did a whole novel combination where we have the key. We have literally the click, right? Here it is. It's right here. This is exactly what you should do. Science proven, you know. Protocol. Yeah. And so it's, if I recall, it was 10 minutes of hypoxia followed by an hour of hyperoxia. Yes, sir. So oxygen deprivation initially. Yep. So that deprivation. so then you definitely run out of two atmospheres when you deprive them of oxygen. You were way... Yeah, you were at 8 ,000 to 10 ,000 feet, I think was the protocol.

44:32Gary Brecka:Okay, so 8 ,000 to 10 ,000 feet. Yeah. Then you bring them back down to what atmosphere? To two atmospheres. To two atmospheres, double the atmospheric pressure. Yep. And then increase the oxygen saturation. Exactly. Wow. Okay. Right? So 10 minutes deprived, 90 minutes off. If I had my druthers, it would be more like a half hour because I'm working with this girl who's on the... What are you using, like a pulse ox or something to make sure they're - Exactly. We pulse ox monitor them the entire time. We're watching them. You know, you have attendants that have to be there. They have to be trained.

45:02They have to know what they're doing, right? So when you're doing research - It's a controlled environment. Yeah, it's a very controlled environment, right? So we're checking people. If I had my druthers, I would take you to probably 12 ,000 feet, and I would have you work out inside the hypo-baric chamber. We don't work out inside a hyper-baric chamber because bad things can happen with heat and movement and bearings and stuff like that and batteries and blah, blah, blah, blah. Right. So everything's got to be right in the hyperbaric chamber. In the hypobaric chamber, all bets are off, right?

45:31Because there's no risk of fire because there's less oxygen. It's even less of a risk of fire on the surface. Not that you can smoke, but you know, it's not a thing. It wouldn't even, your cigarette wouldn't even light it, you know, 16 ,000 feet, you know? So, but yeah, I've never

45:47Gary Brecka:seen somebody smoking on Everest. Right. Yeah, exactly. And then if you're working out, what are you doing? Look, what we're trying to do at altitude is a lot of things, that hormetic stress response, the increasing the number of hemoglobin response. I mean, that is your mammalian reflex, right? When I pull oxygen from you, you make more hemoglobin, right? That makes perfect sense. Why do you think the Dallas Cowboys go to Colorado to train? right because they live at five six seven ten thousand feet and then they come down and they play because they're now full of red blood cells now they're ready to of course right that increases your blood doping it's legal blood doping thank you yeah it's legal blood doping and so the what you're seeing then and and to and i won't give any stats because maybe i shouldn't put those out there before the study is published um but this extension of health span and lifespan oh yeah that you're seeing, and we won't give it a number.

46:42Gary Brecka:This extension of health span and lifespan that you're seeing, do you believe that that is coming from the increased efficiency in the mitochondria, in mitogenesis, the production of new mitochondria? Are you making the existing ones more efficient? Are they producing more ATP? Like what mechanistically do you surmise is happening by depriving the body of oxygen? Because I'm really fascinated by this because I have a hyperbaric chamber. I have an HBO tech out in Colorado. Yeah. My house is at 10 ,500 feet. Oh, yeah. So I have a naturally hypoxic. I love it. Yeah. So I have a gym upstairs and working out there is very humbling because I do these high rock style workouts here with my son.

47:28Gary Brecka:And then I try to repeat the workout when I'm up there. And I'm like, good Lord. You're like, I can't breathe. I can't breathe. So I do a modified style of workout there. And then I go down and get in the hyperbaric and I do have a sealed mask, a recirculating mask. Let me tell you something. When I get out of that thing, I feel like I can solve some complex math equations. My PhD student and I just finished a paper on is hyperbaric oxygen a performance enhancing drug? Dude, I am telling you, another N of one, it is absolutely performance enhancing. When I get out of there, I am calm, focused, centered, clear, awake.

48:09Gary Brecka:i i actually want to challenge my like i actually feel like going back upstairs and working out again oh yeah you know um but i also feel like i can solve complex problems and i'm in that parasympathetic state oh yeah of almost zen like yeah yeah i love that i i love that too and it's hard to describe i get the same thing when i talk about this a lot too just putting on a rucksack one of those little ion i'm wearing one now this weighted vest i have a one that i use for working out and i have this little three and a half mile loop through the woods 10 500 feet come back i drop that thing on the deck and i'm like i feel like i found the messiah like yeah i feel amazing got millions of dollars of equipment in this in this unit nothing makes me feel better than that yeah um so what is happening by in in your opinion by flicking this switch between hypoxia and hyperoxia under pressure.

49:09Gary Brecka:Yeah. Because that's the key. What we think, and this is pure supposition, we don't know anything. We think we're increasing mitochondrial efficiency, right? I think we are. I don't even want to say we, because even the other researchers, you know, you see me, but there are 12 other researchers on this team and there are great scientific minds on this team, right? So not just me, I mean, not that I'm a scientific mind at all, but you know what I'm saying? Yeah. This team is well put together and perfect for what we needed. But all these hormetic stressors put together, all that stress that you want to put on your body when you go to the gym, when you go to the ice bath, when you go to the red light, all those stressors, man, all that stuff is actually good for you.

49:48So when you do that, you can make the mitochondria more efficient. And if you make the mitochondria more efficient, I liken it to a road, right? We want to pave the road. So we pave this much. Okay. And then I want a little bit more. Now I want a little bit more. I'm widening the road. I'm widening my ability to live because right now you're a human. You can live pretty much a hundred percent oxygen down to 16 % oxygen. I want that more. I want to be able to live in 14 % oxygen. Why? I want to be adaptive. I want to be able to go all the way up to 3.0, 300 % oxygen effectively. Right. I want to broaden that path.

50:22I want more muscle. I want to rip more fibers. I want to do this, you know, so it's, it's a, it's a wild thought, but you know, we're, we're still trying to find the science and correct the code on this there's a lot there yeah but i think that

50:35Gary Brecka:you know given the number of indications that it's approved for now yeah the relative safety um of it and using gas pressure hormetic stress these are all things that we have a lot of data on in terms of you know strengthening the body and improving performance and function and i think most people are after that cognitive benefit as much as they are the physical benefit, right? Athletic performance, great. But we all wanna have our faculties going late into life. Two things. So you said safety and I just wanna nickel on safety real quick. So we did 102 year exhaustive study of every single accident with any kind of oxygen involved.

51:23And we even included Apollo 1. That's how complete this was because it was an oxygen environment. It was a hypobaric environment, but oxygen. Less than 150 people have lost their lives in 100 years. Now, that's a horrible number, trust me. But 150 years or 100 years and 150 people, that is a very low number. That's way lower than aspirin. That's way lower than Tylenol. That's way lower than any of these other drugs, right? So it is not dangerous. if done correctly, right? Like when you start to combine hydrogen and putting your red light therapy in and doing all the stupid things that you know in the hyperbaric chamber, bad, bad juju, right?

52:03Take a class, learn, get your learn on and understand it, which like I said, you should be lauded because you're doing it.

52:09Gary Brecka:No, I really am. Practice what you preach. And I respect that I have such a large platform and I have to be authentic and intentional about the information I've been putting out there. And to the extent that it's been wrong, I want to correct it so that - 100%. People don't, you know, follow me and start doing the wrong thing because I'm glorifying how efficient I am in my hyperbaric. Right. Which, you know, I've done. And so that's why I'm so excited about this podcast is like set the record straight, put some guardrails in so people can safely use these hyperbarics at scale. You know, we're preparing to open 600 of these ultimate longevity centers.

52:51Gary Brecka:and we have hyperbarics and all of these ultimate longevity centers. I don't want hundreds of thousands of people to come in and be a human experiment in our locations. I want them to get a physiologic benefit at a very high level of efficacy and safety and not take the risk. If only you knew a guy to train all those people. You got a friend. Oh, he's asking for a job right on my podcast. This is great. And the other thing is, you talked about cognitive enhancement and especially cognitive enhancement in a declining age population. Yes. If only there was a paper that was just written on that by Shia Frati.

53:26That's exactly what it does. It's cognitive enhancement in a declining age population. When you say declining age population,

53:32Gary Brecka:what do you mean? We can't say elderly anymore, right? Because it's the wrong word, right? Okay. So yeah, as you're getting older, you know, he did the study, right? So we're increasing cognitive function. We're increasing, you know, the multitasking and the single tasking that's in that paper, we're talking, I want to say it was 17 and 35, don't quote me on the numbers, but a 17 or a 35 % increase in double tasking, multitasking and single task work. It's incredible. And this was in older ages. Yeah. In the older ages, in the 55 plus community, right? I hate that you call 55 plus older ages, first of all, because I'm 55, right?

54:11I'm 60 next year, man. Are you kidding me? Okay. Well, just talk about yourself. i hate to like you know when i started getting the aarp announcement i'm like

54:21Gary Brecka:screw you guys like you know i could get like a discount on my triple a i'm like i don't want the discount um yeah i hate it yeah but that's all right because i wear it man i'm like yeah i'm 60 come on let's go yeah you want to get on a mat let's roll and so so how are you using hyperbarics in your daily regimen sporadically right because sporadically and and you know a bit stochastically right? So I'm doing this, I'm doing this. Higher pressure, lower pressure, higher pressure, lower pressure. Because I personally believe that works. Like you, I have a Ferrari in my garage. Well, it's not a Ferrari.

54:55It happens to be a hyperbaric chamber. Same. I'm way more proud

54:58Gary Brecka:of my hyperbaric than a Ferrari. Exactly, right? So I do this on a regular because I believe, right? And I'm taking blood, urine, saliva. I'm doing all the mitochondrial function tests, working all this stuff, trying to figure all this out. There's a lot that goes into this, But look, why don't we have great research funded in hyperbarics? Who's the claimant for it? Who's going to make money on it? Yeah. It's the problem. It's the same thing with peptides and a lot of these other things. It does not make them invalid. It's naturally occurring. The trees make it. It's not like drug companies can make a million dollars on it.

55:33So there's no, you know, double, you know, there's no phase two clinical trial in hyperbaric oxygen therapy. My N at the University of South Florida was 420. And that's the largest one that's ever been done. The largest clinical trial in hyperbaric medicine history, 420.

55:50Gary Brecka:The TBI at USF. The TBI at USF, right? So that's it, 420. And you think about a phase 2D trial, that's like 40 or 50 ,000. No. And when we talk about traumatic brain injury, is this at the time of a concussive injury or is this traumatic brain injury from past traumatic brain injury and you're trying to recover function. Yeah. So I just wrote the book, Shattered to Strong, which is in editing right now, but you'll see that come out really soon. I'll give you a copy. But a concussion could be a traumatic brain injury, but all that involves, you know, it could be mild, it could be moderate, it could be severe, right?

56:27Right. And it depends on how many, what the frequency, chronic traumatic encephalopathy, all that ties in somewhere with repeated hits or just a single hit, right? You could get laid out with a single hit or have repeated really bad hits and you can get away with it, right? So there's a lot in there that we don't know, right? Even when we're doing the endpoint of the study and we went to the FDA, the FDA was like, oh, we don't like the way you solved the traumatic, a cured traumatic brain injury. I'm like, well, what do you call it? And they're like, no, no, no, we don't have a cured traumatic brain injury, but we're just gonna tell you that we don't like yours.

57:03Gary Brecka:Right. We don't like your endpoint, but we don't have an endpoint. So make a new endpoint. And I'm like, oh my God, it's so stupid. But you know, look, since papyrus, since the days of papyrus, 2 ,000 years before Christ, we had traumatic brain injury on the books. So we have had it on the books for 3 ,000, 4 ,000 years. Yeah, of course. I mean, men have been banging their heads and stuff. It's been written down. We don't have a cure. We don't have an endpoint. It's the only thing that I keep saying. We don't open it up. Look, if you look at the knee, I've done knee surgeries because I've ripped up my knee, but you've had this little plica inside the knee, a little bursa sac and a little tip on the end.

57:42You can't even see it on the images, right? And that's a one millimeter thing that's causing hate and discontent in your knee. And the orthopedic surgeon's like, wait till I get in there and I'll see. I'm like, what do you mean see? Well, we don't open the brain. We don't go look in the brain. We just treat it on the outside and go, ah, you'll be fine. What you need is a tincture of time. You want to piss me off? That's how, when I got my traumatic brain injury, that's what they told me. You just need a tincture of time. And I was like, yeah, I don't want a tincture of time.

58:12Gary Brecka:Yeah. How did you get a TBI? What is it? So I was driving my 1947 Chevy. Why? Because I dove 1 ,947 feet. So I bought a 1947 Chevy. Oh, that makes sense. Okay. There's actually a correlation there. I love it. So I got T-boned at nine o 'clock in the morning on September 7th of 21. T-boned. In an intersection, I had just come back from the gym, knocked out. Head hit the window? My head hit the window. You know, no airbags in that car, right? Bam, bam. Thank God it's made of steel because the other car was totaled. My car was totaled. I'm locked inside, shaved door handles. They can't get me out.

58:48I'm in the driver's seat. Wow. Somebody ripped the door off the hinges, thank God, throw me in the back of the ambulance. I wake up on the way to the hospital. They're like, hey, you okay? I'm like, who am I? who are you where am i what's going on look i'm in a pair of scrubs right i'm going to teach i'm like okay all right i get to the hospital and the guy's like oh yeah you're um you had a really bad hit eight millimeter hemorrhagic stroke prefrontal cortex left side right so wow bam hemorrhagic stroke bleeding yeah so they had me in the icu for two days uh looking you know fall risk the whole bit detailed in the book.

59:28It's a great story. And then, uh, five more days in the hospital. So seven days in the hospital total. And then they're like, tincture of time. That's all you need. And I'm like, that's what you got. I'm like, I'm a TBI researcher. How about hyperbaric oxygen? They're like, well, you really don't want to do that. That's, that's a lot of blah, blah, blah. And I'm like, you can't even spell hyperbaric oxygen. You're telling me not to do it. Come on, at least know what you're talking about. So.

59:52Gary Brecka:So you start, you did your N of one again. So I did my N of one. So here's the bad part, right? Like, so that was September 7th. I get out of the hospital September 14th. By the end of October, I'm ready to take my own life. I am literally suicidal because I'm just like, I can't, I couldn't think anymore. I couldn't reason. I couldn't function. I couldn't read, right? So it's like, oh my God, I'm bad. You couldn't interpret the words. Like you could see them, but you just couldn't reason what they meant. I had strabismus surgery when I was young, right? So part of that strabismus surgery, they pulled the eye in, right?

1:00:25So when they pull the eye in, I'd have a lazy eye, right? But they pulled it in and now it looks good or it's used to. Well, when you have this surgery, it's common to see one and a half images, but then that goes away. Your compensation, your compensatory reaction in your body compensates for that double vision and you phase it together and you see one. Well, when I got hit in the head, I lost all that compensatory behavior and I went right back to ground zero to the sixth grade right after the accident. And I'm looking at people and I'm like, there's your nose and there's your nose. So when I'm reading, I'm reading the first line here and the second line with this eye and the second line here and the third eye with this.

1:01:05And I'm like, I can't understand anything. And I couldn't even understand enough to figure out what was going on. So and then I wasn't sleeping common with traumatic brain injury sufferers. Right. It's like it was horrible. Right. So now I got despondent, but I needed to get there to get back, to get better. And that is the impetus of every single thing that I've done since then, right? The hyperbaric oxygen, the ice baths, the saunas, the neurofeedback therapy, the cognitive behavioral therapy, structural energetic therapy. All that stuff came from my traumatic brain injury because I needed to fix myself.

1:01:41The lifelong aging, anti-aging, healthspan cure thing, it all came exactly from my TBI. Thank God I had that. It was the best thing that ever happened to me.

1:01:51Gary Brecka:So I've been working out with my son lately, trying to keep up with him and his High Rocks competitive athletes, and I've been starting to use this Perfect Amino pre-workout. I really like it. It's got BH4 and improves nitric oxide output, but it actually seems to stay after the workout and not crash. There's no stimulants, so no caffeine, no Mao Wong, nothing that gives you that kind of amped feeling. You just feel like you're maybe better able to move during the workout, like you have better blood flow. So if you're in the market for a pre-workout, check out the Perfect Amino pre-workout. It's my favorite now.

1:02:19Gary Brecka:Now let's get back to the Ultimate Human Podcast. So let's talk about some non-brain benefits. A lot of people are touting healthier skin, youthful appearance to the skin,

1:02:34Gary Brecka:the oxygen being provided to these dermal, subdermal layers of the skin, actually improving the appearance of fine lines and wrinkles. Where do you fall in that? Yeah, I mean, look, it's collagen synthesis, right? Fibroblast proliferation collagen synthesis. We need that. It's not just the thing that the girls inject in their face. It's real stuff. Every cell in your body, most every cell in your body uses collagen, right? So it's the skeleton of everything. So you need it. So hyperbaric oxygen makes it. I mean, you know, science wins. Now, how it gets applied, yes, I have seen it. Yes, I've seen it reverse DNA damage.

1:03:10Yes, I've seen it. You have. But these are ends of one, two, five, 10, right? These are all small numbers, right? So preclinical sort of data. but you know we've also seen it reverse uh diabetes you know type 2 diabetes i've seen it reverse type 2 diabetes insulin sensitivity yeah wow and this is insane to think and you know i don't want to get killed or anything but like if we could do this we could stop people from taking drugs we could get people off of you know all these things but it takes work why why don't we have people going in it because you're a believer you go in it but how much does it take you?

1:03:4680 minutes a day?

1:03:47Gary Brecka:Yeah. 60 to 90 minutes. And you know, by the time you get there and you change and you unbox it and you drive there, like nobody can have it in their garage like you and I do. But you know, it's two hours out of your day. Who's got two hours in their day to go to a hyperbaric chamber for 40 times? Yeah. That's two months of your life. You're never getting back. Right. So not a lot of people have it. So patient compliance winds up being a real problem. So, but in the, in ambient air, compressed air, do you think it's safe for, because I'm thinking like if people could biostack, could they use a phone or a laptop under compressed air without?

1:04:23No, and the reason why is because those batteries are designed for, do you remember we were having problems on the planes with the batteries that were just blown, right? And they now even have a bag that they've invented to seal inside of it. And in the unlikely event, it has a problem on an airplane. The problem with that is you're sealed inside a hyperbaric chamber. So if you have a device in there and something goes wrong with it, you can't get out. And people are like, well, when you were underwater, Joe, you had a computer. I was like, yes. And if the computer caught on fire, I would take it and I'd throw it in the water.

1:04:57I had a hole in the bottom of the thing and I'd throw it in the water, right? Not like in the ocean. I'd throw it in the ocean to get rid of it, right? And it wouldn't be in the habitat anymore. How are you getting out? That's the problem. And then what happens when you increase temperature? you increase pressure you increase pressure now you're pressurizing your unit more you can't even unzip it or open the door i mean you know you can't get away from you know 15 pounds per square inch you can't open that door there's no way right right but you know you can't get it when it's increasing the pressure because you're increasing the temperature so yeah it's it's a no-go right if you have an issue just keep the vault like look the the new hyperbaric chambers that are coming out, your HPO tech, it's ASME PVHO approved.

1:05:44That's why I like them. They're going for FDA clearance right now. They're still in the process, whatever. But the ASME PVHO, I'm an engineer, right? It says engineers do this this way, right? We keep the, you know, the voltages down. We all, everything that goes in there is low. So you can have a type of a TV in there. You can have a monitor in there. You're allowed. It's just, it has to be done the right way. So if you're, so what's the one thing we haven't had on us right now? Our phones. My thumbs feel great. I don't have my damn phone on me.

1:06:16Gary Brecka:My thumbs feel great. Well, like how much do you take a break? So you take a break from your phone, I hope, right? In the hyperbaric chamber, right? You take a break from your phone. Guys, you need a break from your damn phone. Your phone is causing most of these problems. It's electromagnetic interferences. I mean, there's a whole conspiracy theory behind all that, right? But like, boy, get away from that damn thing. Relax, take it down a notch, breathe. When you say you come out and you're like, yeah, I feel great. You feel great. Cause you haven't had your phone. That's part of it. And we see the healing is much better when people have no external stimulation.

1:06:53Don't go in the chamber to watch movies. Don't go in the chamber to go in the chamber to have your alone time and keep that and cradle it and make it yours and be like, nobody's touching my hyperbaric oxygen time because it makes me feel better. And if it makes you feel better, keep doing it. So ditch the phone is my whole thing.

1:07:12Gary Brecka:Where do you see the future of hyperbarics going? Do you see it being common as a multivitamin in 10 years? Do you think that the research is advancing to a place where it's going to be a must-have? In someone's bio stack, obviously, price dependent, space dependent, time dependent. I get all that. But for that person that is on that longevity, biohacking, anti-aging journey, you see it as being one of those must-haves. A hundred percent. I do. I do. I see it. It's ubiquitous now. It has to be done the right way. Okay. The reason why we have such a great safety record in 102 years, less than 150 people gone.

1:08:01All right. We have a great safety record because we follow, build to this standard ASME PVHO stuff, right? And so we got to kind of get away from those, you know, hodgepodge ones, the ones that aren't being made right. And we'll continue to have a great safety record.

1:08:16Gary Brecka:And everybody just, you know, wants to buy it based on price. And I feel like if you're paying$25 ,000 for a hard show. Oh, you're going to negotiate price with me. I'm like, really? The guys that I'm talking to, I'm like, you are multi-multi-millionaire. and we're talking about the difference between$120 ,000 and$30 ,000, what is your life worth? To me, it's a no-brainer. Now, I get it. I'm not trying to be a big man on campus, but I get it. Price is an independent variable, is a thing. But your life is not worth taking that risk. So have it engineered the right way and do it the right way. But if you do that, I see it everywhere in every home for anti-aging, for whatever we're calling health span now, longevity.

1:09:00I think that it's truly, it's the one true force multiplier that everybody, like guys like Brian Johnson are saying, oh, it's the one true thing. And I mean, I talked to him.

1:09:09Gary Brecka:Myself too. Yeah. No, myself too. I mean, that's the most out for me. Guys are saying it's the right thing. I even got in an argument with Dave Asprey on stage over it. Really? Oh, yeah, yeah. About whether or not it was. No, you know, Dave did the whole intimidation thing, right? Like he stands up on stage and I'm like, bro, this ain't going to go the way you think it's going to go. So, but you know, in all lightheartedness, we had a good time afterwards. But, you know, it's the kind of thing that I believe is gonna show up everywhere because it moves the needle. Everything else is like, oh, put this magic cream on and it does, oh, come on, really?

1:09:44I see way too much of that garbage. I do too. So unfortunately, look, science wins over BS and the mechanisms of action work. And if you need collagen, this synthesizes collagen. That's all there is to it. I mean, let's not, you know.

1:09:59Gary Brecka:Overcomplicate it. Yeah, it works for problematic foot wounds. Does that mean it's gonna work for a bad arm wound? Probably. Is there data on it? No. Is there science behind it? Yes, right? So like, let's not throw the baby out with the bathwater. Let's not confuse, like your industry was, you know, your lifespan or how long you're gonna, when people are gonna die, right? So let's not confuse your health insurance with somebody that actually cares about your health and is gonna make you live longer, right? So this is the kind of thing that, look, it's gonna make you live longer. It's gonna increase your telomere length.

1:10:36It does that. It's gonna increase your cognitive function. It does that. We know it. The papers are there, right? So stop with the whole, oh yeah, I'm just gonna let insurance pay for me, you know?

1:10:47Gary Brecka:Yeah. No. I'm gonna go into a little bit of a touchy area. I saw a video by Dr. David Minkoff in Tampa, and he's somebody I hold in very, very high regard, by the way, at LifeWorks. I have personally seen him work miracles in oncology patients. And his whole approach to cancer is, don't just go after the villain, the cancer, also treat the host. You know, I use this analogy a lot. When a fish gets sick, First thing we do is clean the tank. His whole approach is keto diet, cleaning the tank, getting rid of heavy metals, mold, mycotoxins, parasites, viruses, all these things that are causing these low-grade inflammatory infections and also treating the cancer.

1:11:35And he uses these different stalking horse methods of, you know,

1:11:39Gary Brecka:driving blood sugar down with a keto diet, further down with insulin, introducing chemo in conjunction with glucose to increase the uptake. but he swears by hyperbarics in oncology patients. And I don't know if that's something where you want to tread, but - No, absolutely. Look, I am intrepid. Cancer is a metabolic shift, right? All cancer was at one time a healthy cell. It's not something that happens to us. Something happens within us. Something caused that cell's metabolism to shift. Maybe it was radiation. Maybe it was toxicity. Maybe it was genetics, number of things. So it's not this rogue DNA.

1:12:21Gary Brecka:It is metabolic shift in the cell from healthy metabolism to sick metabolism. And he has been out saying, listen, hyperbarics are part of our oncology. We treat our cancer patients with hyperbarics. Where do you fall on that? And what evidence have you seen, if any. Right. So John Feldmayer wrote a whole bunch of papers on this oncology thing, right? So we know that chemotherapeutic agents are made more toxic in a hyperbaric environment, which kind of stands to reason you increase VEGF, vasculi-endothelial growth factor. So you're actually feeding tumors, if you will, more, right? With VEGF, yeah.

1:13:08With VEGF, right? So with VEGF, but you're getting VEGF from hyperbaric oxygen therapy. It's one of the mechanisms of action. So, okay, if you're feeding that and you're doing chemo, you probably don't want to do drugs like cisplatinum or disulfiram because those are two absolutely known that they are made much worse in hyperbaric oxygen. So here was my thought, and Feldmeyer and company were like, you're an idiot, right? And I'm like, okay, I'm just a young researcher, right? So I said, instead of giving this much chemo and then letting them go off and do their thing, give them this much chemo, less, and then do hyperbaric oxygen therapy if chemotherapeutic agents are made more toxic.

1:13:50So I said, oh, that seems more better. And he's like, look, jokingly, he said, you're going to get yourself killed, man. Some big pharma guy is going to whack you. I'm like, no, come on, man, seriously. He's like, no, the problem is we don't know how much. It's made more toxic. So stay away from those. But I'll tell you this right now. What we're doing is I just finished a pre-paper proposal to a pediatric cancer foundation to talk about neuroblastoma and glioblastoma and taking beta-hydroxobutyrate to induce ketosis and remain in a ketotic state and then do hyperbaric oxygen on top of that without chemotherapy to shrink tumors.

1:14:30So there's some pre-work done by Prof and D 'Agostino on this, which is great stuff. And it looks good, especially with the beta-hydroxybutyrate in combination. Look - Ketone body. Yeah, ketone bodies, right? So oxygen is not helpful to cancer, right? It's hurtful to cancer, right? And then sugar, cancer loves sugar. So if we take away the sugar and we give it the oxygen, which it doesn't like, it's gonna start shriveling up, right? So we're going to see this proposal, but that's in rats or in mice, actually, technically. So we're going to do this proposal. And from what we're, the pre-clinical data says that we're going to shrink tumors.

1:15:11So can you help? But remember, this is like a traumatic brain injury. Cancer is kind of like, do you have testicular cancer? Do you have glioblastoma? Do you have, you know, myelo, whatever? You know, you could have any kind of cancer. So how do you treat cancer? 84 different ways. I mean, you know, but you can't go wrong by oxygenating and reducing the sugar. I mean, sugar's the devil in my opinion. I'm just saying, right? So get rid of the sugar in your life and up the oxygen. Like I keep saying in the book says, hyperbaric oxygen doesn't cure anything, but it helps your body help itself. And that's what we want, right?

1:15:49We want an organism that will fix itself better, right?

1:15:53Gary Brecka:Yeah. Yeah. I mean, you know, I talk about this theory of immunofatigue all the time where it is slow, progressive, overwhelming of the immune system. And, you know, as we become less capable of defending ourselves and also less capable of policing ourselves, you know, the immune system is watching the senescent cells and cellular autophagy and, you know, making sure a CTC, a circulating tumor cell doesn't slip by. It's like, well, that doesn't have the right metabolism. Let's kill that. You know, natural killer cells can kill other natural killer cells that are not performing, right? It's like having the SEAL Team 6 unit inside your house all the time, just making sure everything's running efficiently.

1:16:32Gary Brecka:And I think the immune system doesn't get enough credit for that because most people think of it as only protecting us, not also policing us. Right. And, you know, nothing can go wrong, in my opinion, by having a healthier, more efficient immune system. Yeah, 100%. This is why age is itself a disease. Yeah. All right. It truly is. I know, I think they just renamed it as a disease to be honest with you. Yeah, I think they just renamed age as a disease. You're young, come on. I thought I just came up with that on the podcast. So apparently not. But look, we have an overactive immune system. We really do.

1:17:11I mean, right now, what's the worst stress that you have? Like somebody didn't like my Facebook post or somebody said mean things to me in the car. I mean, our ancestors used to get tasted by saber-toothed tigers, for Christ's sake. Come on. Let's be real here. We don't have a lot of stresses in our life, right? So when we see something, we go like immediately overboard, right? All these killer cells, everything pops to their attention. Everybody starts like doing the thing that they're doing, right? And it's like, all right, all right, calm down. So you see systemic inflammatory response as a consequence of people with an overreactive immune system.

1:17:49So we just kind of want to quell that down a little bit.

1:17:52Gary Brecka:Yeah. Finally, I want to round out this X-Prize again, and then I've got a bunch of VIP questions for you. The VIP community knew you were coming on, and they've got a bunch of questions for you.

1:18:05Gary Brecka:So intermittent hypoxia and pressure is the sort of staple of this, but you are also using other therapies. Red light, ice, sauna. And red light, do you recall the nanometer wavelengths you're using? No. Okay. So you're using the red light therapy, sauna, ice bath. Are you going sauna to ice bath? No, not doing the back and forths, but we just did the one, right? So the one exposure. Look, we're looking for that 13 % increase in brown adipose tissue, the cold shock proteins. We're looking for all that stuff. Cold shock proteins, peripheral vasoconstriction, releasing norepinephrine, dopamine. You get it.

1:18:48Gary Brecka:Activation of brown fat, yeah. Oh, yeah. All those hormetic stresses, which are free when you expose yourself to cold water. I talk about it all the time. I'm like, you don't even need to spend, whatever, seven to 10 grand on a cold plunge. You can take a cold shower. Three to five minutes, you're done, right? Like, let's not overkill it, right? So sauna, 20 minutes, you know, something like that. 20 minutes, how are you stacking these modalities? Are they on alternate days? So hyperbaric is consistent five days on, right? Yeah, hyperbarics is five days on. Hypobarics is five days on. If I had the perfect world designed, right?

1:19:20Hype O-Barricks in the morning, hype-er Barricks in the afternoon. And between that time and that four or five hour time,

1:19:27Gary Brecka:go to the freaking gym, get your gym on, right? Then drink water, then do your red light, then do ice bath, then do... It's hard because I don't like to do the ice bath and the sauna before and after one another. I like to give that space. That's my personal opinion. I do the ice bath in the morning. I do sauna night before bed. I actually find it has a marked increase in my sleep score. I just got back from a crazy trip in Europe. I spoke in each day. I spoke in Utah. Then I went to New York. Then I went to London. Then I went to Cannes. Then I went back to London. Then I went to Maine. Then I went to Alabama.

1:20:08Gary Brecka:Then I went to Miami. You have a worse speaking schedule than me. It was brutal. but um i got back and i did uh red light i did about 25 minutes in the in in the sauna yeah took a cool shower didn't want to cool myself off too much took a cool shower went to bed and pegged the 97 percent sleep score and 97 recovery felt amazing the next day holy And I noticed that when I do sauna close to bedtime, dry off, allow myself to cool off in the shower. I don't do the ice bath or maybe I'll do one 15 to 30 seconds to bring my temperature down a little bit. I sleep so much better. It's like a secret sleep hack.

1:20:54A hundred percent. Just doing that. That's exactly what I would be winding up doing if the world was perfect. Now, granted, we know the world isn't perfect, right? And hyper barracks in the afternoon is the best from your cycles and everything. But when can I do it? I can only do it in the morning. That's the time that I have the person watching me because somebody always watches me in the hyper barrack chamber. I'm not a, you know, not do as I say, not as I do. No, that's not me. Right? So somebody's watching me and the only time they can watch me is in the morning. So I got to do it in the morning.

1:21:24Right? So you work out if it works out sort of thing.

1:21:27Gary Brecka:So do you have one of those HBO tech single units? I do. Yep. you're sitting in there and you're doing your somebody watches me and all I do is breathe everybody's like oh yeah you can watch TV in those and they have a tablet that you can I'm like I don't care I don't care A nothing with a battery goes inside my chamber at all ever that thing has got a less than 28 volts per ASME PVHO code but I don't do any of that TV as a matter of fact I don't even I stopped subscribing to cable because I don't even watch TV anyway so what the hell did I subscribe the cable for. So I don't subscribe to any of that stuff.

1:22:02I don't watch TV. I don't try not to look at my phone if I can possibly avoid it. Although, you know, you have to text and so forth,

1:22:09Gary Brecka:but, uh, you know, I mean, and you're using the, uh, yep. I'm using the bib system and I'm breathing in and out, right. Repeating as necessary. And I take those deep because look, everybody, when they do ice bath, they do the whole, ha, ha, ha, ha. Well, what's this? This is sympathetic nervous system. This is parasympathetic nervous system. So I want to relax. When I come out of that, I am so Zen-like. And that's the one thing, like being underwater for a hundred days, the one thing that I had to do was I had to look in the mirror every morning at myself. And there wasn't a lot of people visiting.

1:22:44I had a couple of visitors, but not a lot. So I did a lot of inward looking during that time. And I was like, dude, you better chill out. And you got some things you got to fix. I'm looking in the mirror at you. I don't like you very much. Let me change that crap. Right. So that's the key, man. So that's what you do in there. Make it your time. That's, you know, look, that's what we need. We need decompression time, right? Let me out.

1:23:08Gary Brecka:Let me off that phone. Maybe people, maybe people start to think of their hyperbaric time as that meditation time, that Zen time, that alone time, that quiet time. Please do your meditative breathing in there, whatever. I mean, you know, do your Wim Hof breaths. I don't care what you do, you know? Just like chill out. Yeah, yeah. I mean, and then maybe it's not such a detractor from your day, you know? My old approach was how can I be more efficient in there and bio stack things while I'm in the hyperbaric and you're really reframing my opinion on that. No, but if you wanna stack, stack by breathing, stack by meditating because you gotta meditate anyway, right?

1:23:50I mean, it's all a mindset thing. We know we got to meditate. You are a captive audience, bro. You're going nowhere. Yeah, no, you're really reframing how I think about it. And it's only you.

1:23:58Gary Brecka:Yeah. Now, nice thing. My wife loves it because no one can talk to her. She's all about the meditation. She's my people. Yeah, she's, you would love to say it. She's like, yeah, don't anybody talk to me and I'll just go in here by myself. Yeah. Dr. DeTree, this has been amazing. Joe, please, thank you. And I wind down all of my podcasts by asking my guests the same question. There's no right or wrong answer to this question. But what does it mean to you to be an ultimate human? Oh, wow. What does it mean to be an ultimate human? So I'm guessing for me, for Joe, it's living up to the potential that the good Lord gave me, right?

1:24:37So every morning I hit my knees, I thank him for the day and I say, take my hands, tell me what it is you want me to do. And I go off and do whatever it is that he kind of guides me towards, right? So maximizing that potential, I think I'm doing good by helping. I hope. I hope that's what I'm doing is helping people. So, you know, being a good human is a rare quantity today. So just kind of try and help as much as you can and be around long enough to help more people. Right. If I can live to 110, which is my goal year, I'm going for 110. So I'm barely halfway through my life right now.

1:25:14Gary Brecka:Well, let's see how your research comes. I mean, if your research comes out the way that it looks like it is, you take the XPRIZE, 110s in your mirror. Easy peasy, right? They're like, oh, they just approved resveratrol and rats and da-da-da-da-da. Now they're going to move it to humans. And I'm like, yeah, it's the wrong thing. I realize that's a hormetic stress, but that's not what we're looking for. Everybody's looking for the quick fix pill. Yeah, it's not going to be a resveratrol or NAD. You got to work. The ultimate human works, right? I see what you do here. you walk around this place you live it oh yeah you literally live it so you gotta live it and that's the way it's the only way thank you so much um i'm gonna follow your journey hopefully you are going to be the finalist for for the x-prize i'll have you back on excited about your research and where it's going thank you for shedding so much light on hyperbarics um this biohack that really doesn't have uh an authority in the space and and you and dr sauners i consider He was your student, authorities in the space.

1:26:14Gary Brecka:And I really appreciate you coming on and clarifying. Anytime, anytime, anything you need. Thank you so much. And until next time, guys, that's their science.

From the publisher

Dr. Joe Dituri, also known as Dr. Deep Sea, spent 100 straight days living underwater and walked away with lower cholesterol, longer telomeres, and twice the stem cells, so I had to get him on to break down what hyperbaric oxygen actually does. In this episode, we cover why a focused 20-day protocol might move your health-span more than any supplement stack, how his deep and REM sleep nearly doubled, and the safety rules almost no home-chamber owner knows. It genuinely shifted how I run my own chambers, and it'll shift how you think about oxygen, pressure, and aging, too. 

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Timestamps

00:00 - ​Intro of Show

01:52 - The 100-day underwater world record

02:13 - Cholesterol, stem cell, and telomere results

02:50 - From Navy diver to hyperbaric medicine

05:35 - The largest TBI study ever run

06:34 - The 13 mechanisms of action

08:58 - Why pressure and dose matter

11:03 - The $101 million X Prize

13:24 - The hyperoxic-hypoxic chamber

16:16 - Doubling stem cells in five days

24:06 - Why more is never better

26:18 - Deep and REM sleep underwater

32:18 - Intermittent hypoxia and mitochondria

42:54 - Altitude and legal blood doping

47:43 - A 100-year safety record

52:44 - His stroke and the road back

01:06:48 - Oxygen, sugar, and cancer research

01:14:10 - Stacking sauna, ice, and red light

01:16:57 - The sauna-before-bed sleep hack

01:20:30 - What it means to be an ultimate human

Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. 

Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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