295. Methylation Test & MTHFR Gene - Healf Experience Wellbeing Event 2026 in London

27:25But the amount of cofactors that are needed to target, direct that NAD, things like phosphatidylcholine, trimethylglycine, if you don't have those cofactors, you've gotten NAD through the gut and you've dropped it into the gut, it's crossed into the serum of the blood, and it stays right there until it meets a hydrogen ion and then it's reduced. So again, we should obey the laws of physiology and look for nutrient deficiencies before we assign pathology and disease.

28:02those are this is the ultimate human wellness formulation of supplements it took me two and a half years to formulate these I'm extraordinarily proud of these because if you spin any of these labels around what I have done is I have assumed that you can't convert anything I assume that you have the same series of gene breaks as people suffering from more significant ailments. And we already methylate these nutrients so that if your body can't produce them or absorb them, it is absorbed already for you. It enters directly into the methylation cycle. And this is the test that I've been preaching for 10 years that I think every single human being on the surface of the earth should do once in their lifetime.

28:48A genetic methylation test so that you can stop supplementing for the sake of supplementing and you can start supplementing for deficiency. That test, which you do once because the genes you're born with are the genes that you die with, you will never repeat this test. That test will tell you exactly what you are deficient in. And at no point in your lifetime will you be able to create those nutrients because if that genetic mutation exists, like it existed in your ancestor, your mother or your uncle or your mother's sister, which is where we get all of this genetic transgression of disease, it will continue to travel in your family, the characteristics will continue to travel in your family, the autoimmune, the deficiencies will continue to travel in your family, yet none of you have a genetic disease.

29:35You have a deficiency. As soon as you find out that raw material and put it back in the body, that's when magic happens. So I tried to get to the end of my presentation as fast as I could because my favorite part of being in front of audiences like this is to open the floor to questions. And I have, do we have microphones out there? Okay. So these lights are so bright. I'm having a, yes, ma 'am. Hi, it's a pleasure to be here. It's a pleasure to meet you too. You said that if we brought up some sort of ailment that we have, that you would be able to answer the question and hope this is the right time to bring that up.

30:17But I wondered specifically about fibroids and how that fits into what you've been seeing. Yeah, so fibroids, endometriosis, uterine fibroids, which usually has other connective tissue correlations related to it. These conditions, believe it or not, in the human body, it's very rare, if ever, that multiple systems fail at the same time. Usually what happens is one domino falls and causes an entire consequence of events. Like you will never convince me that somebody has more than one autoimmune disease. You will never convince me that people have multiple mental illnesses or multiple mood disorders.

30:58Usually one domino falls that causes everything. So in fibroids, what is the domino that falls? Believe it or not, uterine fibroids specifically. and when you image the uterus, and they usually do fibroidectomies for these, and you see these fibroids that are penetrating from the interior of the uterine wall, sometimes all the way through, multiple layers in the uterine wall, the first domino to fall is insulin resistance. You generally see a decade of elevated blood sugar prior to. We see this in neurodevelopmental disorders now. You know, there's an entire class of science that is calling Alzheimer's type 3 diabetes, insulin resistance in the brain.

31:41And the big fallacy is that people are losing their memory, but they're not losing their memory. They're losing access to their memory. So when you look at, especially in female hormone therapy, the consequences of insulin resistance and hormonal cycling, which causes not estrogen dominance because you are overproducing estrogen, but estrogen dominance because you are under-eliminating estrogen. the one that nobody tests for on female hormone therapy labs, which is why I recommend if you're a woman and you're going to do a hormone test, that you do something called a Dutch test. So if you have uterine fibroids, I would highly recommend that you get a Dutch test done because a Dutch test will actually look at the entire complement of hormones and it will look at all of the precursors.

32:25If you're deficient in pregnenolone, you have all these downstream consequences with cortisol, with aldosterone. You have your sleep-wake cycle is off. You sleep eight hours. You wake up exhausted. You have spells in the middle of the afternoon that they call crushing fatigue. And it doesn't show up on a blood test because a blood test is going to look at the level of your hormones, but not also how you are eliminating those hormones. I would absolutely do a Dutch test, a 24-hour urine test, if I was in that shape. Yes, sir. Right on. Yeah, yeah, yeah. You looking for somebody else. Yep, you're still looking for somebody else.

33:02right up here. He's like, me? Are you kidding me? You actually called on me? I did. You spoke a lot in the past about LDL cholesterol, which has been really fascinating. I have very, very high LDL, but I've also had very high lipoprotein A. And that's become quite, there's a lot of talk about that now. And there's, I think, new medication coming out for it, but constantly told it's genetic, can't be changed, you're born with it, your mother had it, your mother's, you know, all of that.

33:37Gary Brecka:Believe it or not, the lipo little a is a genetically inherited component. Yeah. Yeah. Yeah, you're screwed. Next question. No, I'm just kidding. Yeah, that is terrible for you. No, I'll answer your question. So, yes, lipo little a, lipoprotein B, those are concerning cholesterol markers. What I have consistently preached about and what the big data says, and so do meta-analyses, and we knew this 18 years ago because this is what the big data said, regardless of what randomized, peer-reviewed, published clinical trials showed, was that there was zero, and I will say this again clearly, zero correlation between elevated LDL cholesterol on its own and cardiovascular disease.

34:27We found that you had to have a corresponding increase in triglyceride. In fact, if you didn't, if you had low triglyceride, 75 milligrams per deciliter or less, and you had high LDL cholesterol, we would extend your life expectancy. Why? Because cholesterol, which is not a fuel source, it's a construction material. We make every cell wall, every cell membrane, every hormone in the human body. A large percentage of your brain is cholesterol. Cholesterol is how we make vitamin D3, sunlight and cholesterol, the only vitamin that a human being can make on her own, cholesterol is a necessary construction material.

34:59It does not just randomly and inadvertently jump out of the bloodstream and stick to the arterial wall. There needs to be damage to the endothelium in order for cholesterol to be called to that site.

35:10Gary Brecka:It is not the amount of LDL cholesterol that matters. It is the size of the cholesterol molecule. So if you remember from high school geometry, as the size of a sphere gets smaller, its surface area to volume ratio goes up. What does that mean? That means that if cholesterol was a tennis ball, the fuzzy yellow surface would be a triglyceride. It is transporting those around the blood. So if I actually had two basketballs sitting on a table, and those represented two basketballs of cholesterol, and they were covered in fat, both of them, and I raised the amount of triglyceride, Well, I keep cholesterol consistent.

35:52Those two basketballs become four softballs. I raise triglyceride more. They become eight baseballs. I keep raising triglyceride. They become 16 golf balls. I continue to raise triglyceride. They become 32 little BBs. Exact same amount of cholesterol in two basketballs or 32 BBs. Those 32 BBs are very dangerous. Very high markers for cardiovascular disease. The two basketballs, markers for longevity, not for cardiovascular disease. In fact, one of the interesting things that artificial intelligence is about to do that I believe is going to upend modern medicine in the next five years in a way that is going to be catastrophic for some pharmaceutical companies is you're going to see the big data surpass peer-reviewed clinical studies.

36:40Because now that we have early detection, big data, and artificial intelligence, we can take 700 trillion independent variables and create an actionable result. We are significantly better at doing artificial intelligence-guided clinical studies because of these 700 trillion independent variables that it can monitor than we are doing myopic, narrow clinical studies. In fact, to be patently honest, there is zero evidence, for example, that parachutes work. None. No one can make the claim that parachutes are effective, that they are safe, or that they should be used when you're jumping out of an airplane.

37:22There has never been a randomized placebo-controlled clinical trial. Who wants to be in the placebo group? Johnny, you're over here. Yeah. Give me your phone. You're not going to need that anymore. and you know Sarah you're over here you're going to jump out with this fancy backpack on and you're going to jump out with a hope and oh look at that there's so we have no proof that they work why do why would nobody jump out of an airplane without one because we have data and we have ignored data for half a century when the data was streaming in the opposite direction when we started hammering LDL cholesterol and you saw skyrocketing rates of neurodevelopmental disorders early onset Alzheimer's, early onset dementia, and cognitive decline in people who were holding cholesterol artificially low.

38:10So what makes it dangerous? Oxidation. What causes oxidation? Lots of things cause oxidation and free radical damage, but the main one is insulin resistance. I think the Bible should say blood sugar is the root of all evil, not the love of money. People are not dying because they love money. They are dying from blood sugar. That's a joke. All you Christians out there, I'm Christian too. Believe in Jesus. Calm down. But so lipo little a, which there is no pharmacological solution for today. There will be by the end of this year. There's some very promising drugs coming out towards the end of the year, which I am actually a fan of for lipo little a.

38:49But what I have found works very good to lower lipo little a are three things. the peptide thymocin alpha and a combination of bergamot O, which is a citrus field extract, and slow-release niacin. Make sure that you take the slow-release form of niacin, and it is one of the most effective ways, 15 to 30 % reduction in lipo little a, which there's no pharmacological solution for. So if I had elevated lipo A, which I do, I would be taking slow-release niacin, bergamot O, and consider the peptide thymocin alpha. I hope that answers your question. Yes, ma 'am. Yeah, right behind you, and then I'll get to you.

39:30Yeah. By the way, are you guys getting something out of this? Is this good? Are you awesome? I love you guys. I love London. I really do. I love your sense of humor. You guys have the wackiest sense of humor. Like, you can't just give somebody a compliment and let it go. You're like, hey, you know, you look pretty good for a fat guy. It's like, do you always have to do that? Like, you guys have the sickest sense of humor. I love you guys. Hi, Gary. Thank you so much for that. I would like an advice from you to the person who has high cortisol, but it leaves not stressful life. The person that has high cortisol and not a stressful life.

40:13So here's a theory in hormones that I want you to understand. We make hormones, cortisol is one of them, and these levels can be elevated because we are overproducing them, right? Estrogen dominance is very common in women that have high estrogen levels. Estrogen dominance is also common in women that have normal estrogen levels. Why? Because of the ratio of that hormone to another hormone. So in the human body, we are always, the body's it's called homeostasis the body is always trying to stay in this state of homeostasis so it's trying to maintain certain ratios so for example and i'm going to answer your question if a man has estrogen at 70 which is very high but his testosterone is 900 no problem if he has estrogen at 70 and his testosterone is 200 huge problem huge problem in hormones and in cortisol, the level is less important than the ratio.

41:19So the question is, what ratio is off driving cortisol high? So if any of you men that are on hormone therapy or testosterone therapy, you know that if you do an injection of testosterone and you do nothing else, your testosterone is going to skyrocket. What else is going to skyrocket? Estrogen. Your estrogen level is going to climb, which is very often why they pair hormone therapy, testosterone with aromatase inhibitors like anastrozole or extamestane or diandolomethane, DIM, to try to control that aromatization of testosterone. Again, I would go back to the gold standard test called the Dutch test.

41:55And in this test, you are going to see the entire cascade of hormones. And you are going, yes, you've done it. Thank you. You want to come up on stage and share it with us? No. No, I just went through menopause with my wife. We were in menopause together. Trust me. Trust me. It's a voice. I think it was harder on me than it was on her, but it's just my opinion. Because I would wake up in the morning, I would look at my wife, and I would go, babe, I am so sorry. She's like, for what? For anything. Whatever. She would literally turn around at the stove, and I would walk into the kitchen, and she'd go, I think you should leave the room.

42:36I'd go, why? She goes, I am furious with you. you've done nothing wrong, but I'm just telling you, if you don't leave the room, I'm going to snap my radish. And I go, thank you for the water. Right now, we go. So when you do this test, one of the things you're going to see is the other complement of hormones like pregnenolone. There are multiple estrogens, E1, E2, E3, and certain ones of those. Estrogen is a category, not an actual hormone. You have estradiol, estreon. So when you see that these get out of ratio, it causes other consequences. The thing I love about this Dutch test, and by the way, I sell in the Dutch test hard.

43:14I have no affiliation with the Dutch test. When you see these ratios, what I love about this test is it sets these dials. And so you see that your cortisol is extremely elevated. And you can see, is it overproduction or under elimination? And then you can target precisely that. But especially in women's hormone therapy, you want to be very cautious about treating your hormones off of a snapshot in time. A single blood test is a very dangerous way to prescribe hormones to women, especially if they are pre, peri, or menopausal. So I hope that helps. Yes, ma 'am. Yeah, now you. Who's got the microphone?

43:58Hi. So I had done a Dutch test and actually it showed that I metabolized the hormones very slowly or low. So all my hormones are low and then my cortisol kind of like wakes up in the morning, but straight away it goes down. And it showed that I can't metabolize it. Basically, it stays in my system. And so a quick one. And I also have Hashimoto's. So I know you mentioned it at the start and it's big for women. I love to talk about Hashimoto's. So, yeah, I think sugar is evil because I think I got it from the sugar. And it led to me having endometriosis as well. So, interestingly, if you look on the Dutch test, this is one of the most overlooked things on the entire Dutch test.

44:43Remember that methylation chart that I put up here? There is a gene mutation on the Dutch test called COMT. It stands for catecholomehyltransferase. So, I already know that you suffer. Can I speak openly to you? because I don't want to throw your dirt on the street. I already know that you have suffered with mild anxiety on and off your entire lifetime. And I know that it's hard for you to point to the specific trigger that causes it. Tell me if I'm wrong. Yes. Not so early on, but later on in life, yeah, massive anxiety. Just came recently, like two years ago. Yeah. And because of that mutation, you're also a ruminator and you have a tendency to carry things to the worst case scenario.

45:27especially if you think about them at night. So if you are considering a scenario, it will always end horribly if you're laying in bed and considering that scenario at night. It's high levels of fight-or-flight neurotransmitters. That same mutation is what eliminates estrogen. It sends it down what's called the E2 pathway. So now we're talking about not a hormone issue.

45:49Gary Brecka:We're actually back in this methylation chart. And we're back in this chart in the gene mutation, COMPT, C-O-M-T, catechol-o-methyltransferase. In your case, the anxiety, the ruminating thoughts, the poor sleep patterns, and if I looked at your sleep, your sleep duration would be normal, but your deep and REM sleep would be compromised. Especially deep sleep would be very narrow. See? Again, tell me if I'm wrong, because you're shaking your head. You can say? Yes. I think recently the sleep has been an issue. Yeah. So here is exactly the point that I'm making. I'm going to overgeneralize this.

46:24a mood issues, anxiety, you know, mental issue. You also have sleep and circadian dysrhythmia. If you, I'm going to actually give you that methylated multivitamin. So just go to the booth after this. I want you, I'm not kidding. I want you to take two of those in the morning and one at night, trimethylglycine and that sleep formula. And in 30 days, you let me know how you feel if it hasn't changed well you didn't pay for it so I can't give your money back so thanks 30 days if it doesn't change your life the heck with you yeah so I'm gonna give that to you it's gonna be life for you yes right there in the back in the middle yes pointing to yourself yeah with the sunglasses on I love how you guys are like so like for it like me yeah hi yeah Hi.

47:20You've mentioned neurodevelopmental disorders quite a few times. I was wondering what you would recommend or have to say about to someone like myself who has high-functioning autism or Asperger's syndrome. Has what? Asperger's syndrome. Oh, Asperger's, yeah. Because the only thing I've ever been helped with in any capacity for it was being put on psychiatric medication as a teenager that took five years to come off. Yeah. So I'm really glad you asked about Asperger's syndrome. So Asperger's syndrome is a flattening of mood. So what happens in Asperger's is the peaks and the valleys of mood disappear.

48:02So generally, Asperger's patients will have passion, elation, joy, arousal, libido. Those leave the room. But so do the lower tier emotions like vengeance, despair, jealousy, anger, like the really intense low tier emotions. And you're left with this mid tier, which we call mood numbness. This is not depression. It is mood numbness. It is an inability to transcend the normal categories of mood. Eventually, it leads to something called flat affect. But for decades, it stays, and you stay in this mood-numb state. The reason why we don't aggressively treat this is because you can live with it. It's not the thing that drives you to the emergency room or takes you to the urgent care.

48:49And so you become mood-numb. So the question is, how do we make mood in the human body? What is the main driver of mood? Serotonin. What's the main driver of behavior? Dopamine. And where do we make those neurotransmitters? We make them right here in the gut. And 90%, for example, of the serotonin in your body is right here. So if you don't have it here, you can't have it here. This is why depression can begin in your external environment, but it always continues in your internal environment. In fact, the serotonin hypothesis of depression used to define depression as an inadequate level of serotonin, yet we never had a single drug to raise serotonin.

49:25So the question is, how do you get the raw material to break out of that center section of mood?

49:32Gary Brecka:This has to do with going into the gut, and it has to do with fixing the gut so that we can turn the serotonin factory back on. In fact, if I go into this, here it is right here. We take an amino acid called tryptophan, and we methylate it into the neurotransmitter serotonin. And then that neurotransmitter goes up the vagus nerve and it populates the brain and you have mood and mental issues or normopathic mood. Same thing happens with tyrosine and phenylalanine. This is how we make dopamine. So could deficiencies in amino acids or breaks in the methylation cycle cause low serotonin, low dopamine, which creates aberrant relationships between other neurotransmitters and flattens your mood for an entire lifetime.

50:18These are not speech or neuromotor issues. These are not neuropathological disorders. The imaging in the brain is perfectly normal. If you've ever had your brain imaged, it is normal. It is the mood, mental, and behavioral characteristics. Mood, emotion, mental, and behavioral characteristics start with neurotransmitter production in the gut. and we never ever go to the factory that makes the resources that create the mood that we diagnose as this illness. So I think that genetic methylation test could change your life. If you haven't done it, I will give it to you. So come by the booth. I'm going to give you that test because I think it could be really life-changing for you.

51:05Yes, sir. You're right I love it. My team's like, he's just giving shit away up there. Get him off the stage. Hi, Gary. Can you hear me? Oh, yeah, sorry. I can hear you just fine. Fantastic. Always a pleasure to hear you speak. Thank you so much. My question is to anaphylaxis seems to be affecting an increasing number of people. Specifically, in my case, it's my seven-year-old son since he was a few months old. Severe allergies to dairy, eggs, nuts, fish, lentils, chickpeas. And it just seems really crazy to me that something, the human body so resilient, but like a drop of milk can basically kill someone.

51:40He has to have the EpiPen if he's accidentally ingested as much as a drop. And he also has asthma as well, so I don't know if that's linked. Secondly, just kind of in the anaphylaxis topic as well, random family members who've had no history of anything, apparently from like a pear or fruit have had to have been given an EpiPen. So I don't know if that's linked, but yeah, just around anaphylaxis, please. Yeah, so anaphylaxis caused by rapid, severe cytokine storms and histamine elevation. If you have a pen, you might want to write this down. I would look up and investigate something called MCAS, Mast Cell Activation Syndrome.

52:27Anaphylaxis is hyperactivity in the mast cell. So mast cells are cells that are all over your body. they're in your skin, they're in your blood vessels, they're throughout your arterial system. A mast cell is what secretes inflammatory cytokines and histamines. When these cells become hypersensitive and over-secrete inflammatory compounds, this is called mast cell activation syndrome. So now that we know it is a mast cell that is the villain, the question is, what is irritating the villain? And I will tell you, does someone have a top to a water bottle? I'll use this example here. I'll just use this.

53:09This is the most overlooked thing, in my opinion, in all of modern medicine. If this was a heavy metal, mercury, lead, arsenic, palladium, or it was a mycotoxin, fungi, or mold, or virus, or parasite. This does not hide outside of a cell like this. Let's say that this is a healthy cell. It hides like this. So the immune system and mast cells are hypervigilant, meaning they want to get to this perpetrator. In autoimmune, very often what happens is the immune system arrives at the wall of this cell to get to the perpetrator and it doesn't have permission to come inside. So how does the body gain permission to go inside the cell?

53:56It manufactures an antibody. Not to kill you or your friendly tissue to get to the villain. And we never think about subtracting from the body. Subtractive medicine. The first thing we do when a fish gets sick is we clean the tank. Why? Because you can look at the tank and you see it's all cloudy and mercury and you know that's why that fish is sick. When human beings get sick, we never assume that it could be a pathological invader that is causing the activation. So what I would implore you to do is heavy metal, mold, mycotoxin, and viral testing. Those four. I will say from this stage, there's an 85 % chance that this is the root of the issue.

54:40This is not an anaphylactic issue. This is an issue with your son walking around. Instead of his inflammatory cascade at a one or a two, he's walking around at a six or an eight. So a very small insert pushes him over the edge, right? Just like if I had two people on this stage and I said, okay, I'm going to push in on your back and you tell me how much pain you feel. And I push in on the first person's back with a pressure of two. And they're like, barely felt it. I push in on the second person's back and their pain level is 10 because they had a pinched nerve and started at an eight. same pressure, massively different results.

55:15So same insult, and your son meaning whatever it is, dairy, wheat, gluten, soy, the same insult, but a massively different result. It is where the mast cell, it is how inflamed and hyperactive the mast cell is. This is why very often that food sensitivity and food allergy testing is very inaccurate, because it doesn't delete your existing state of inflammation, right? So when we do most food allergies and food sensitivity tests, we take a membrane and we wash your blood down one side of the membrane.

55:49Gary Brecka:And on the other side of the membrane, we wash down all these allergens. We eat gluten, soy, dairy, blueberries, whatever. And what we're doing is we're measuring the amount of inflammation across this membrane. So if it's a 0 to a 4, it's mild. If it's a 4 to a 7, it's moderate. If it's a 7 to 10, it's severe. But what if you were starting at a six? Something shows up at a two. It shows up on the test as an eight. So you go get this allergy test done, and you are allergic to everything under the sun. And then you eliminate all of it, and nothing works. I mean, how many of you have had an experience like that?

56:29You start going down this food allergy, food sensitivity test, and you go on a diet or a food maps diet, and nothing seems to work. It's because the baseline sense of inflammation is high. And it is usually one of these five perpetrators, mold, mycotoxin, parasite, virus, heavy metal, with heavy metal being the most likely. So I hope that helps, yeah.

56:54Gary Brecka:Yes, ma 'am, and the red glasses. Dude, I love it, you guys are like clapping. I can do this all day, how much time do I have left? Oh, I'm two minutes over my time, so I'm at least gonna do one more question. All right, whoever just screamed in agony, you're next. She's gonna ask her question, and then the very loud British woman in the back. Because now I'm actually scared of you. So I'm gonna answer your question. I'll try to be quick. First of all, thank you so much for everything you do. I'm part of your VIP and I benefit so much. Oh, thank you. So thank you. I wanted to ask you about Vitiligo.

57:31I've been having it for nine years and it's been growing. But the last three months, I've been on a protocol that I made up myself, which combines several peptides and topical vitamin D, of course, a lot of supplements, including vitamin D, high doses, and red light therapy.

57:54Gary Brecka:Yes, good. It has improved so much. Yes. But I want to know from your point of view, which one of all of these that I've done has been the cause of this improvement? The greatest one for that improvement is red light therapy. And the reason for that is photobiomodulation, red light therapy, one of the hallmarks of red light therapy benefits is that when red light passes through the skin and then passes through the cell wall, it actually goes into the mitochondria. Certain wavelengths of light, 640, 820 to 840 and 940, they go into, they pass through the cell membrane of the mitochondria and it kicks out a gas called mitochondrial nitric oxide.

58:37When you kick this gas out from cytochrome C oxidase, oxygen docks. When oxygen enters this cycle called the Krebs cycle in the mitochondria, you have a 16 fold step up in cellular energy. So that's why they call like red light, like a battery charger, because it, you know, As we create ATP in the human body, and this cycle is turning around inside your cells called the Krebs cycle, every time it makes one revolution, it has two choices. It can make two ATP or it can make 36 ATP. Those are its two choices. 16 times more energy or 16 times less energy. What determines whether it's more or less powerful?

59:16The presence of oxygen. Where we go lost on modern medicine is we disobey the laws of physiology. So everything that enters the body doesn't make it to the mitochondria. Red light doesn't ask permission. It goes right through the cell wall, right through the mitochondrial wall, kicks this gas out, forces oxygen to dock, and kickstarts the mitochondria, which means it now has 16 times more energy. And what does that mean? Now, for the first time, maybe in your adult lifetime, the immune system can function in the dermal layer of the skin. and this is where you're getting the benefit from. Thank you.

59:54No question. Yeah. And the woman that screamed. I'm not scary, honestly. I'm just scared of you. And you would turn to that side. You didn't come to this side at all. And I was like, yeah. But thank you so much. First heard you on the Skinny Confidential many years ago. I also have a human biology background. I'm working research in the life sciences. Have figured out a lot of stuff for myself, reversed a lot of stuff for myself, but something that is not moving is my T3 conversion from T4 with Hashimoto's. My antibodies are lowering, but my T3 is just consistently low. My reverse T3 has been tested multiple times, and it's normal.

1:00:35And I can't figure out why my T3 is low. It definitely impacts body temperature and fat loss. So I don't know how to get it up. So just quick, you're probably already aware of this, but just to bring everybody up to speed, we're talking about low T3 from the thyroid. So the thyroid is right here in your neck. It produces two hormones, right? It produces T4 and it produces T3. These are the two hormones that are secreted by the thyroid. Only the little known fact about the thyroid is that it only produces 20 % of the T3 in your blood. 20%. So when your T3 is low, we call this hypothyroid. But when your T3 is low, there's an 80 % chance it's not the thyroid.

1:01:27Yet in 100 % of the cases, we put you on thyroid medication, levothyroxine, Synthroid, Armothyroid. So the question is, where does the other 80 % come from? And now I'm getting to your question. The other 80 % of this thyroid hormone T3 is converted from T4 into T3. The vast majority of this happens in the liver through a process called deiodinization. We take an iodine from the outer ring and remove that, and this deiodinization causes T4 to become T3. The majority of this happens in the liver. For you science nerds, some of it also happens in the periphery and the gut, but very little. So now we go into the liver and we say, what raw material is required for the liver to deiodonize thyroid hormone T4 and turn it into thyroid hormone T3?

1:02:23And it is these three nutrients, and they are the most commonly overlooked nutrients, and they are genetically inherited. Their deficiencies are genetically inherited.

1:02:32Gary Brecka:One is selenium. The second is selenocysteine. and the third is selenomethionine. And I could take you right into this chart and show you exactly how those are methylated. So if you are deficient in the complex of B vitamins, you're deficient in methylfolate, you're deficient in trimethylglycine, TMG, then your body cannot take selenium, which comes into the body. You could take a selenium supplement, convert it to selenomethionine, convert that to selenocysteine, which is the catalyst for that transaction. In the absence of those nutrients, the body, the liver cannot deiodonize T4 into T3. Your T3 stays low, you get autoimmune antibodies, and you have a lifetime of hypothyroid.

1:03:22I would bet my entire career that it is one of those three nutrients.

1:03:27Gary Brecka:And again, that gene test could potentially change your life, at least change your thyroid. I supplement selenium, but I need to get the specific, make sure that it has all three forms. Yes. That's where we go wrong, right? Because selenium is where it starts. Selenium gets converted to selenomethionine. Selenomethionine becomes selenocysteine, and selenocysteine is what catalyzes that transaction. So if you put this raw material in, remember I said nothing enters the body and is used in the form that you put it in? Selenium enters the human body. It's not used as selenium. It's converted to selenomethionine and then to selenocysteine.

1:04:02It's the selenocysteine that deiodonizes T4 into T3. In the absence of that, you can't make that conversion and you have hypothyroid. The second thing I would say, and this goes with anyone that has autoimmune thyroid, the 85 % of the time when you're diagnosed with autoimmune thyroid, Hashimoto's, you are told it's random or even worse that it runs in your family. We've already spelled that myth. So the immune system doesn't randomly attack the thyroid. The thyroid has an affinity for heavy metals. It is literally like a magnet for heavy metals.

1:04:34Gary Brecka:So mercury, lead, palladium, cadmium, they get embedded in the thyroid and the immune system goes after the metal, not the tissue. Right. So I would really encourage you to get heavy metal toxicity testing. Probably the best one is a urine test called a vibrant wellness, or you can get a provoked heavy metal test, which is where you do chelation and then collect urine for the next six hours. And you'll see, I would be absolutely shocked if you had autoimmune thyroid and didn't have heavy metals. Look, full stop. Thank you. You're welcome. Okay. Can we do one more question? Awesome. I love it. I love this.

1:05:16Okay. Yes, ma 'am. And the orange. Warsaw.

1:05:25How you doing? Hello, Gary. Thank you very much for the opportunity to ask this question. is regarding IBS. I wanted to ask if you think that IBS is correlated with a nutrition deficiency, or do you think it's a nervous system kind of influence? And also, how do you approach in general to improve this? Yeah, so IBS, irritable bowel syndrome, which please don't take this the wrong way. I think that is such a nonsensical diagnosis, right? IBS is a name for a category of symptoms. If you have gas, bloating, diarrhea, constipation, irritability, and cramping, you have irritable bowel syndrome. So all I did, thank you very much, was just take all of those symptoms and give it a name.

1:06:14Right? So now you have a name to call all of your symptoms, so you just don't have to describe them one at a time. So the question is, what is causing this condition? By the time most people make it to me, they have already done food allergy and food sensitivity testing. Most have done a GI map, so they have checked their gut microbiome. If you haven't, a good GI map stool test would be an excellent place to start. What they have overlooked, in my opinion, is the most overlooked thing in all of bariatric medicine. That is the pace of the gut, right? Because the speed of the conveyor belt is more important than the contents.

1:06:51Your gut is 30 feet long. It's a 30-foot-long conveyor belt. We drop contents on it at one end. As they leave the stomach, they exit the rectum 30 feet later. The pace, the timing of that is critically important. And the reason is because it takes a certain amount of time to pass contents from one pH environment to another. So think of it like a factory as an assembly line. You run it too fast, diarrhea, run it too slow, constipation. If it pauses, bloating, cramping, diverticulitis, ulcerative colitis, right? And if they pause for too long and erode the single cell layer of the luminal wall of the intestine.

1:07:25Now you have something called leaky gut that calls the immune system. And the immune system spends too much time there. It manufactures an antibody to the colon. Now you have Crohn's disease. So, but at the root, the first domino to fall was poor pacing in the gut, was the absolute poor pace of the gut. If you have irritable bowel syndromes, the one thing I know you also have is dysregularity in bowel movements, right? They're never consistent. Off for two days, three times in one day. Then every 24 hours, then skips two days. Then normal, then skips three days, right? There is an exact indication that it is the pace of the gut.

1:08:05And I mean, I hate to keep bringing it back to that gene test, but that gene test could materially change your life. Because if you have the gene mutation, MTHFR, MTR, MTRR, you are going to find that your intestinal motility is off. You can supplement to fix the motility. You fix the motility, then you fix the problem. Okay. Guys, awesome. I'll be around. Thank you so much. Thank you so much. Amazing, amazing, amazing. I love you guys.