The Generalist cover art
Podcast · 50 episodes

The Generalist

by Mario Gabriele · English

“The future is already here. It’s just not evenly distributed.” The Generalist Podcast brings you weekly conversations with the people who live in these pockets of the future – visionary founders, prescient investors, and original thinkers. Each episode is designed to introduce you to new ideas, technologies, and markets and help you prepare for the world of tomorrow.

Latest episodes

All episodes

Periodic Labs: A chatbot walks into a laboratoryPeriodic Labs aims to build “synthesis superintelligence”: an AI scientist that can intentionally synthesize matter by running an end-to-end loop of simulation, experiment, and learning from…29 Sep 2026 · 1 h · 31 chapters
An Ex-SpaceX Engineer on Elon Musk, Starship, and Building a $1B-Valued Startup (Scott Morton, Founder & CEO of Revel)Scott Morton, an ex-SpaceX engineer and founder of Revel, explains why industrial “control software” hasn’t improved since the 1980s/90s, how AI helps but doesn’t replace the need for specialized,…8 Sep 2026 · 57 min · 34 chapters
38x in Ten Months: Inside One of Fintech’s Fastest-Growing Infrastructure Companies (Farooq Malik, CEO of Rain)Rain’s stablecoin-based infrastructure for global financial products—why stablecoins “behave like cash,” how they reduce hidden friction and deadweight cost in money movement, and what this could…18 Aug 2026 · 1 h 15 min · 31 chapters
AI Got Good at Language. Now It’s Learning the Language of Life. (Eric Nguyen, Co-Founder and CEO of Radical Numerics)Radical Numerics teaches AI to read, write, and program biological function in DNA, arguing DNA is biology’s “language” and that multi-omics integration is the next frontier.4 Aug 2026 · 1 h 22 min · 31 chapters
The Token Budget Problem Nobody Is Talking About (Matan Grinberg, Co-Founder & CEO of Factory)The “token budget problem” in enterprise AI—how companies will need to allocate limited inference tokens across teams and workflows, and why software engineering should shift from writing code to…30 Jun 2026 · 1 h 17 min · 32 chapters
Own or Be Owned: Why Every Company Needs Its Own AI Model (Yash Patil, Co-Founder & CEO of Applied Compute)The episode argues that companies should “own their intelligence” by training and serving custom AI models on their own data, rather than relying on frontier closed models that may restrict…23 Jun 2026 · 1 h 8 min · 25 chapters
What America Is Missing Between Sanctions and Nuclear War (Bryon Hargis, Co-Founder & CEO of Castelion)The episode argues the U.S. is losing “credible middle” deterrence options between economic sanctions and nuclear war.2 Jun 2026 · 1 h 16 min · 18 chapters
“Our Goal Is to Build an Electrical Engineer.” (Davide Asnaghi, Co-Founder & CEO of Diode)Diode (Brooklyn) is building an “AWS for electronics” by using AI to design and manufacture printed circuit boards (PCBs) in the United States, aiming to speed hardware iteration like software.19 May 2026 · 1 h 12 min · 36 chapters
Investing Like A Mystic: How Cyan Banister Finds Outliers (Co-Founder of Long Journey Ventures)Cyan Banister (Long Journey Ventures) explains “investing like a mystic”: using unusual sensory/behavioral observation to find outliers, then validating ideas through experiments.5 May 2026 · 1 h 13 min · 33 chapters
The Future Of Drug Discovery Is 4 Billion Years Old (Viswa Colluru, Founder & CEO at Enveda)Drug discovery fails when lab-active compounds don’t work in people; Enveda (founded by Viswa Colluru) argues the solution is to re-center chemistry and natural products, using AI to search nature’s…21 Apr 2026 · 1 h 23 min · 34 chapters
How a 20-Person Startup Won Gold at the Math Olympiad—Tying With OpenAI & DeepMind (Tudor Achim, CEO of Harmonic)Tudor Achim (Harmonic CEO) argues that trustworthy AI for math requires formal verification, not just plausible text.14 Apr 2026 · 1 h 5 min · 34 chapters
30% Of Network Engineers Are Retiring. What Happens Next? (Anil Varanasi, Co-Founder & CEO of Meter)Meter’s approach to “autonomous networks” amid a looming shortage: ~30% of network engineers are retiring by the end of the decade without replacement.7 Apr 2026 · 1 h 11 min · 38 chapters
Why One Superintelligence Is More Dangerous Than a Thousand (Vincent Weisser, CEO & Co-Founder of Prime Intellect)In this episode of The Generalist, host Mario interviews Vincent Weisser, the CEO & Co-Founder of Prime Intellect.24 Mar 2026 · 1 h 19 min · 41 chapters
Why Robots Still Struggle With Simple Tasks (And What Might Finally Change That) | Karol Hausman, Co-Founder & CEO of Physical IntelligenceWhy Robots Still Struggle With Simple Tasks (And What Might Finally Change That)17 Mar 2026 · 1 h 14 min · 31 chapters
America’s Electric Power Grid Is Broken. This Startup Is Trying to Fix It. (Zach Dell, co-founder & CEO of Base)Zach Dell, co-founder & CEO of Base10 Mar 2026 · 1 h 12 min · 29 chapters
Everyone Is Betting on Bigger LLMs. She's Betting They're Fundamentally Wrong. (Eve Bodnia, Founder & CEO of Logical Intelligence)Everyone Is Betting on Bigger LLMs. She's Betting They're Fundamentally Wrong.24 Feb 2026 · 1 h 8 min · 23 chapters
How Bolt Survived An 85% Revenue Crash And Became Europe's Ride-Hailing Champion (Markus Villig, Founder & CEO)How Bolt Survived An 85% Revenue Crash And Became Europe's Ride-Hailing Champion19 Feb 2026 · 1 h 20 min · 49 chapters
The Private Company Bringing Nuclear Enrichment Back to America (Scott Nolan, CEO of General Matter)The Private Company Bringing Nuclear Enrichment Back to America3 Feb 2026 · 1 h 16 min · 28 chapters
Programming Sunlight: How Reflect Orbital Is Building Satellites to Redirect Light From Space (Ben Nowack, Founder & CEO)Ben Nowack, Founder & CEO of Reflect Orbital20 Jan 2026 · 1 h 19 min · 26 chapters
Nothing’s Carl Pei on Building a $1B Smartphone Company, Why He Left OnePlus After 10 Days of Retirement, and Why He Thinks About Death Every WeekNothing’s Carl Pei on Building a $1B Smartphone Company, Why He Left OnePlus After 10 Days of Retirement, and Why He Thinks About Death Every Week13 Jan 2026 · 1 h 19 min · 43 chapters
Why Being a Generalist VC Is a Competitive Advantage (Aydin Senkut, Founder & Managing Partner at Felicis Ventures)Why Being a Generalist VC Is a Competitive Advantage9 Dec 2025 · 1 h 17 min
Joey Krug on Prediction Markets, Crypto Treasuries & the Next Era of On-Chain Finance (Partner at Founders Fund)In this episode, host Mario interviews Joey Krug, co-founder of Augur and partner at Founders Fund, exploring the evolution and significance of prediction markets, the emergence of crypto treasury…2 Dec 2025 · 1 h 16 min
How a Solo Founder is Reshaping Global Finance (Parth Garg, CEO of Aspora)In this episode, Parth Garg shares his journey from a physics prodigy to a successful fintech founder after his co-founder abruptly left the company.18 Nov 2025 · 1 h 9 min
How Do You Build a New Singapore? Inside Próspera’s Bet on Private Governance (Erick Brimen, Founder & CEO)How Do You Build a New Singapore? Inside Próspera’s Bet on Private Governance (Erick Brimen, Founder & CEO)11 Nov 2025 · 1 h 24 min