In short
Building muscle after 50 by targeting anabolic resistance with the right protein/leucine strategy and evidence-based supplementation; also covers creatine dosing/forms, supplement “five pillars,” training variety for longevity, and emerging myostatin/follistatin gene therapy.
Guest backgrounds
Dr. Jim Stoppani (PhD in exercise physiology; Yale-trained researcher; biochemistry background). Former writer/editor at Weider Publications (Muscle & Fitness, Shape, Men’s Fitness, Flex). Built training/nutrition programs for The Rock, Dr. Dre, and LL Cool J. Known for criticizing under-dosed “buzzword” supplements and proprietary blends.
Key claims
- Supplement effectiveness depends on clinical dose, form, timing, and synergy—not just ingredient names.
- Creatine is an energy molecule that rapidly supports ATP; most people need ~5 g/day (with food).
- Creatine monohydrate has more data but ~20–30% can’t tolerate 5 g; ~50–60% can’t tolerate 10 g (GI issues). Creatine HCl dissolves faster and may reduce GI problems.
- After 50, anabolic resistance reduces muscle protein synthesis; leucine is the trigger (via mTOR). Take branched-chain amino acids ~30 minutes before meals to reduce leucine sequestration.
- Post-workout “anabolic window” is overplayed for most people; eating within ~1 hour is fine.
Notable examples
- Sleep-deprived cognition: very high creatine dose (25–30 g) mitigated cognitive hit.
- Myostatin inhibitors: egg-yolk follistatin reduced myostatin ~40% in middle-aged men, but exercise + creatine already lowers myostatin ~30–40%, limiting added effect; gene therapy may be different.
Written by AI. May contain mistakes. Listen to the episode to check what was said.
Chapters
Tap a time to open that second in VOUnderstanding Supplement Efficacy
0:00 to 1:23
Learn about the importance of proper dosages in supplements and their effects.
“So many companies were taking advantage of consumers who just read creatine, beta alanine, that don't understand you need a certain dose of each one of those ingredients for them to be effective.”
Diving into Creatine
2:17 to 4:24
Explore the significance of creatine in both muscle building and cognitive function.
“Welcome back to the Ultimate Human Podcast.”
Creatine: The Energy Molecule
4:24 to 5:38
Understand how creatine functions as an energy source and its importance in the body.
“I think it felt, you know, when I was in like college, it was like the bodybuilding.”
Cognitive Benefits of Creatine
5:38 to 7:22
Discuss the cognitive benefits of creatine and its role in mitigating sleep deprivation effects.
“And so to contract muscle, to run, we need ATP to fuel all that, every process in the body.”
Comparing Creatine Forms
7:22 to 9:39
Learn about the differences between creatine monohydrate and hydrochloride.
“and see that all the results kind of come out the same, right?”
Tolerance and Bioavailability of Creatine
9:39 to 11:15
Discussion on the tolerance levels of different creatine forms among individuals.
“And you're attaching something to it, okay?”
Introduction to Energy Production
14:00 to 14:58
Learn how nerve cells can work more efficiently, similar to muscles.
“And at the end of the day, it's providing energy to the nerve cells.”
Neuroinflammatory Issues and Creatine
15:04 to 15:40
Explore the link between neuroinflammatory issues and the potential benefits of creatine.
“Now let's get back to the Ultimate Human Podcast.”
From Academia to Bodybuilding Publications
15:40 to 17:06
Discover Jim's transition from academia to the practical world of bodybuilding media.
“So would you make the blanket statement that at a certain age, everybody should be on a certain dosage of creatine or not quite yet?”
The Role of Bodybuilders in Health Knowledge
17:06 to 18:51
Understand how bodybuilders contributed to early discussions on supplementation and health.
“which, you know, Los Angeles was the mecca of bodybuilding at the time.”
Show all 26 chapters
Frustration with Supplement Transparency
18:51 to 20:19
Learn about the challenges of finding quality supplements and the issues with proprietary blends.
“Because here you are as an editor for these magazines trying to provide quality information to the reader.”
The Journey to Creating a Supplement Line
20:19 to 22:48
Hear about the motivation and process behind formulating a supplement line.
“You know, I feel the same thing going on in the biohacking space.”
Misleading Claims in the Equipment Industry
22:48 to 24:06
Discuss the pitfalls of consumer perception regarding fitness equipment effectiveness.
“And I think you find this, you know, not just in the supplement industry, but also in like, you know, equipment industry.”
Five Pillars of Supplementation
24:06 to 26:33
Learn about the essential criteria for selecting effective supplements.
“I mean, how does a consumer, in other words, pick something up off the shelf, you know, a supplement, and kind of ensure that they're getting what they're expecting to get?”
Building Muscle After 50: Key Strategies
26:33 to 28:01
Discover the importance of protein and leucine for maintaining muscle in older adults.
“So if you have creatine with a meal, right, protein and carbohydrates, you're going to have an increase in insulin that's going to help to drive that creatine to the muscle.”
Reflections on Risk in Aging
28:01 to 28:41
The conversation explores the perception of risk and injury as one ages.
“doesn't think he can be killed by a bullet neither one of my sons um just because they haven't been really hurt yet.”
Understanding Anabolic Resistance
28:42 to 30:23
Discussion on the importance of protein and leucine for muscle building after 50.
“But the secret to building muscle after 50 is protein and leucine.”
Branch Chain Amino Acids and Their Use
30:24 to 32:55
Insights on the role of BCAAs and leucine timing for optimal protein synthesis.
“Okay, so that's where that ratio comes from.”
Whole Foods vs. Supplements for Protein
33:39 to 35:35
A detailed comparison of protein intake from whole foods versus supplements.
“So are you still a big proponent of get the majority of your protein from whole foods?”
Resistance Training for Middle-Aged Lifters
35:36 to 41:34
Discussion on effective resistance training strategies for older adults.
“And then I'm going to have my whole food.”
Gene Therapies and Muscle Growth
41:35 to 42:01
Exploration of gene regulation research related to muscle growth and therapies.
“Another, I think, really hot area is gene regulation research.”
Exploring Myostatin and Muscle Growth
42:01 to 48:16
Discussion on myostatin, gene therapies, and their implications for muscle growth.
“Yeah, so taking the governor off of muscle growth, where do you fall in some of these gene therapies?”
Middle-Aged Fitness: Strategies and Nutrition
48:55 to 56:00
Insights on workout strategies for middle-aged individuals and post-workout nutrition.
“Now let's get back to the Ultimate Human podcast.”
Must-Have Supplements for Strength Training
56:00 to 58:39
Learn about the essential supplements for those over 50 focused on strength training.
“But it also is a bit like caffeine, where it gives you a little bit of a pick-me-up, a slight one.”
NAD and Its Impact on Aging
58:40 to 59:39
Discover the role of NAD and its supplements in enhancing longevity and health.
“Or do you have an opinion on NAD, NAD plus?”
Defining Ultimate Humanity
59:40 to 1:00:46
Explore what it means to be the ultimate human in terms of performance and kindness.
“for nutrients like that are critical because a lot of those are just denatured, first-class metabolism.”
Transcript
Automatic transcript. May contain errors.0:00So many companies were taking advantage of consumers who just read creatine, beta alanine, that don't understand you need a certain dose of each one of those ingredients for them to be effective.
0:10Gary Brecka:Supplement manufacturers just throwing things on the label, like creatine, but putting it in dosages that someone that didn't have the background that you had saw it on a label, they're like, okay, this must be a good supplement. But what's the dose? Every ingredient is only going to be effective at a certain dose. Your background in the supplement industry, your background as a writer, an educator, and having a biochemistry background means that you can take the practical application, muscle building, fitness, exercise, and bring it all the way down to the cellular level. As you're aging, what is important?
0:41Mobility, maintaining muscle, metabolic health. I would say for the middle-aged and older, you want a more well-balanced fitness routine. In fact, there's research suggesting that those who work out with more variety have more longevity.
0:58Gary Brecka:What is the secret to maintaining a muscular physique and not getting injured when you get into your 50s? The secret to building muscle after 50 is...
1:22Gary Brecka:Hey guys, welcome back to the Ultimate Human Podcast. I'm your host, human biologist Gary Brecca, and today we're settling the score on one of the most debated topics in health and fitness, supplementation. My guest is Dr. Jim Stepani, a PhD in exercise physiology, Yale-trained researcher, and the man who's built training and nutrition programs for The Rock, Dr. Dre, and LL Cool J. Jim is going to break down creatine and why up to 30 % of people can't even tolerate the standard dose and what to take instead. We're going to dive into protein, leucine, and exactly what happens to your body's ability to build muscle after 50, a phenomenon called anabolic resistance, and what you can do about it starting now, no matter what your age.
2:05Gary Brecka:We'll even get into the cutting-edge myostatin gene therapy and the future of muscle growth. Whether you lift or you just want to still be strong and independent decades from now, this episode is required listening. Let's get into it. Hey, guys. Welcome back to the Ultimate Human Podcast. I'm your host, human biologist, Gary Brecca, where we go down the road of everything, anti-aging, biohacking, longevity, and everything in between. And today's guest is actually going to answer a lot of questions that are all over the media right now. We're going to settle the score on supplementation, creatine, cognitive function, what you need to do now, even if you're in your 20s, to reach older age and still be healthy, strong, and thriving.
2:46Gary Brecka:And before the podcast even started, we started a mini podcast in the kitchen. I'll share that with you guys in just a moment. But Dr. Stepani, Jim Stepani, welcome to the Ultimate Human Podcast. Thank you, Gary. Pleasure to be here. Yeah, I'm really excited to have you on because you see people that are walking the walk and talking the talk. And then you see people that really have their arms wrapped around the science. And I think you're that rare breed hybrid that has both. Thanks. I think I would say the same. Yeah, that's my passions of the science, but also the real world application of it.
3:23Gary Brecka:Yeah. I mean, clearly it's working. For the record, he is substantially older than I am. He's two years older than I am. I want to get that out of the way early when he was like, I graduated high school in 1986. I was like, yes, I graduated in 1988. So I was a sophomore. You were a senior. You're so far ahead of me. but you can live your care for younger years through my eyes. But I feel like if I had a sleeve, I might look more jacked. But it appears that those are real muscles and not tattooed. But I'm so excited for this podcast because your background in the supplement industry, your background as a writer, an educator, obviously getting your doctorate and having a biochemistry background means that you can take the practical application of muscle building, fitness, exercise, and bring it all the way down to the cellular level.
4:17Right.
4:17Gary Brecka:So I would love to start with what I think is the hottest topic in supplementation right now, which is creatine. Of course. And creatine's been around forever. Forever. I think it felt, you know, when I was in like college, it was like the bodybuilding. Yeah, mid-90s is when it really took off. Yeah, it was all of the bodybuilding rage, I assume, because it helped to retain some water in the muscle. But now it's starting to emerge with cognitive benefits. Yes. And that's why we're hearing people talk about it. And that's why we're hearing people talk about it. So could you, first of all, what is creatine?
4:53Gary Brecka:How does the body make it? And then let's go down this debate between monohydrate and hydrochloride. Why is one better than the other? Are they about the same? I know we have more data on one than the other. But, you know, I have my parents on it now for cognitive function. Of course. And they're in their 80s. I recommend everyone literally should supplement with creatine. So creatine is a what in the human body? It's an energy molecule. You know, everybody thinks it's this muscle-building supplement. And we make it in our lives, right? Yeah, and it's one of the most critical energy molecules in the body.
5:30And the reason why is because it provides what's known as a high-energy phosphate. And if you know what ATP is, right, or adenosine triphosphate, a little maybe a little too technical. but that's our energy currency, right? And so to contract muscle, to run, we need ATP to fuel all that, every process in the body. Even to think. And creatine helps to make ATP and it helps to make it very quickly, which is why it's so important for like when you're lifting weights.
5:58Gary Brecka:Do we naturally, like a lot of things in aging, does our capacity to produce creatine decline over age? Possibly. Or does the need go up? It's not really one of those, you know, even though we do make it, it's not like, say, DHEA, where as we get older, it starts decreasing, right? But what we do know is that to really maximize the benefits it can provide, what we get in our daily diet and what we make is not enough. Where would we get creatine from in our diet? So you get it from meats, like animal, beef, fish. I assume you're a meat eater. I am. Great. I am too.
6:44Gary Brecka:It's a complete protein. Sorry, vegans. It's a complete protein. Mom, it's a complete protein. I worry about my leucine intake. Yeah. So why is it now crossing the boundaries into being no longer just a bodybuilding supplement? I mean, where does the data fall on cognitive function, neuroinflammatory conditions? Yeah, there's a lot of interesting data on creatine, not for muscle building. And one of the most discussed is the brain benefits. And so there's research, you know, single studies, meta-analysis studies, where they take a bunch of studies and sort of look at them all and see that all the results kind of come out the same, right?
7:28That's what it meant. It's a study of the studies. And what the studies of the studies show is that taking creatine can provide some cognitive benefit, improving memory, right, recall. And there was a recent study showing that if you're sleep-deprived, a high, a large dose, and again, this was almost 30 grams of creatine, 25 to 30 grams.
7:53Gary Brecka:In one shot or over an entire day? In one shot. Decreased the sort of cognitive hit that you get from sleep deprivation. So mitigated the effects of sleep deprivation. And is it something? But now, what we know about creatine in muscle is a lot. What we know about creatine in the brain is very little. It's early. But, so we know it takes about three to five grams of creatine per day to provide benefits to the muscle. For the brain, we may require a little more, maybe closer to 10 grams, because it's harder to get past that, you know, blood-brain barrier. Right. And what about the forms of creatine?
8:39Gary Brecka:You know, there's a big debate of monohydrate versus hydrochloride. of chloride, my understanding is that the HCL version is a little more water soluble, but the monohydrate is where there's a lot more data. Yeah. So let's talk about the form. So if you thought about creatine in a lab somewhere, let's say a scientist studying creatine and he's got a jar of it, right, in his lab, right, what would that form be? It would be creatine monohydrate. It's just its default form. Okay. Okay. And so the very first study was done using creatine monohydrate. And so when scientists want to replicate something to see if, oh, that study showed results, will it now show results in women?
9:22Will it show results at this dose, right? They want to go back and use the same form that was used in the original one. So since it's its default form, that's the form that's been studied in thousands and thousands of studies. What is creatine hydrochloride? It's the same thing. It's providing creatine, right? And you're attaching something to it, okay? With creatine monohydrate, there's actually a water molecule attached to it. Even though it's dry, there's a water molecule attached. With the hydrochloride, what's attached to it is not a water molecule, but a molecule of hydrochloric acid. salt exactly it's a salt right and so what does the hydrochloric acid do to the creatine it increases its solubility so have you ever seen someone or mixed a glass of creatine monohydrate and water chunky and it's you know you've got all those particles in the bottom yeah you drink it it's kind of gritty so creatine is goes into solution very poorly even though it's hygroscopic which means it pulls water to it, it takes a while.
10:31So when you drink a glass of creatine, because creatine pulls water to it, that's why you hear about water weight, right? It goes into the muscle.
10:39Gary Brecka:Which is the bloating that especially women want to avoid. Yeah, but it pulls it mainly into the muscle. So it's not really like, you know, extracellular. It just makes the muscle look bigger, right? It's more volume. However, if the creatine has not pulled water to it while it's in your glass, and you drink it, and it sits in your intestines, those particles are going to draw water to them while they're in your intestines. And that's the explosive diarrhea you hear so much about with creatine monohydrate. You're going to look great, but you're going to have explosive diarrhea. And so there's somewhere around, I think, 20 % to 30 % of people can't tolerate 5 grams of monohydrate.
11:24Wow, 20 % to 30%. Yeah, 20%. And then if you go up to a 10-gram dose, a single 10-gram dose, it's something like 50 % to 60 % of people cannot tolerate that. Wow. And so that's the benefit of the hydrochloride. It's for those people. I can't tolerate 5 grams of creatin monohydrate. Really? Yeah.
11:47Gary Brecka:So you take the HCL version. So I take the HCL. I take the HCL version too. And that's the only difference is that it goes in. When you mix creatine, hydrochloride, and water, it instantly goes in the solution. I do notice that. It's not pulling any water while it's in your intestines. And so not only do you get fewer stomach issues, but you absorb more of it. So it takes a smaller dose. So you're not taking a bioavailability hit. You're not taking it. Nope. So it's not that one crosses the blood-brain barrier, one doesn't. One is more bioavailable, one's not. It's just that one has more clinical data.
12:24Gary Brecka:The other one, but at the end of the day, it's creatine. It gets into the muscle. It gets into the muscle as creatine and it gains that high energy phosphate. And that's what it does. And where do we suppose that some of the cognitive benefits are coming from? From what I've read, if you don't have enough creatine, because it's also like a methyl donor, if you don't have enough creatine to donate methyl groups, then the body's going to grab methyl groups from somewhere. So it's going to grab them maybe from SAMe, S-adenosyl, thiamine. And so when the body is deficient in anything, it doesn't go without, it just takes it from somewhere else, right?
13:08Gary Brecka:I mean, like when we're fasting, we're not eating, but our body is. It's just eating us. And hopefully it's eating you from the weakest point forward, the senescent cells, breaking those into energy or breaking them into amino acids so it can still build structures in the body, which I find just so insanely innately intelligent. That's why I always say, the more I study the human body, the more I believe in God. We don't have to go down that road. But our body's just so intelligent. And so from what I can gather, the line that I draw for creatine and neurocognitive decline and the memory studies and also the sleep deprivation is that if you don't have enough of these methyl donors or creatine, the body's still going to get it from somewhere.
13:55Gary Brecka:So it's stealing it from places that you might not want it to steal from. Yes. Is that a fair assessment? For sure. There's so many ways that it's working. And at the end of the day, it's providing energy to the nerve cells. So just like a muscle now can do more work, right? So can a nerve cell. If you know me, you know I'm a huge believer in the benefits of hydrogen water. H2Tab delivers cost-effective portable tablets that generate ultra-clean molecular hydrogen at 12 parts per million, one of the highest concentrations on the market. With over 1 ,300 published studies showing benefits of oxidative stress, energy, recovery, brain function, and so much more, taking charge of your health has never been easier or more cost-effective.
14:45Gary Brecka:Just drop a tablet in water, let it dissolve, and drink it back. It's less than a dollar a day. science-backed and part of my daily routine. I never travel without this, and it is my favorite biohack. Visit drinkh2tab.com. That's drinkh2tab.com and upgrade your hydration today. Now let's get back to the Ultimate Human Podcast. Sure. And I mean, and at the end of the day, all of these advanced memory decline diagnoses, Alzheimer's, dementia, early onset cognitive decline, memory loss, cognition issues, these are all at their root, neuroinflammatory issues. More circulation, trapped histamines or cytokines or what have you in the brain.
15:35Gary Brecka:And I guess the evidence is that creatine can cross this blood-brain barrier in high doses and maybe mitigate some of those effects. So would you make the blanket statement that at a certain age, everybody should be on a certain dosage of creatine or not quite yet? I would. I mean, I would do. I mean, I would totally agree with that. I would, I would, I think most people should consider at least a five gram dose per day. Yeah. And I'd love to talk about, you know, when we were in the kitchen, we were talking about your transition from pure academia, you know, into the practical world. And it started with, which a lot of our listeners are not going to know.
16:17Gary Brecka:With like Joe Weider and, you know, back in the day when bodybuilding magazines were like the only access that, you know, young athletes or young bodybuilders had any real information. That's a good point, you know. On how to build muscle. That really. And recover. Yeah. Yeah. Where else would you learn about metabolism or macronutrients? So what was your departure from academia like into, let's just call it the real world, right? The practical real world. It took a while to get used to, to be going from - Where did you land out of academia? Yeah. So I left, I was at Yale School of Medicine and I landed at Weider Publications in Los Angeles.
17:07which, you know, Los Angeles was the mecca of bodybuilding at the time. And I worked for, you know, Joe Weider's Muscle and Fitness. We had Shape Magazine. Many people may remember. I remember that one too. For women. We had Men's Fitness. And then we had this hardcore one called Flex, which was like IFBB bodybuilding. It covered all the contests and whatnot. And so I would write for all those, you know, different audiences. You know, some were more hardcore. Some of them were just fitness-oriented.
17:42Gary Brecka:Yeah. But, you know, at the time, you know, bodybuilders were kind of leading the charge on hormone therapy, supplementation, nutrition. Because, you know, these guys shared a lot of data. They were very open about their, you know, their stacks and their cycles and what was working and what wasn't. And even then, you know, they were checking biomarkers long before people were even doing annual blood work. Most people got their blood worked on every maybe five years, unless something was wrong. Isn't that crazy to think about? I mean, now it's sort of become the norm. But bodybuilders back then were not just flying blind.
18:17Gary Brecka:I mean, they were experimenting on themselves. Like, is this hurting my liver? Is this hurting my kidneys? Is this causing my inflammation to go up? And I remember, you know, even back then, reading before I even knew what biomarkers was, it was even before I had my first biology degree. But there was a lot of good information in there that was coming from that, you know, coming from the bodybuilding community. So then you gravitated towards actually creating a supplement line. I think it was born out of need when we talked about your background. Because here you are as an editor for these magazines trying to provide quality information to the reader.
19:00Gary Brecka:and you seem to get very frustrated by the lack of disclosure that was going on in the supplement space. Or what we call proprietary blends. Right. Right. And also, you know, supplement manufacturers just throwing things on the label like creatine, but putting it in dosages that were - Yeah, what I call buzzwords. Yeah, buzzwords. Yeah, you know, creatine, alanine. Yeah, yeah, sounds great. Like I want both of those, you know? And if someone that didn't have the background that you had saw it on a label, they're like, okay, this must be a good supplement. But what's the dose? Every ingredient is only going to be effective at a certain dose.
19:41Gary Brecka:Creatine is one of those, right? Yes. Like I said, I'm recommending about five grams per day for most people. and I was reviewing supplements that had 250 milligrams of creatine or 500 milligrams. So 1 20th. Yeah, like 500 milligrams is half of a gram. And I'm telling you, you should have five grams. They're giving you a half of a gram. And, you know, that's what was so irritating to me that so many companies were taking advantage of consumers who just read creatine, beta alanine, that don't understand you need a certain dose of each one of those ingredients for them to be effective. You know, I feel the same thing going on in the biohacking space.
20:26Gary Brecka:You know, I told you I have a graveyard of, like, red light beds in my garage downstairs. It was very astounding to me how some of the leading brands, $100 ,000 red light beds, for example, very often did not have the nanometer wavelengths, the milliwatts of irradiance. We're not creating a therapeutic dose. And if you accepted the manufacturer's published data, then, you know, and of course, if you're paying$100 ,000 for, you know, red light bed, you expect that it's going to work. And what I found was a lot of these were just red light bulbs. Like you might as well stand next to a Christmas tree.
21:03Gary Brecka:And it was frustrating for me too. And I feel like as someone has a large audience in the space, we have an obligation to - Yes, exactly. Stand in between the consumer and a lot of these manufacturers and say, this is valid and this is not. And the same thing in the supplement space. And so for you, that led to you formulating your own supplement. Yeah. You know, I had to, you know, like I would be telling people what to look for and it was almost impossible to find, you know, which was, you know, ingredients that, you know, studies behind them and it lists the actual dosing. And that trying to find supplements like that was very difficult.
21:45Gary Brecka:Yeah. Things like natural flavors, proprietary blends. Those are sort of buzzwords for we're not telling you. Yeah. Right. Exactly. Yeah. We're not going to disclose. And so instead of just telling people, this is what you should look for, I provided the example. And then how did that go for you? Very well, because, you know, I had been, you know, I had already been teaching people. how to use these ingredients and how to build their own, you know, before you work out, what you want to take after you work out, whatnot. And so the formulas already existed. So when I manufactured them, those same formulas were still there.
22:25And so the consumer already knew they were taking it, just making it on their own. This was going to work because they're already taking it, just mixing it themselves. Now this is actually flavored one scoop and it was in one spot yeah so it ended up being a really good
22:42Gary Brecka:very successful journey for you and it ended up in GNC and yeah there was a very popular brand again because this was in 2013 and at the time most supplement companies were not telling people how many grams of creatine or whatever was in there and so um you know this was somewhat groundbreaking in the supplement industry. And I think you find this, you know, not just in the supplement industry, but also in like, you know, equipment industry. And you see a lot of, or at least I see a lot of good data provided by a certain clinical study. And then everyone just borrowing that data, but not really following the threshold doses.
23:29Gary Brecka:Or, you know, we talked about this in shake plates, for example. Not all shake plates are created the same. I mean, there's certain concussive forces you have to create to improve bone mineral density and drain lymphatics. But the consumer doesn't know that, you know, one vibration plate is different from another vibration plate. They just think all vibration plates are the same. And they can cite, you know, the outcomes from a different product and just sort of borrow that data and allow the consumer to assume that that data is valid in their product when it's not. You know, you have to meet certain threshold standards.
24:01Gary Brecka:What do you think is the biggest hole in the supplement industry right now for the consumer? Like, where are they going wrong? I mean, how does a consumer, in other words, pick something up off the shelf, you know, a supplement, and kind of ensure that they're getting what they're expecting to get? Yeah, well, you know, I created this sort of paradigm that I call the five pillars of supplementation. And so it's based on, you know, a solid nutrition foundation because you can't supplement a bad diet, right? Right. First thing you need to do is create a stable, proper diet, whatever that's going to be for you, right?
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24:44Gary Brecka:Right. We could debate. Whole food based. Exactly. Right. But a whole food based, right? Once you have a solid nutrition plan, then you can start looking at supplements to help take your performance or body composition further, right? And so the first pillar is the ingredients. And that is, do they have clinical research supporting their effectiveness, right? The second one is the form. What's the best form of that ingredient? Is it going to be the creatine monohydrate or the hydrochloride, right? The third is, what is the dose? Minimum effective dose. Of that agrania, right? Is the dose on the bottle, at least the daily dose you're getting, similar to the daily doses in the literature and the published studies?
25:34Fourth is, are there any synergies in that formula? Ingredients that may work together, right? And support one another. For example, if you had brand chains and creatine together, leucine can increase insulin to some degree. And creatine requires insulin to get into the muscle. That would be a good synergy, right? Are there any synergies that are going to promote the ingredients themselves even further than they can by themselves? And then the fifth pillar is timing. When do you take it, right? When is the best time to take the creatine? And is that, yeah, that's, when is the best time to take creatine?
26:15Well, with food. With food? Yes. Because like I said, to get into the muscle at least, right? Brains is a little different. We're still confused about brain. But at least we know about muscle, right? And it requires insulin. Insulin helps to shuttle creatine into the muscle.
26:32Gary Brecka:Okay. So if you have creatine with a meal, right, protein and carbohydrates, you're going to have an increase in insulin that's going to help to drive that creatine to the muscle. So creatine is in some ways you should take fast. You could, but with a meal, you'll take up about, it's estimated around 30 % or 40 % more protein you'll take up. Oh, wow. Okay. So you could take it fasted, but you're just getting less of a dose. Because I work out fasted. I take something called Perfect Amino, which is just all nine essential amino acids. I don't like the full feeling, but I eat right after I'm done working out.
27:14Gary Brecka:you know working out i mean eating before i work out for me is just not something that works for my body and and i don't get the blood sugar crashes you know sometimes i we work with about with these guys at my son's house and there's guys passing out and throwing up all the time because their their their blood sugar is tanking um so they probably should eat before they work out but let's let's actually talk about a good um because rarely do i speak directly to like the middle-aged men my age we're both in our 50s you're clearly holding a lot of muscle for a guy in your in your 50s so what is the secret to maintaining you know a muscular physique and not getting injured um you know when you get into your 50s because i think i think you're so smart by the time you get in your 50s because you realize you can actually get hurt yeah my son doesn't think he can be killed by a bullet neither one of my sons um just because they haven't been really hurt yet.
28:11Gary Brecka:And like, you know, they haven't blown discs, back squatting or anything. I used to race motocross. Oh, did you? Now when I race motocross. So you know you can get hurt. Now when I watch motocross, I'm like, why would I do that? Yeah. You know? So many ways to get hurt, you know? Now we're like, bungee jump, hell no. What was I doing? Yeah. How am I still alive today? Yeah. I have no idea. But yes, you know, you think nothing's going to hurt you. you know, until you get older. But the secret to building muscle after 50 is protein and leucine. Leucine. So once you hit 50, you're in anabolic resistance.
28:56Gary Brecka:Sarcopenia, right? Well, not even just sarcopenia. What anabolic resistance is, it means if... How old are you? Max over there? Yeah, Max. How old are you? 27. Little youngin. If Max eats a steak and let's say provides 30 grams of protein, and I eat that same steak, right? We sit down in your kitchen together. I offered you a steak. You turned it down for the record. Yes. He's fasting right now. If we both ate that steak, you know muscle protein synthesis, right? After you consume protein, right? muscle protein synthesis spikes up. Well, the muscle protein synthesis that Max will get is going to spike up probably about 40 % to 50 % higher than mine will spike with the same meal.
29:52Why? Leucine. So our intestines steal more leucine.
29:58Gary Brecka:They do, okay. And leucine is the key that turns on the muscle building. Because I've always seen in branched-chain amino acids, leucine, isoleucine, vein. and leucine is usually in a two to one to one ratio. So leucine is double isoleucine and valine. And I assume that that's because there's good research behind that. Yeah, and it's what sort of, it's how it is in the muscle. It's typically at a two to one ratio as well. Okay, so that's where that ratio comes from. And then, but I've also heard that branch chain amino acids on their own is sugar water. Well, yes and no. Okay. Right? And so when you do a study, you can bias a study.
30:37before you even do the study. And so the studies on branching saying it's basically flavored water is comparing branchings to essential amino acids, right? Branchings are essential amino acids, but it's only three of them, right? So they compare, they take people and have them fast, and then they consume either branchings or essential amino acids, right? And then they see muscle protein synthesis. Well, it goes up more with essential amino acids because the essential amino acids are also providing the branch chains, but it's also providing the 17 other amino. Right. But that's not how you would use branch.
31:22Nobody would wake up in the morning, fasted and go, I'm going to take some branch chains and call it a day.
31:27Gary Brecka:Right. Right. So here's how I use branch chains. So I was saying the leucine, right? So leucine gets stolen by your intestines. The older you are, the more leucine. It sequesters. And that's why the muscle protein synthesis isn't going up as high. So why not take more leucine with your meal, right? And when you want to take leucine, you want to take branch chains because of the two to one to one ratio, okay? The leucine works best when the isoleucine and the valine are there. Okay. Because they do other things. Well, leucine turns on this process called mTOR, right? The valine and the isoleucine do other things that help with the muscle protein synthesis.
32:13So they work better together. So what I do is I take the branch chains, not with the meal, because research has shown, and get this a little complicated, the research has shown that when you take the branch chains with the meal, the branch chains never show up into the blood for some reason. They still get sequestered. So what I do is I take bran chains about 30 minutes before I eat. Ah. So that the bran chains can get through. Right. They turn on the muscle protein synthesis.
32:43Gary Brecka:Then you have the whole food providing the rest of those essential amino acids that the leucine is now going to use, right? Because it turned on muscle to build the protein. Guys, early access is finally here. and I could not be more excited to launch the ultimate filtered showerhead from Cold Life. You've heard me say it before. Your skin is the largest organ in your body, and it is not a barrier. It is a gateway. Every single day, it absorbs chlorine, fluoride, PFAs, and heavy metals straight from your tap. This showerhead eliminates those toxins instantly, and it's the simplest way to protect your health, doing something you're already doing every single day.
33:25Gary Brecka:It installs in 60 seconds. It has incredible water pressure, and it's finally live. Go check it out now and use my code ULTIMATE10 for 10 % off. Be one of the first to experience the ultimate showerhead. Now let's get back to the Ultimate Human Podcast. So are you still a big proponent of get the majority of your protein from whole foods? Yes and no. What's interesting, what's interesting is, right, and we all say, I even said with the five pillars of supplementation, you want a solid nutrition foundation, right? And that's typically whole foods. But what's interesting about whole foods and muscle protein synthesis is that when you consume a steak, and let's say it has two grams of leucine in it, and then you consume just two grams of leucine by themselves, okay?
34:23Mm-hmm. Not only does the leucine by itself get into the blood faster than the steak, for obvious reasons.
34:30Gary Brecka:Right, because it's coupled. But twice as much leucine shows up in the blood from the amino acids as it does from the food. Wow. Twice as much. And so it's estimated that a whole food, say a steak, will only provide you somewhere around 50 % of those amino acids. A protein shake may provide closer to 70 % of those amino acids. Like a whey protein. Free-form amino acids will provide probably about 90 % to 100 % of the amino. They just took the amino acids themselves, right? Okay. So looking at that, right, you would say, well, it'd be better to just take the leucine or a protein shake than the whole pot.
35:17But remember, what else is in the steak that you're not getting?
35:23Gary Brecka:B vitamins. Right. So it's complicated. And so both are, for me, both are important, you know, and it's using both properly. And like I said, I'm going to take the branch chains right before my whole food meal. Like I said, 30, 20 minutes before. Before your whole food meal. And then I'm going to have my whole food. So what does a typical day in the life of Jim Stobani look like? I mean, clearly you're doing resistance training. And would you say that, especially for middle-aged men, if I only have 30 minutes or 60 minutes to work out every day, cardio or weight training, or is it important to do cardio and weight training?
36:11Gary Brecka:Because I have actually seen some very prominent folks that I have a high level of respect for, well credentialed say if you only have 30 to 60 minutes weight training beats cardiovascular training hands down uh in every clinical study that they had ever yes yeah and so if you only had a certain amount of time and also people that don't think that weight training can actually give you a cardiovascular benefit are not weight training right right just like you're just lolly gagging around the gym yes sometimes i want to take a knee you're doing like five reps on the bench press and then sitting on your phone for five minutes right right if you keep a pace try you know supersetting or keep your rest periods shorter to get your heart rate based depends on the goal but you can and like you said if you had one or the other i would pick resistance training because you're going to get the resistance for the muscles which are critical with sarcopenia as you're aging right quality of life but you're still getting cardiovascular right it's not like there's no cardio.
37:10And again, depending on how, now I'm very fast paced. I superset.
37:15Gary Brecka:Oh, you do? All the time. Yeah. So I'll do a chest and a back, you know. So push pull. Yeah. Okay. Pretty much. So how are your, like some takeaways for my audience, you know, how are your workouts structured? Are they structured push pull? Is it one body part per day? So many different regimens out there. Do you go almost to failure to stop one rep shy of failure? That seems to be a lot of evidence around that. Do you do drop sets, try to fatigue the muscle through the full range? Because there seems to be evidence around that. There's progressive resistance. I do all of it. You're not helping me, Jim.
37:55Gary Brecka:I want the one best way, dude. There's no one. There's no one. That's the great thing about resistance training. There's a million ways to do it you know there's a million different modalities you can use free weights bands um pneumatics you know uh what have you right still going to provide similar benefits you could train heavy you could train light you could train fast you could train you know what i'm saying depending on your goal it's going to provide benefits right you know for overall for me right now like you said um i change up which muscle groups i'm doing in a workout right now i split my body into two different workouts i have a leg and shoulder day and then i have a everything else basically chest back arms okay and you're doing all of those on the same day No.
38:53Okay. Well, one, so two workouts, two different days. And then I typically train either four times a week with resistance training or sometimes even more.
39:06Gary Brecka:Five times a week. Yeah. And are you, are you intentionally doing cardiovascular training or are you getting that through your weight training? I get a bit of it through my weight training, but I also do, you know, I like hiking. Well, that's the best way to get it. High intensity, interval training. I, you know, I mix it up. For the greatest hypertrophic effect in the least amount of time, where does the research say the greatest benefit is from? Training to within one rep max? Yeah. Drop sets? What does it say? Yeah, I would. And again, it's going to depend on the individual, right? Somebody who's advanced is going to want to do drop sets and go to failure.
39:45Somebody who's got a year or less under their belt, close to failure. Okay. is plenty.
39:54Gary Brecka:And, and, and you're a big fan of consistency over time versus high intensity for short periods of time. And you talk about programming for the middle-aged lifter is way different than programming for the 22 year old. So how do those differ? So I would say for the middle-aged and older, you want a more well-balanced fitness routine, right? Like when you're young, you might have like, Oh, I want to be, you know, stronger or faster because I play pickup basketball or, you know, whatever it is. Right. I skateboard. I do some of this as you're, as you get older, I'm 50, right? Will I be able to get my biceps any bigger?
40:38Probably not. Right.
40:40Gary Brecka:Yeah. Right. Will I be able to bench press anymore? Probably not. Will I be able to run any faster than I can right now? Probably not. Right. So instead of trying to focus on like one goal and maximize that, whatever it is, whether it's the strength, right. As you're aging, right. What is important? Mobility, right. Maintaining muscle, metabolic health, not getting hurt. Right. And so the older person I think needs more variety. And in fact, there's research suggesting that those who work out with more variety versus I just lift weights or I just run have more longevity. So it's actually the variety.
41:35Gary Brecka:Another, I think, really hot area is gene regulation research. And I know you have some core competency in this, myostatin inhibitors and some folistatin gene therapy. And these seem very promising to me. I don't know where you fall on that, but folistatin, for example, inhibiting myostatin, which is what sort of stops our muscles from growing, for lack of better words. It's a governor. Yeah, governor. It's like a governor on muscle growth. Yeah, so taking the governor off of muscle growth, where do you fall in some of these gene therapies? And do you see those becoming a little more mainstream?
42:14Gary Brecka:I think it's very exciting. I don't know about it becoming mainstream anytime soon, but who knows? But what are you excited about in the future? Well, you know, when I was a teenager, I used to eat fertilized eggs. Do you know why? Because of the folistatin, which reduces myostatin, right? And so all these bodybuilders, because no one else knew, swore you had to buy fertilized eggs. What is a fertilized egg? An egg that's been fertilized. That can grow a chicken versus the ones you get at the grocery store. Okay. Because of the foster. How do you buy fertilized eggs? I'm very excited. In fact, there was a company that came out with a myostatin inhibitor from egg yolk.
43:09Right? That's what they got, the folistatin. However, was it effective? Right? There's research that shows if you take a myostatin inhibitor like folistatin, like this one supplement company, the exact product, it dropped myostatin by about 40 percent okay in middle-aged men right wow impressive right yes however the product didn't sell that well i tried it didn't do much for me either why well i'll tell you why do you know how to lower myostatin working out lowers myostatin in creatine by about 30 to 40 percent. Wow. So if you take a person who's already working out, already taking creatine, they've already lowered their myostan levels by 30 to 40 percent.
44:05Will this ingredient lower it anymore? No, it doesn't appear to. Will gene therapy? Yes. Okay. That's different, right?
44:15Gary Brecka:Because that's a direct shutoff of the gene. turning on and off versus trying to turn it off. I'm very excited about, you know, and you've seen the case studies of these infants that have, you know, both myostatin genes have been turned off, you know, and they're like... Muscular. Yeah. Yeah. Little infants. You're right. Yes. So I'm, you know, very excited. I wish I had that. access to so are there any good folistatin gene therapies that are really available today when i went down the rabbit hole of it it's like you got to go to nicaragua or like it's just one place in the world where you can actually do these because they're not approved it's just too early in the game you know what i mean to really pinpoint where um but it's exciting you know it's it's exciting what else on the gene front are you excited about if anything because i've heard dr mike talk about um some of these new gene therapies and I don't profess to remember the names of some of these, but about how these could potentially replace a lot of these anabolic steroids that bodybuilders are using to gain this kind of muscle mass.
45:31Insulin growth factor. Yeah.
45:33Gary Brecka:Instead of the old school, just Anavar and Tren and testosterone and DECA and all of these other things, which have clear side effects, especially long term. Yeah, but we don't know what, you know, changing this gene could also. Yeah, it always freaks me out a little bit too. Like CRISPR kind of freaks me out a little bit. It's got a lot of promise to like delete genetic mutations, but then how far do we take it when we start like designing the genome? Yeah. And, you know, against our, you know, the natural intention for this replicatory cycle. Yeah. You know, and it seems like every time we really mess with mother nature, something really bad happens.
46:12Gary Brecka:I remember growing up, I grew up on the Chesapeake Bay and there was, you know, they wanted to add, get more oxygen into this estuary, which is a mixture of like salt water and fresh water. And so it used to be fertile for like oysters and crabs and, you know, Maryland crabs. I mean, I grew up on Maryland crabs. and so a bunch of scientists put this algae into the bay coated the whole bottom of the bay blasted the oxygen content up in the water and then dead fish were floating everywhere for years i mean just jacked up the whole ecosystem yep and i feel like we might be going down that road human beings if we if we jump on the bandwagon yeah you know that's why i you know i always have concerns anytime there's something promising it's like well what else is it going to do is is what i always think you know so so in general let's get back to the middle-aged male versus the 22 year old male because i'm middle-aged and i work out with both my sons who are in their early to mid 20s um and i love working out with them and i actually feel great my joints don't hurt and i'm performing these workouts i love i say the same thing i feel very lucky that i very amen joint issues yeah because i've had them in the past you know i've had an acl injury i've had low back injuries i mean that is the worst right so i mean for me number one is like don't get hurt yeah um because that and then that sets you back i mean if you get an injury it sets you back six months it's a year before you really get back to where you were especially at this age yeah um so what are the big hallmark milestones of you know middle age let's call it 45 years and older versus early 20s for workouts is it volume is it weights is the complexity of movements you know i I owned a CrossFit gym for a while, and I saw a lot of people getting hurt doing complex Olympic lifts.
48:02Gary Brecka:Those are not necessary either. No. I'm afraid for compound snatches. You know what I mean? It's like... You know I'm all about optimizing performance, and lately I've been using the ion-weighted vest during my workouts, and it's been a game changer. It isn't your average weighted vest. It's designed to fit like a second skin, activating your core, improving blood flow, and even helping you with recovery while you train. What I love most is that the weight is perfectly distributed. It doesn't pull on your shoulders or throw off your alignment. Whether I'm doing strength training or cardio or just taking a walk, I'm burning more calories, building muscle, and pushing my endurance even further.
48:41Gary Brecka:If you're serious about leveling up your training and unlocking your full potential, check out the Ion Weighted Vest at Iongear.com. That's A-I-O-N-G-E-A-R.com. And you can use code ULTIMATE for 10 % off and start training smarter today. Now let's get back to the Ultimate Human podcast. That's, you know, as an exercise scientist, you know, those are the things that are frustrating. It's like I have many CrossFit friends, you know, and it's like I love the value of CrossFit. What I think CrossFit did well is it opened up Olympic weightlifting to everyone. Now, on the flip side, do we want to really open up Olympic lifting to everyone?
49:22because you have to be very proficient at it.
49:26Gary Brecka:You can't just go in there and whip out 30 reps after you've run a mile around the gym. That's not how Olympic lifters train because you can get injured that way. Yeah, and I saw it. There's a better way to do it. But anyway, so on the middle age, You know, like I said, I'm more about being more proficient in all levels of fitness, your flexibility, your mobility, right? Your strength, muscle mass, because we want to avoid as much sarcopenia as possible. Which is age-related muscle racing. Yeah. And so I'm, you know, as far as the actual workout design, obviously it's not just about age. It's also, where is this person?
50:18Are they just starting? Have they been working out for a year? Have they been working out for five years? Have they been working out all their life? Right. Those are different, even though they're all 50, right? These are all different. they would require different workouts because it's more about about the individual but on a you know on a basic breakdown i would say a variety of repetitions you want to do some heavy stuff right because that's going to activate those fast twitch fibers i think you want to do some lighter stuff as well for more endurance based right and and lighter weight now is finding to be more hypertrophic, better for building muscle, right?
51:01But then I would also include yoga into your routine. I would also include cardio as well, so that you're getting all those areas. You're getting mobility, flexibility, cardiovascular, muscle building, strengthening, et cetera.
51:19Gary Brecka:Where do you fall into post-workout nutrition? Because that's, talk about an area where people get paralysis of an ounce. The anabolic window, which I heard has totally been thrown out. And so Brad Schoenfeld is the one, and Brad is a friend of mine, you probably know the name, who published that study. Now, it's a study of studies, as we talked about, right, to conclude that maybe the post-workout window isn't as important as we once thought, right? But the studies are only as good. The study can only be as good as the studies. And the problem with sports nutrition research and bodybuilding research is there just hasn't been enough of it done.
52:05You know, most of the research that's done, like with carbohydrates and post-workout, is for endurance athletes. And looking at if they have carbohydrates immediately after, how do they perform the next day? and so we've taken all this indirect data and tried to apply it to how a bodybuilder should train and eat right and so uh brad did this meta-analysis on all these studies and post-workout nutrition finding that maybe it doesn't really matter however in the same note he will say i would never tell a professional athlete to not eat immediately after they work out i would never this is this just means the average Joe and Jane who want to go to the gym do not need to down a protein shake as soon as they're done working out okay to catch the
53:01Gary Brecka:anabolic window as long as they eat within you know an hour is fine right right an NFL lineman would I say the same thing to him Brad would say no I would tell him to eat as soon as he could you know and so the the the whole the post anabolic window is dead thing has been overplayed because it's really look if you just want to be fit and healthy you don't need to run home and get your protein shake asap does a professional athlete want to do that probably Right. Okay. That makes a lot of sense to me. And that's Brad's own words. And I parrot that. Would I tell somebody who wants to gain an extra quarter inch on their biceps, is that important to them to not eat right after?
53:57No, I would suggest eat. And the other way to look at that is to build muscle, right? You need so many times in the day where you spike muscle protein synthesis, right? And what the research is showing is three meals is better than two. Okay? Four might not be better than three, but three appears to be better than two, right? So you need to get at least three good high-protein meals in a day to maximize. So if you work out and then wait three or four hours to eat, that's going to lessen the number of windows you can have. so my take is eat right out as soon as you can right as soon as you can you know what i mean
54:43Gary Brecka:so what are the from a supplementation perspective what are the important ones to get the timing right on the the timing right would be and again it you know it depends on the goal for all these because like you can argue with creatine right i would take it with a meal however many people take it on an empty stomach and and it serves them well like i said there's a difference of about 30 or 40 percent more uptake into the muscle when you have it with a meal okay okay maybe increase your dose if you're taking it fasted yes you can still right you can still get benefits from it um something like beta alanine for example right which helps it helps buffer uh acidity in the muscle to help prevent fatigue right that one i would take before you work out okay because of what it does beta aline yes beta aline i like taking before um because and what's the dosage for that you want to get about around three to four grams per day okay and it's kind of like creatine where you want to take it repeatedly because you need to reach a certain level.
55:56Gary Brecka:So not the three or four grams first thing in the morning, saying gram, gram, gram. Yes. Okay. But it also is a bit like caffeine, where it gives you a little bit of a pick-me-up, a slight one. And so people who take it at night may notice they can't go to sleep. And so I'll typically recommend that one either earlier in the day or before they work out. Okay. Things like that. So if the FDA were to outlaw all but three to five supplements tomorrow, which would be the three to five that you'd say these are kind of must-haves? If you're on this strength training journey, I think that the data is very clear now.
56:40Gary Brecka:Muscles are metabolic currency, leg strength, grip strength, BO2 max clearly correlated to longevity, decrease in cardiovascular risk, You know, mitigating a lot of the major risks of older age, falls being probably the greatest. So what would be those three or four must-haves to sift through the noise? Sounds like creatine is one of those. Definitely. Okay. Top of the list. Okay. Definitely creatine. Beta alanine. Safety and effectiveness. Safety and effectiveness. Beta alanine for an athlete, I would probably say yes. For someone who's just looking for health and fitness, I don't think it's that critical.
57:21Something like fish oil, right? I would say that's not as critical because you can get that from whole foods. Right? Something like that. Yeah, I'm a big fan of omega-3. I would say branch chains or essential amino acids, I would put on that list. Because as we talked about, you're only getting, you know, maybe 50 to 60 % of the amino acids from your whole food meals. right and so for somebody who's older who just wants to spike your muscle protein synthesis more okay being able to take those like i said branch chains are the essentials which are providing the branch chains as well is going to be important um what else do i have on that list i also want to well i'll let you finish that list and then i want one one final question for you on one particular nutrient yeah it's hard to come up with a list because like you said, supplements are more goal oriented, right?
58:16So it would depend on the person, you know, like it would be different for an athlete versus a 60 year old who just wants, you know, to maintain longevity.
58:27Gary Brecka:So then, um, however, creatine would be the one. Yeah. Creatine, don't let them outlaw that one. You know, is really the, the list, you know, that the one that everybody should really. Must have. Um, where do you fall on, uh, Or do you have an opinion on NAD, NAD plus? Yeah, I think it can be very effective. Do you take it? As NMR, right? Nicotinamide mononucleotide? Yeah. Or nicotinamide riboside? And if you're infusing or orally. Well, let's take like an oral in your supplement stack. I would do the NMR versus NAD. Nicotinamide riboside? Yes. Nicotinamide mononucleotide, the NMN? Yes. NMN. Okay, so NMN.
59:14Gary Brecka:I think I would absolutely agree with you. I think Dr. David Sinclair would agree with you too. Like increasing our body's ability to make it naturally rather than just taking it in. And I think there's some - And that's, as you were talking about, as we get older, that's one of the things that will decrease. Yeah, yeah. The liposomal versions I see from like Symbiotica and some are phenomenal. Those are the ones that I notice and they actually, I think the liposomal deliveries for nutrients like that are critical because a lot of those are just denatured, first-class metabolism. You'd probably agree with that too.
59:50Gary Brecka:So I appeal to so many audiences, but I rarely talk to the guys that are like my age. And I actually want to look more like you look than what I look. So I'm going to follow your advice. Maybe I'll even start taking some of your supplements. But I wind down all my podcasts by asking my guests the same question. And there's no right or wrong answer to this. But what does it mean to you to be an ultimate human? What it means to me to be an ultimate human is to perform at my best that I can at that time, right? Whether, you know, I may have certain injuries or limitations, right? It's the performance, but it's also about how I treat other people.
1:00:36I think it's just being kinder to people is important to me.
1:00:41Gary Brecka:You could use a lot of kindness in this world right now. Right. For sure. Well, I've got a lot of VIPs waiting for you in the other room that got a bunch of questions for you. If you're interested in becoming a VIP and joining my VIP community, getting one-on-ones with me and getting into some of our private chats and using the Ask Gary Anything AI, which I can look at your blood work, look at your gene testing, evaluate your supplement stack, you can head over to the ultimate human.com forward slash VIP and join my VIP community. I would love to see you in there, Jim. This has been, uh, amazing because you're, you're clearly walking the walk and, and talking the talk.
1:01:17Gary Brecka:I think your background is very unique in the industry. Um, and you know, your grasp of supplements and what's effective, what's not, uh, I definitely want to continue to follow your journey. I hope you'll come back on the podcast at some point in the future. And until next time, guys, that's just science. Bones.
From the publisher
Jim Stoppani, PhD, joins Gary Brecka to explain anabolic resistance, why leucine decides whether a meal builds muscle at all, and why he takes his branched-chain amino acids 30 minutes before eating instead of with the meal. Plus protein absorption from whole food versus whey versus free-form aminos, cardio versus weights when time is short, and how to train after 50 without getting hurt.
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Timestamps
00:00 - Intro of Show
04:48 - Creatine as an energy molecule
07:04 - Creatine's brain and memory benefits
07:48 - Creatine and sleep deprivation
08:35 - Monohydrate vs hydrochloride
11:17 - Why creatine wrecks your stomach
16:02 - From Yale to Weider magazines
19:16 - Buzzword labels and underdosing
24:22 - The five pillars of supplementation
26:14 - When to take creatine
28:41 - Building muscle after 50
29:08 - Anabolic resistance and leucine
30:24 - How to actually use BCAAs
34:24 - Whole food vs shakes vs aminos
36:25 - Weights vs cardio on a time budget
41:32 - Myostatin and gene therapy
51:19 - Is the anabolic window dead?
54:15 - Three protein meals beat two
56:21 - The must-have supplements
58:39 - NAD, NMN and aging
1:00:14 - What it means to be an ultimate human
Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.
Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
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