Own the Role You Have: Novartis CEO Vas Narasimhan

3 Mar 2026 · 34 min · 16 chapters

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Executive Decisions Podcast: Episode Summary

Podcast Title

Executive Decisions with Steve Sedgwick Description ‘Executive Decisions’ is a CNBC podcast hosted by financial journalist Steve Sedgwick. The series offers insights into the pivotal choices made by influential business leaders and policymakers, highlighting their experiences with risk, doubt, and conviction.

Episode Title

Commit Fully Now: Novartis CEO Vas Narasimhan Description In this episode, Steve Sedgwick interviews Vas Narasimhan, CEO of Novartis. Narasimhan discusses his immigrant roots, his career journey, and the critical decisions that have shaped his leadership style and the direction of Novartis.

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Key Themes and Insights

Immigrant Roots and Personal Philosophy

  • Background: Narasimhan is the son of Indian immigrants. His parents instilled values of humility, kindness, and the importance of making a positive impact on the world.
  • Influence of Parents: His mother, a nuclear engineer, and father, a corporate executive, inspired him to view opportunities as a means to effect change.
  • Cultural Identity: Growing up in Pittsburgh, he strived to balance his Indian heritage with his desire to fit in with his peers.

Career Journey

  • Medical Aspirations: Initially wanted to become a doctor but shifted to consulting at McKinsey, which opened doors to the pharmaceutical industry.
  • Novartis Leadership: Joined Novartis in 2005, where he took on various roles before becoming CEO in 2018 during a turbulent time for the company.

Key Decisions as CEO

  • Crisis Management: Faced significant challenges early in his tenure, including scandals and investigations that required transparent leadership.
  • Leadership Philosophy:
  • Purpose-Driven: Encourages a culture where employees feel connected to a larger mission, focusing on autonomy, mastery, and purpose.
  • Learning from Mistakes: Emphasizes the importance of owning up to past decisions and mistakes.

Company Vision and Strategy

  • Focus on Innovation: Advocates for Novartis to remain dedicated to discovering and developing cutting-edge medicines while maintaining commitments to global health.
  • Tough Decisions: Discussed the difficult decision to eliminate 10,000 jobs during the pandemic, stressing the need for clear communication and respect for employees affected.

Personal Insights and Values

  • Health and Well-being: Narasimhan prioritizes physical and mental health, advocating for consistent habits in mindset, movement, nutrition, and recovery.
  • Future Aspirations: Expresses a desire to guide his children as they transition into adulthood while contemplating personal next steps after his CEO tenure.

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Key Takeaways

  • Embrace Uncertainty: Leaders like Narasimhan acknowledge that uncertainty is inherent in decision-making, and successful navigation requires resilience and adaptability.
  • Mission-Driven Leadership: A strong sense of purpose can motivate employees and drive the organization's success.
  • Continuous Learning: Emphasizes the importance of learning from experiences, whether positive or negative, to inform future decisions.

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Conclusion This episode with Vas Narasimhan highlights the intersection of personal values and professional decision-making in leadership. His journey reflects a commitment to using his position to drive meaningful change in healthcare and society while emphasizing the importance of humility and connection to a larger mission.

Written by AI. May contain mistakes. Listen to the episode to check what was said.

Chapters

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Vas Narasimhan's Early Influences

0:45 to 2:06

Vas discusses his upbringing and the values instilled by his immigrant parents.

“By bringing me back to India many times in my youth, particularly my mom, she would always take us back to say, you've had these extraordinary opportunities to get to the U.S.”

The Journey to CEO

2:06 to 4:30

Vas recounts his career path from medicine to consultancy and ultimately to Novartis.

“in Pittsburgh, Pennsylvania, a steel town.”

Lessons from Leadership in Public Health

4:30 to 6:34

Vas reflects on the importance of leadership and management in healthcare.

“Like, what could you do to impact the world with the opportunities that you've been given?”

The Role of Purpose in Leadership

6:34 to 8:15

Discussion on how purpose drives motivation and the role of leadership in fostering it.

“Now, I had no idea what ended up being a CEO.”

Balancing Family and Ambition

8:15 to 10:07

Vas shares insights on managing family life alongside high-powered careers.

“But I think there's also an element of getting to what are the underlying things that drive people.”

The Decision to Join McKinsey

10:07 to 12:15

Vas explains his decision to transition to consultancy at McKinsey.

“She's got four Harvard degrees, which I hasten to add is more than you.”

Decisions Leading to Novartis

12:15 to 14:00

Exploration of the decisions that brought Vas to Novartis in 2005.

“And I got to apply it in the business world.”

Strange Decisions Lead to Growth

14:01 to 15:48

Exploring how seemingly odd career choices can lead to significant personal development.

“And I think you can learn a lot and have a huge impact.”

Lessons from Early Career Setbacks

15:49 to 17:48

Reflecting on early missteps and the importance of resilience in leadership.

“I've just learned something again from this and the fact that I've had so many conversations with you about and the rest of the industry about biotech.”

Coping with Stress and Challenges

17:49 to 20:28

Discussing the mental toll of leadership challenges and the importance of emotional resilience.

“Tell me about something you got really badly wrong early in your career.”
Show all 16 chapters

Navigating the CEO Transition

20:29 to 24:43

Detailing the complexities and unexpected challenges faced in the transition to CEO.

“Let's spin forward to the succession process from Joe Jimenez.”

Making Tough Decisions During Crisis

24:44 to 26:57

Discussing the difficulty and necessity of making hard choices, such as job cuts during the pandemic.

“And if they haven't been in the ring, and I feel like this on CNBC, I don't want to, I didn't care what they say.”

The Emotional Impact of Success

26:58 to 28:00

Sharing the deep emotional responses tied to the success of life-changing drugs.

“When you get drugs through, drugs that change people's lives.”

Decision-Making Ethos at Novartis

28:00 to 29:25

Learn about the decision-making process and values at Novartis.

“because you put your whole heart and soul into this work.”

Personal Health Decisions of CEO Vas Narasimhan

29:25 to 31:22

Explore how Vas Narasimhan prioritizes his health and wellness.

“And that's hard to tell those scientists.”

Navigating Life's Transitions and Legacy

31:22 to 32:25

Understand Narasimhan's thoughts on family, career transitions, and legacy.

“And I will go for that run again tomorrow.”
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Transcript

Automatic transcript. May contain errors.

0:00Vas Narasimhan:A CNBC original podcast. Every leader's journey is shaped by a handful of defining decisions. Those moments of risk, doubt and conviction that influence their lives and careers. In this podcast, we get to hear the stories behind those choices. Welcome to Executive Decisions with me, Steve Sedgwick. In this episode, I speak to Vas Narasimhan, the CEO of pharmaceutical company Novartis.

0:27Steve Sedgwick:I think it's easy to get too fixed kind of in your career as well. And I think to be open to possibilities that a decision in one direction could open three other decision doors in another direction.

0:38Vas Narasimhan:As the son of two first-generation immigrants to the United States, Vaz's life and career have been guided by a core mission instilled by his parents.

0:47Steve Sedgwick:By bringing me back to India many times in my youth, particularly my mom, she would always take us back to say, you've had these extraordinary opportunities to get to the U.S. to get an education. What could you do for the world? What could you do to impact the world with the opportunities that you've been given?

1:03Vas Narasimhan:After attending Harvard Medical School, Vaz considered becoming a doctor, but instead he went to consultancy McKinsey before settling at Novartis. When he eventually became CEO, the company was embroiled in scandal and faced several investigations.

1:16Steve Sedgwick:Talk about getting thrown into the maelstrom. It's easy to coach new CEOs about these things, but when you go through it and it's the first time it's your name and seeing all of that, But it's jarring.

1:27Vas Narasimhan:These are Vaz Narasimhan's Executive Decisions.

1:37Vas Narasimhan:I've had the privilege of interviewing you throughout your career as a CEO at Novartis, but I haven't got to know you. And as my preparation for this has gone on, I've just found you unbelievably fascinating already as well. Why don't we start off earlier on, though, with your parents and the importance of where you come from?

1:55Steve Sedgwick:Yeah, look, I see what I always say, we stand on the shoulders of giants. And I think about the journey of my grandparents coming from really small villages in southern India, farming villages, my parents making the grand trek from India to the United States, and then growing up as an immigrant kid in Pittsburgh, Pennsylvania, a steel town. but it was a steel town back then. And, you know, they put inside of me the values that I think I cared for today. You know, you try to impact the world in a positive way. You do it with humility and kindness. You're always trying to learn about yourself and learn about the world.

2:32Steve Sedgwick:So it's been, I'm very grateful for all that they've done.

2:35Vas Narasimhan:Your mother was a nuclear engineer. Your father was a senior executive at Hoogunas Corporation as well. Good research, yeah. Well, thank you. We tried. Having a mom, especially, with that kind of pedigree is phenomenal.

2:45Steve Sedgwick:My mom is a brilliant, brilliant person. And she managed to raise three boys while being a nuclear engineer at Westinghouse while still trying to make ends meet. So I think that was really important for us to see, right, growing up. And then my father, having come from nowhere to come all the way up to the executive ranks, even during his career, he would make multiple steps, really high risk steps, leave his job, get another degree, bet on himself again and again, always with this kind of boundless optimism. And I think that carried through into me as well.

3:19Vas Narasimhan:Yeah. I read somewhere that one of your key aims as a young man was just trying to fit in. You know, you coming from an immigrant background as well. Was it hard to fit in?

3:28Steve Sedgwick:Well, you know, I think it was. But we had a beautiful community there in Pittsburgh. Actually, my parents helped found a temple there, the Srivankateshwar temple. And I actually grew up, even though I was growing up in the United States, I grew up really grounded in Indian culture, Hinduism. Books I now still quote, like the Bhagavad Gita, were important in my upbringing. So I always had a sense of belonging there. But, of course, at that time, there wasn't a large immigrant communities in these places where I was going to school. So a big focus was, yeah, just trying to fit in. You know, sometimes it was funny.

4:01Steve Sedgwick:I'd only know the words for things and the language I learned first, which was Tamil, not English. And always trying to catch myself when the kids would then laugh at me. I mean, little things like that. But it was still a wonderful childhood. What drove you as a young man? You know, I think my parents instilled in me this idea by bringing me back to India many times in my youth, particularly my mom. She would always take us back to say, you've had these extraordinary opportunities to get to the U.S., to get an education. What could you do for the world? Like, what could you do to impact the world with the opportunities that you've been given?

4:35Steve Sedgwick:And going back and seeing that, of course, especially at that time in India, you would be seeing that there are, you know, millions, hundreds of millions of people without those opportunities. And so I'm always left with that thought that I've had the privilege to have these opportunities. It's not a given, just the luck of the draw in many ways. And then what can you do with that to make the world better?

4:55Vas Narasimhan:Yeah. Did you always want to be a doctor?

4:57Steve Sedgwick:I think very early on, if you probably saw in the history, even in college, I went to Africa and I went to West Africa and I went to the Gambia to work with the Red Cross. And probably it was that experience that more than any other really instilled in me this desire to pursue medicine and public health.

5:14Vas Narasimhan:Because you also looked at child poverty in India and you were in Kolkata and other places studying HIV treatments in Botswana. Part of me can see how you could have gone down that route and stayed with people at Médecins Sans Frontières and working in humanitarian relief, working in the charity sector as well. I can easily have seen you going that way, given your resume.

5:32Steve Sedgwick:Well, first, I want to make a call out there. You know, when you go back to Kolkata, that was actually the first trip my wife and I took. And we had only been dating for like three months. And we ended up working with street children and child laborers in Kolkata together. So think about a love story. That was like an interesting place to kind of try to go. But it was a crazy, crazy time then in Kolkata. But we managed and it was incredibly rewarding. And then, as you said, to be part of the first HIV AIDS treatment effort in Africa and Botswana was extraordinary. But, you know, through those experiences, I also saw that in many of these, in many ways, management, leadership was not very evolved in public health.

6:13Steve Sedgwick:And so I think my first step into the business world was very much motivated by that desire to learn how to lead, learn how to make change happen at scale. Because I think the history is that usually a great physician is just thrust into a leadership role without any of the experience. And that's what I was observing on the ground. So that's where the initial inclination came from. Now, I had no idea what ended up being a CEO. It was always like, I'm going to go to business and come back to public health. And then one thing led to another.

6:40Vas Narasimhan:That's really interesting because more than one of my guests on this podcast, I always knew I was going to be a CEO. I always knew that was the aspiration as well. But for you, that wasn't the goal. That wasn't, you weren't making an early decision to be a CEO.

6:51Steve Sedgwick:I think the idea of becoming a CEO only fully occurred to me six months before I became CEO of Novartis. Genuinely? Genuinely. But you had a whole series of management.

7:00Vas Narasimhan:We'll come to your evolution of your career from 2005 onwards over at Novartis. But I would have thought that it would have been at the back of your mind.

7:08Steve Sedgwick:You know, when the global head of human resources then at Novartis said I was one of the candidates that they were considering for the CEO role, I thought he was actually joking. I mean, I was like, me? I'm like a physician scientist working on drug development. Yeah, so it never occurred to me. Sorry, Baz.

7:24Vas Narasimhan:You're one of the smartest people I know. How did you not spot that?

7:26Steve Sedgwick:I missed it. But, you know, I'm kind of another thing my parents gave to me was this notion you have to throw yourself fully into whatever you're doing at that moment because who knows what comes next. and don't worry about the result throw yourself into the process whatever role i was in i was all in and i never was thinking about it that's best advice i'd give to young people listening don't always think about the next role i mean think about how you can maximize the experience of

7:51Vas Narasimhan:the role you're in you are a very smart guy although you're the second smartest person in your marriage from what i can see your wife's got more harvard degrees than you that's absolutely true absolutely true but you kind of found it easy to talk to smart people on a smart level but And actually, hence you mentioned the scientists. But on a broader level, not everyone's got your IQ, Vaz. And did you find it hard to relate to the rest of us, the mere mortars of us out there?

8:13Steve Sedgwick:Well, I think there is that element of communication. But I think there's also an element of getting to what are the underlying things that drive people. And really understanding that it's okay that people have different motives and different drive. But you as a leader have to find a way to tap into that and really get people to do extraordinary things. That's what we tell leaders. Leadership at Novartis is getting ordinary people to do extraordinary things. That's what we need to be able to do.

8:36Vas Narasimhan:Autonomy, mastery, purpose. It kind of covers it, doesn't it?

8:39Steve Sedgwick:Autonomy, mastery, and purpose. Yeah, so Daniel Pink's work, and I've talked to Daniel now, it's still ongoing for many years. I still believe he's got it. For most people, once you pay them enough, paying them more is not going to motivate them even more. But it's the idea that they're working for something that's bigger than them, that they have the freedom to do that work, which we later called unboss, and then the opportunity to grow as people. You should really be talking about mission and purpose three times more than anything else. Many people have talked about the Simon Sinek, Adam Grant, many of the leaders that I really...

9:09Steve Sedgwick:Think again, Adam Grant, yeah. You know, start with why. Leaders start with why. And you should be talking about the why we're doing the work three times as much as the what and the how. Because that's what really can motivate people. But the art of it is not just the big, what I've learned over the years, is not the big P purpose always. You also got to bring it down to the little P purpose. I love the story of people who work in our manufacturing facilities, cleaning the facilities. And when you ask them, why do they do what they do at Novartis? They say, we're saving people's lives. Because they've connected the work they do in that facility to the bigger purpose.

9:42Steve Sedgwick:And so you have to be able to make those connections. It's not enough just to say, let's reimagine medicine. Because somebody in our organization, seven to eight levels down, has to understand what that means for them.

9:57Vas Narasimhan:I want to just mention your wife as well, because we've already talked about her. She's an incredible woman in her own right. She's the CEO of Vidosia Farmer now as well. Lives with you in Basel with your kids as well. She's got four Harvard degrees, which I hasten to add is more than you. It is. But you've mentioned her about three times. So she deserves an honorable mention as one of your kids. She's your partner in this, isn't she?

10:19Steve Sedgwick:This isn't just you, the CEO. This is you together, isn't it? Absolutely. And my best friend as well. But I think throughout the ups and downs, we've been on this project, whether it's the streets of Kolkata, whether it's the hospitals of Africa. Now, interestingly, both as biopharmaceutical CEOs. I'm not sure if it's true, but I think we might be one of the few or the only married couple that both CEOs of public companies may be in the world, which is kind of an incredible thing. Yeah, so it's been extraordinary. And I would be nowhere without her, for sure.

10:53Vas Narasimhan:One thing that's really clear is having one amazing career is tough on the family and is tough on the relationship. Having two amazing careers, you must have to make some really tough decisions. And again, this is not a Novartis thing. This is about you and your amazing partner in life. How do you make those decisions about what you prioritize and when you prioritize?

11:13Steve Sedgwick:Yeah, I think early on when the boys were young, we have two incredible boys. Early on, actually, I took the lead. She was traveling. She was a McKinsey expert. She was traveling around the world working on projects. I was kind of muddling my way through as best I could, trying to get the kids to daycare. Then, you know, she took the lead on the kids. And my career at Novartis really blossomed. And then, look, when the opportunity to become a CEO came up, we talked with the boys. And we said, are we willing to do this as a family? And my boy said, we want to make this happen for our mom. And so we figured it out.

11:45Steve Sedgwick:I mean, and so it's not always easy. I don't have a magic formula to make it happen, but we figure it out.

11:50Vas Narasimhan:Quickly, you just mentioned McKinsey. Why did you join McKinsey? After all the most amazing life experiences you'd had from Botswana to Gambia to Kolkata,

11:58Steve Sedgwick:you end up at McKinsey? Yeah, it was interesting. But, you know, I am very grateful. I was there only. I was there for 18 months, 20 months. But in that time, I learned so much for somebody who'd never been, you know, done an MBA or knew anything. I didn't know what a balance sheet was. I didn't know anything about P &Ls and valuation. And I had been trained in medicine. And then I learned all of that. And I got to apply it in the business world. I think of it as I learned another language. Like you have to, as leaders, you have to be able to speak different languages. You have to speak my role, medicine, public health, finance and business.

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12:30Steve Sedgwick:And you have to be able to communicate. And I learned that.

12:33Vas Narasimhan:But that decision speaks volumes to me. You didn't go to one of the big hospitals. You didn't go to a big teaching hospital to carry on that side of your career. You went to McKinsey instead because you knew you wanted to make a bigger impact in health and health services. It wasn't going to be medicine.

12:45Steve Sedgwick:It was going to be scientific.

12:47Vas Narasimhan:I wasn't exactly sure.

12:49Steve Sedgwick:And that's the point. And young people shouldn't be sure. Shouldn't be sure. I mean, I think people watching should know, these were all just experiments. I was in my kind of late 20s. I was like, let's give it a shot, right? Maybe McKinsey will lead to something or maybe I'll just go back to medicine. And I had no idea where it would go. And I had no idea that McKinsey would lead to Novartis, right? So when that happened, and then suddenly I was sitting in Basel, Switzerland, working for a pharmaceutical company. Certainly my mother was asking me, what exactly is the plan right now? So I thought you were going to be working at a hospital.

13:18Steve Sedgwick:You're a Harvard Medical School grad. I'm with your mom. This is where I was going with your history. And it wasn't a carefully thought through plan at all. It was kind of just trying to see where I could learn, where I could have an impact and just kind of follow. So I love this. Huge decision.

13:32Vas Narasimhan:You've had this unbelievably expensive education. I'm sure you got a loan the size of a – well, maybe you didn't. I did, I did. And you've made the decision to go to McKinsey to learn more. And then you've ended up at Novartis, 2005? 2005. Tell me how that process worked and the decision-making. Did you make that more of a decision or were you just winging it still?

13:49Steve Sedgwick:I kind of always thought to follow people I respected. And there were some great leaders there that I respected. We got a gentleman named Amit Malik, who's actually now still a biopharmaceutical CEO. He told me, look, you should come. And I think you can learn a lot and have a huge impact. And so I trusted him. Right. And I think a lot of these look in life. You also trust the people that you who believe in you. And that can open up a lot of doors. And that actually ended up being quite a decision to take. Though at the time, again, seemed like a very strange decision to take.

14:20Vas Narasimhan:A whole series of roles between 2005 and late 2017, early 2018, when you became the CEO. Tell me about some of the great decisions you made in that period. And tell me some about some of the howlers, where I presume you learned also a lot.

14:35Steve Sedgwick:So the big one was at 2006, after two years at Novartis Pharmaceuticals in the main ship, Basel, Switzerland, I went to the newly acquired vaccines division, which was losing money, had a very small piece of Novartis, 2 % of Novartis' sales. And at the time, it seemed like a very strange decision. Again, so I have a series of strange decisions, always following, trying to follow mission, learning, purpose. That ended up being one of the great decisions. Because what happened is when you go to a small unit and you get huge responsibility, your learning curve goes up through the roof. So I was suddenly overseeing clinical programs and development programs in our world, important things to know.

15:15Steve Sedgwick:all the way through to marketing launch programs. I had to solve all kinds of issues. And it was fully immersive. You know, I ended up being seven years, I was there eight years, I was in that division. And it was actually incredible. Before I knew it, I was running a unit. And I was testifying in front of Congress about the H1N1 pandemic. And I wasn't even 32 years old at that point in time. So I think, I think that was one of those decisions where at the time, to most people seemed like a really bad decision that in retrospect, I mean, for my growth, it was incredible. Really, really. And that's incredible for me.

15:50Vas Narasimhan:I've just learned something again from this and the fact that I've had so many conversations with you about and the rest of the industry about biotech. Why do you need them when you've got the big pharma? And you just answered the question. It's the autonomy and the speed of action and what you can do and what you can learn and the responsibility that you as an individual in a smaller group get.

16:09Steve Sedgwick:Absolutely. And you can make some big wins because you can take the risks because the downside is not as – look, Novartis has to manage a huge risk profile. I mean we're a 270 billion market cap company. When you're a small unit just trying to experiment, you just have to figure it out. Sometimes you'll win. Sometimes you won't. And that's okay. So I think that was a really, really interesting decision. The other one I'll tell is – I don't know. It's always hard in Buddhism to say who is to say what is good or not good. because often things that seem good at the time end up being bad. Sometimes the thing bad at the time end up being good, but it's all just the cycle of how these things work.

16:45Steve Sedgwick:I remember in 2014, Novartis actually sold the vaccines division to GlaxoSmithKline. And at the time, I wasn't exactly sure. If you can imagine that less than four years from there, I would become CEO of the company. I did not have a next role at Novartis. And I wasn't exactly sure would I go with the acquisition to GSK or would I find a role. And then I got a call from our CEO at the time and said, we're going to send you to the generics division, Sandoz, in Germany. And immersed myself in it. And then five months later, I got another call and I was the head of drug development at Novartis Pharmaceuticals.

17:21Steve Sedgwick:And three years later, I'm the CEO of the company. So these are really hard to predict how these things unfold.

17:26Vas Narasimhan:I would imagine as part of you may have thought, I really like this autonomy. I like the scale of the company. I'm going to stay with either this vaccine company with Glaxo or actually go elsewhere and become a vaccines CEO or a biotech CEO.

17:39Steve Sedgwick:I think it's easy to get too fixed kind of in your career as well. And I think to be open to possibilities that a decision in one direction could open three other decision doors in another direction.

17:50Vas Narasimhan:Tell me about something you got really badly wrong early in your career. Everyone I know has. And everyone I've interviewed pretty much. I thought this was going to be the moment where I'm booted out the door kind of thing. Did you have one or two moments where obviously you learned from it, but you had a really hard time at the time?

18:05Steve Sedgwick:Well, I think certainly when I coming back, I mean, there are many of these moments, as you can imagine. But, you know, I think one that comes to mind in that early part of the career is, you know, as a very ambitious leader of Novartis Vaccines North America, I convinced the U.S. government to actually have us become the number one supplier during the swine flu pandemic. And we were the number one supplier. We won the contracts. And then that summer, we weren't able to deliver initially. And I still remember the meetings with our then CEOs and chairmen and that I had put the whole company's reputation at risk by ambitiously signing up for these deals and then not being able to deliver and then being hauled in front of Congress as well to testify about it and being called by the chief of staff of the White House.

18:52Steve Sedgwick:And, oh, that was a tough summer. own but here's the interesting thing i mean what i also learned in that experience is to go to manufacturing sites and really try to talk to people in town halls and say we can do this i know we're behind we can get there we can get there and we did get there we did deliver it so you motivated people to learn how to motivate people when with a gun to your head of course and and we figured it out how was it mentally for you at the time i i these failures these failures these setbacks.

19:22Vas Narasimhan:At the time, I had one CEO saying, I was in a fetal position, I was so upset. I had another one saying, I was making really bad decisions. I had high levels of cortisol. My mind was, I couldn't sleep. I hear a lot. What about you?

19:37Steve Sedgwick:I think earlier, I mean, now I'm more zen about these things, having gone through the ringer many times. But then? But then, yeah, tough to sleep. It's completely normal. I can tell you as a physician, I mean, these are the fight and flight responses used to be we were chased by animals when we were evolving as an ape species now it's the email you get saying what the hell did you just do right and and uh welcome to my life at cnbc more like what did you just say and yeah and then of course you have the cortisol going you don't sleep you you you're under huge stress and of course the hardest part is how do you insulate your organization from that so i found over the years it was so important that you absorb it and then that's very heavy light on you.

20:17Steve Sedgwick:But if you let it pass through you into the organization, then the organization just simply cannot perform. You have to be an absorptive buffer. And that's hard. And that's really hard on all leaders. So I think that's something we all have to contend with.

20:31Vas Narasimhan:Let's spin forward to the succession process from Joe Jimenez. 2017, tell me how it worked and about the decision you made to accept that role, because you've already said on this podcast as well,

20:44Steve Sedgwick:you never expected to be the CEO. I think that was the moment when I actually just sat down and I said, I'm going to write down what I believe this company should become on a single sheet of paper. And I think I still keep that sheet of paper. And it was very much around the cultural transformation, inspired, curious, non-bossed, not quite those words yet, but that Dan Pink concepts I wanted to bring in that I truly believe that we should be a pure play, innovative medicine company and that we should bet on technology, innovation. I called it data and digital. I didn't know about AI. So I wrote, go big on data and digital.

21:17Steve Sedgwick:That became kind of the manifesto. Now it took like much longer than I ever expected to do all of those things. But yeah, that was it. And then I went through the process. And I remember still, it was a board meeting. I got called in by the chairman. He told me I'm going to become the next CEO. And I was really incredibly excited. I ran upstairs to call my wife, Shristi. And she said, look, I'm in a meeting. Could I call you back later? And she just quickly hung up. So I was like, okay, I'm not allowed to tell anybody. And then the funniest thing, I was actually had to go to fly to another meeting.

21:51Steve Sedgwick:And I was actually on a Ryanair flight. We were in Dublin where this board meeting is. And then I was like delayed in the Ryanair and Dublin airport for like 12 hours. I was like, here it is. I've been named CEO of this giant company. And the reason I keep coming back to that is how do you stay humble and grounded throughout the whole thing, right? and I think it's so important. Well, I think you stay humble and grounded by traveling on Ryanair.

22:16Vas Narasimhan:All due respect to the great Michael O 'Leary. That's as humbling as it gets.

22:20Steve Sedgwick:Yeah, yeah, a good reminder.

22:21Vas Narasimhan:That's hero to zero stuff as well.

22:28Vas Narasimhan:The first year of CEO was rough. You walked straight into a crisis. For our viewers and listeners, three months into the post, you had to apologize to employees and indeed you were hauled over the cold, publicly with a lot of truths and a lot of untruths as well about the fact that your company had hired Michael Cohen's consulting company in February 2017, which is way before you became CEO, a 1.2 million year long contract as well. That was perhaps in retrospect, I think very clearly, not the right thing for Novartis to do, but you had to bear the brunt straight away.

23:03Steve Sedgwick:Yeah, I think that first six months, we had the Michael Cohen situation. We also had a very large Greece investigation from the SEC DOJ. We had another investigation into practices in Asia and talk about getting thrown into the maelstrom. And, you know, I think it's easy to coach new CEOs about these things. But when you go through it, it's the first time it's your name. And seeing all of that, it's jarring, right?

23:28Vas Narasimhan:I remember talking to you about it. And I'll put my hands up here. You stood up, you took the questions, you know, this wasn't your message, but you'd inherited it as a senior member of the team that had hired Michael Cohen and now the CEO as well. Yeah. Unbelievably tough.

23:43Steve Sedgwick:Very, very tough. I also say, I mean, I made some missteps throughout that whole process. What mistakes did you make? Look, I think I should have owned it on behalf of the company. My first response is, I think I even said on maybe it was on CNBC, look, this didn't happen under my watch. That doesn't matter. Right now, I'm the steward of the company. I need to own it. And I think in retrospect, I should have just said, doesn't matter. our company shouldn't have done this, you know, and we need to own it, and then step forward. So I think I learned a lot in that whole process that first six months, because then it came straight to the Greece, the Alcon investigation in Asia.

24:17Steve Sedgwick:And then 2019, the FDA investigation

24:20Vas Narasimhan:to manipulated data on a gene therapy as well. I mean, you are you are firefighting from day one for a good 18 months.

24:28Steve Sedgwick:Yeah, it was it was 18 months of trial by fire. It builds a thick skin, that's for sure you need that in this job but it's hard to build a thick skin without taking some of the did you question then at any moment your decision to become cea no i think i was i was at that point i'm kind of the you know another thing my parents instilled in me is you stay in the ring and because the in the end just staying in the ring is hard enough right yeah and if you can stay in the ring stay resilient that you can overcome if you just keep getting back up you're

24:59Vas Narasimhan:getting a lot of brickbats thrown at you from people who have never been in the ring. Absolutely. And if they haven't been in the ring, and I feel like this on CNBC, I don't want to, I didn't care what they say. If they've never been in the position, they don't understand what it's like.

25:10Steve Sedgwick:They don't understand what it's like. But you know, I think in, I have a much more mature perspective then. But I mean, back then I was very angry at the journalist community. I was like, why are they bashing me? And it was tough.

25:21Vas Narasimhan:You didn't show it to me, which I'll take on board. Look, another really, really, really tough decision amidst the pandemic, eliminating 10 ,000 jobs. That is without doubt the toughest decision of your career, isn't it?

25:33Steve Sedgwick:For sure. I mean, and these are all things I kind of always knew that we needed to do and that I struggled with, I think, because it was the pandemic. There was always a reason not to do it. A company I had grown up at, a company where I knew so many people around the world. and then to take out over 10 % of our workforce, many people I knew was really, I think, a tough decision.

25:55Vas Narasimhan:Funnily enough, again, I spoke to the CEO about a very similar decision that he had to make when he became CEO, same kind of numbers, huge, 10 ,000 plus people as well. He said, as long as you do it with respect and you're respectful to the employees which you're letting go of and the employees are still there and you explain to them exactly why you're doing this, then then you it's a much easier process i think to a person that i would interact with they all

26:21Steve Sedgwick:understood because we really took the time to explain why like why strategically this makes sense why we need to focus as a pure play why we need to simplify why we need to stream down line down the pipeline and spending that extra time saying why i think people understood no there's still the personal impact of individuals leaving and you know basel is a small place so everybody knows everybody. So you know, a lot of people, my kids, friends, parents, and so it was a tough time. It turned out, as you've seen the performance, it was the right move. But that's not a given. And I think, yeah, it was a tough couple of years.

26:56Vas Narasimhan:I would imagine in your position, there is nothing more exciting, nothing that validates the decisions you've made. When you get drugs through, drugs that change people's lives. I want to know about that feeling when you've backed a drug, it works. It's got past stage three and you know this is going to make a big difference.

27:15Steve Sedgwick:I cry every time we have a phase three win. It doesn't surprise me. Because I mean, many of these projects I've been with since 2013, 2014, or I started them or I know the teams and most of them sadly don't work, right? And when you have one that really changes in the case of Kiskali, the whole shape of breast cancer therapy or Pluvicta, prostate cancer, Assemblix, You know, again, cancer, chronic myelogenous leukemia. I mean, it's an extraordinary moment. And it's not just those. I mean, one of my favorite ones happened last November. We discovered and successfully developed the first new malaria drug coming back to my time in Africa in 25 years.

27:53Steve Sedgwick:And so for me, flashing back to sitting in a hospital in Tanzania and watching children die of malaria, knowing my company has provided Coartem to 1.2 billion people, and then making that next discovery, of course you cry. because you put your whole heart and soul into this work. That's the only way you can do it.

28:08Vas Narasimhan:We've covered a lot of ground about your personal ethos in making decisions. Just tell me how you want to put into words your ethos and your values when you make decisions.

28:16Steve Sedgwick:There's so many things we can be doing with our energy and our time. But one thing I've learned through this transformation process is we have to stay focused on what we're great at, discovering, developing the most cutting edge medicines. Just to give you an example, people always say, why don't you get into devices? Why don't you get into diagnostics? Why don't you buy an AI company? And, you know, I think we have to stay on mission. That's the first step. Second, is it consistent with our responsibility to the stakeholders that we have? So people often ask me, why do you still guys do malaria and leprosy and neglected tropical diseases?

28:47Steve Sedgwick:Well, that's aligned with our mission. And we've made a commitment to global health for 100 years as a company. We've been the leader in global health and engaging in medicine in Africa. So we have to keep our commitments to those stakeholders. And then, of course, can you execute? I mean, in the end, there are sometimes things that are both of the first two things, but we're not the right company to do it. And those are tough decisions, right? You can find, I'll give you an example, a rare cancer medicine that aligned with our mission, consistent with our goal to deliver medicines to cancer patients, but too small to move the needle for a$60 billion revenue company.

29:25Steve Sedgwick:And then we have to say no. And that's hard to tell those scientists. Look, there's a biotech who's better served to do this. but those are also the tough choices we have to make i want to talk about you personally and

29:34Vas Narasimhan:decisions you make in your life i look at myself and i'm actually going to compare myself to you now i'm like a poor man's vasnera semen i i monitor my blood sugar i try and sort my sleep out i concern about my mental health my physical health i work on all of these and i work on my sleep i've got a sneaky feeling you work on all of those a little bit better than i do because i know that they're actually part of how you try and conduct your personal life as well well so first

29:58Steve Sedgwick:I'm not, don't believe that's true, Steve, you're looking great. But, but I would just cut that. But look, I would say, you know, I am, I do believe and it's been consistent. And I had, you know, a great friend and coach Scott Pelton, who's helped me with this now for 15 years, mindset, movement, nutrition and recovery. Mindset, can you put yourself in the right mindset every day to have high impact? Think about your high impact moments, realize you're not your thoughts and emotions, and you have to be able to observe your thoughts and emotions to be able to navigate the craziness of what we have to deal with.

30:29Steve Sedgwick:Movement, I think any form of movement, but being more consistent, whatever it is, and I'm a big exerciser, but being consistent has huge, huge benefit. Nutrition, I always say, why do you eat? So sometimes I eat for performance, sometimes I eat for pleasure, but I don't just eat to eat. And that's very easy in today's world, where you're surrounded by food everywhere. So purposeful eating, and then of course, recovery. And now my biggest obsession now is sleep with all kinds of approaches to try to figure out how to sleep better because I think sleep is the ultimate medicine in the end. But I think the biggest thing on all four of those is whatever you choose to do, just pick things and do them consistently.

31:09Steve Sedgwick:The hardest thing is to do these things consistently because the benefits just accrue and compound. And people ask me, like, how do you put up with the travel? It's because I do those things every single day in some form. And then over years, is the benefits compound.

31:23Vas Narasimhan:I'll bear that in mind. It's my consistency. And I will go for that run again tomorrow. Final, final question. What are the big decisions for you personally going forward?

31:33Steve Sedgwick:First and foremost is helping my sons navigate their transition into college. And really, with my wife taking on her leadership role, I've had to learn how to become more of a lead parent. So that's really on my mind. I mean, I want to make sure they have the next step sorted out. And then of course, at some point, what's next for me? And I think one of the hardest things as a CEOs, you can only go into this 200%, 300%. I have no idea when the moment will come. But when the moment comes, like, yeah, now what? I mean, I've had the greatest job I could have ever imagined in my life, had unbelievable impact on the world, on Africa, on the planet, on medicine.

32:07Steve Sedgwick:So that's kind of a daunting challenge, I have to say. And I don't have any insight. Maybe I'll come back to you, Steve, for some advice. Since you seem to know me really well, you can counsel me on whatever that is.

32:17Vas Narasimhan:I don't know if I know you really well, but I've learned a lot about you for this podcast. And I've Love the journey as well. So thank you so much indeed for your time, Baz Narasim.

32:24Steve Sedgwick:Appreciate it.

32:25Vas Narasimhan:That was a great conversation with Baz Narasim, both personally and professionally. He's just so interesting. He's always wanted to make an impact. He's got such great role models from his education, but especially from his family. His hardworking immigrant parents really instilled the desire to make an impact, but strong ethics within him as well. 20-year-plus career at Novartis. He's always wanted to progress humanity, to get these drug breakthroughs, which he said himself, they make him cry when he has them because he knows they're going to make a positive impact in people's lives. Personally, I want to be Vas Narasim and he concentrates on his sleep, his health, his mental health, his physical well-being, his nutrition.

33:10Vas Narasimhan:He's kind of a role model for a lot of us as well. A really fascinating guy. Thank you very much indeed for joining me on executive decisions. I would love to hear your feedback. Drop your thoughts in the comments or a review and please hit that follow or subscribe button.

From the publisher

Guided by immigrant roots, public‑health purpose and a belief in “staying in the ring,” Novartis CEO Vas Narasimhan reflects on the unlikely decisions that took him from the “steel town” of Pittsburgh, Pennsylvania to the helm of a global drugmaker.

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